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公开(公告)号：US20230134571A1
公开(公告)日：2023-05-04
申请号：US17772561
申请日：2020-10-29
发明人： Devin SOK , Dennis R. BURTON , Joseph G. JARDINE
摘要： The present disclosure relates to anti-HIV Env antibodies and their use in the treatment or prevention of HIV/AIDS. In one aspect, provided herein are enhanced engineered anti-HIV Env antibodies that were derived from the PGDM1400 parent antibody using directed-evolution and yeast display. In one aspect, provided herein are pharmaceutical compositions comprising the enhanced engineered anti-HIV Env antibodies disclosed herein.
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公开(公告)号：US20230116380A1
公开(公告)日：2023-04-13
申请号：US17799246
申请日：2021-02-11
发明人： Sean JOSEPH , Lei LEI , Weijun SHEN , Feng WANG , Peter SCHULTZ
IPC分类号： C07K14/535 , C07K16/10 , A61P25/28
摘要： Disclosed herein are granulocyte-macrophage colony-stimulating factor (GM-CSF) peptides and compositions comprising GM-CSF peptides. These molecules may be useful for the treatment of neurological diseases or conditions.
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公开(公告)号：US20230060376A1
公开(公告)日：2023-03-02
申请号：US16642810
申请日：2018-08-03
摘要： Methods and systems are described herein for generating engineered B cells with modified immunoglobulin genes. The modified immunoglobulin genes encode modified immunoglobulins that can have high affinity for antigens, including antigens that are variable such the types of antigens on various pathogens that can escape mammalian immune responses.
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公开(公告)号：US20230046065A1
公开(公告)日：2023-02-16
申请号：US17778069
申请日：2020-11-24
发明人： Jin-Quan YU
摘要： Palladium-catalyzed C(sp3)—H arylation of aliphatic carboxylic acids, amides and ketones with BNA-encoded aryl iodides in water is disclosed, Furthermore, sequential C—H arylation chemistry enabled the on-DNA synthesis of structurally-diverse scaffolds containing enriched C(sp3) character, chiral centers, cyclopropane, cyclobutane, and heterocycles. That new chemistry permits preparation of a DNA—encoded library (BEL) technology that can dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment. The sequential functionalization of multiple C—H bonds provides an unique avenue for creating diversity and complexity from simple starting materials. The use of water as solvent, the presence of DMA, and the extremely low concentration of DMA-encoded coupling partners (0.001 M) have previously hampered the development DMA-encoded C(sp3)—H activation reactions, but many of those hurdles have now been overcome.
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公开(公告)号：US20230037822A1
公开(公告)日：2023-02-09
申请号：US17755382
申请日：2020-10-28
发明人： James C. Paulson , Maidul Islam , Fabian Pfrengle , Matthew Macauley , Shiteng Duan , Britni Arlian
摘要： Described herein are Siglec ligand-antibody conjugates and compositions thereof that are useful for suppressing unwanted immune responses such as allergies and anaphylaxis.
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公开(公告)号：US20230034467A1
公开(公告)日：2023-02-02
申请号：US17554907
申请日：2021-12-17
发明人： Linling He , Jiang Zhu , Erick Giang , Mansun Law , Ian Wilson , Netanel Tzarum
IPC分类号： C07K14/005 , C12N7/00 , A61K39/29 , A61P31/14 , A61K47/69
摘要： The present invention provides novel engineered HCV E2 polypeptide immunogens and related vaccine compositions that display the engineered E2 polypeptides. The invention also provides methods of using such immunogens and vaccine compositions in various therapeutic applications, e.g., for preventing or treating HCV infections.
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公开(公告)号：US20230033285A1
公开(公告)日：2023-02-02
申请号：US17842415
申请日：2022-06-16
发明人： Arnab K. Chatterjee , Jian Jeffrey Chen , Elshan Nakath , Alireza Rahimi , Anil Kumar Gupta , Gennadii Grabovyi , Katy Wilson , Sourav Ghorai , Armen Nazarian , James Pedroarena , Wrickban Mazumdar , Frank Weiss , Lirui Song , Malina A. Bakowski , Laura Riva , Karen Wolff , Case W. McNamara , Thomas F. Rogers , Jacqueline Malvin , Shuangwei Li , Sean Joseph , Ashley Woods , Yuyin Liu , Neechi Okwor
IPC分类号： C07D491/048 , C07D403/12 , C07D207/26 , C07D401/12 , C07D211/76 , C07D223/10 , C07D405/14 , C07D413/14 , C07D401/14 , C07D413/12 , A61P31/14
摘要： Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.
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8.发明申请公开(公告)号：US20230002329A1
公开(公告)日：2023-01-05
申请号：US17755105
申请日：2020-10-29
IPC分类号： C07D235/18 , C07D333/36 , C07K7/06 , A61P35/00 , C07D409/14 , C07D403/14
摘要： Small molecule compounds and corresponding dimers having inhibitory activity against pre-miR-21 RNA and related methods for treatment of neoplastic disease such as cancer and especially cancers expressing miR-21 are disclosed.
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公开(公告)号：US20220332751A1
公开(公告)日：2022-10-20
申请号：US17642559
申请日：2020-09-11
IPC分类号： C07H19/16 , A61K9/10 , A61K47/38 , A61K31/4985 , A61K31/5365 , A61K31/4439 , A61K31/675 , A61K31/513 , A61K47/26 , A61P31/18
摘要： Diesters of 4′-ethynyl-2-fluoro-2′-deoxyadenosine and aqueous parenteral suspensions thereof provide extended in vivo viral suppression of human immunodeficiency virus (HIV).
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公开(公告)号：US20220313780A1
公开(公告)日：2022-10-06
申请号：US17617989
申请日：2020-06-17
摘要： The present invention provides novel compositions for suppressing inflammation and for treating inflammatory disorders. These compositions contain at least one PARS-derived anti-inflammatory peptide or polypeptide and/or at least one PARI-derived anti-inflammatory peptide or polypeptide. The PARS- and/or PARI-derived peptides typically contain an amino acid sequence that mimics the respective N-terminal sequence of Activated Protein C-cleaved PARS or PARI, e.g., after activated protein C cleavage at residue Arg41 in human PARS and after residue Arg46 in human PARI. The invention also provides therapeutic methods of using the anti-inflammatory compositions described herein to suppress undesired inflammation and to treat inflammatory disorders. Additionally provided in the invention are methods of screening candidate compounds to identity novel anti-inflammatory agents.
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