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    MOSQUITO EGG CRYOPRESERVATION
    1.
    发明申请
    MOSQUITO EGG CRYOPRESERVATION 有权

    公开(公告)号：US20220248663A1

    公开(公告)日：2022-08-11

    申请号：US17626381

    申请日：2020-07-13

    申请人： Sanaria Inc.

    发明人： Eric R. JAMES

    IPC分类号： A01N1/02 ,  A01K67/033

    摘要： Herein is described a method devised to cryopreserve mosquito eggs, viable upon subsequent thawing. The method reproducibly yields >25% hatched first instar larvae of Anopheles-species mosquitoes from cryopreserved eggs. The majority of hatched larvae continue to develop normally (87% pupation), through to adults (98%, 50% of which are female) which subsequently blood feed and produce viable second generation embryos that also develop normally. Adult mosquitoes obtained from cryopreserved embryos are able to be infected with Plasmodium falciparum gametocytes and produce salivary gland sporozoites in similar numbers to control mosquitoes.

    Infectious plasmodium sporozoites grown in vitro
    2.
    发明授权
    Infectious plasmodium sporozoites grown in vitro 有权

    公开(公告)号：US10441646B2

    公开(公告)日：2019-10-15

    申请号：US15858574

    申请日：2017-12-29

    申请人： SANARIA INC.

    发明人： Abraham G. Eappen ,  Stephen L. Hoffman

    IPC分类号： A61K39/015 ,  A61K39/00 ,  A61K49/00 ,  C12N1/10

    摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.

    INFECTIOUS PLASMODIUM SPOROZOITES GROWN IN VITRO
    8.
    发明申请
    INFECTIOUS PLASMODIUM SPOROZOITES GROWN IN VITRO 有权
    感染性体外培养的体外培养物

    公开(公告)号：US20160287688A1

    公开(公告)日：2016-10-06

    申请号：US15095360

    申请日：2016-04-11

    申请人： SANARIA INC.

    发明人： Abraham G. EAPPEN ,  Stephen L. HOFFMAN

    IPC分类号： A61K39/015 ,  C12N1/10

    CPC分类号： A61K39/015 ,  A61K2039/52 ,  A61K2039/522 ,  C12N1/10 ,  Y02A50/412

    摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.

    摘要翻译： 该应用涉及人宿主范围的体外培养的疟原虫子孢子，其中从配子细胞阶段到子孢子期的孢子体在蚊子外部，以及其生产方法。 本文提供的是人宿主范围的体外培养的感染性疟原虫子孢子（SPZ），特别是恶性疟原虫，间日疟原虫，卵白念珠菌，疟原虫和know know属，其中从配子细胞阶段到子孢子期的孢子是外部的 蚊子，以及生产蚊子的方法。