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公开(公告)号：US20170071210A1
公开(公告)日：2017-03-16
申请号：US15123549
申请日：2015-02-20
发明人： Peng Zhang , Bo Hu , Hong Tang
CPC分类号： A01N59/16 , A01N25/26 , A61K41/0057 , A61K47/6923 , A01N25/00
摘要： The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16). A method of killing bacteria may include contacting bacteria with a nanostructure (10) including a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16) to form a blend and exposing the blend to light.
摘要翻译： 本发明一般涉及使用与光敏剂偶联的表面等离子体激活杀死细菌的组合物和方法。 纳米结构（10）可以包括银纳米颗粒芯（12），介孔二氧化硅壳（14）和光敏剂（16）。 杀死细菌的方法可以包括使细菌与包括银纳米颗粒核心（12），介孔二氧化硅壳（14）和光敏剂（16）的纳米结构（10）接触以形成共混物并将共混物曝光。
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公开(公告)号：US20230072303A1
公开(公告)日：2023-03-09
申请号：US17795279
申请日：2021-01-26
发明人： Jinghua Wang , Lili He
摘要： A method for spatial resolution enhanced imaging is provided. The method includes determining a target region of a subject being imaged; estimating an achievable spatial resolution; selecting an increased spatial resolution that is greater than a predetermined spatial resolution and equal to or less than the achievable spatial resolution; and acquiring image data of the target region with the increased spatial resolution. A method for enhancing the contrast between the region of interest and other tissue region in the image data acquired with the increased spatial resolution and other tissue region in image data acquired with the predetermined spatial resolution due to the intrinsic partial volume effect is also provided.
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公开(公告)号：US20230043982A1
公开(公告)日：2023-02-09
申请号：US17859040
申请日：2022-07-07
发明人： Stevan David JONES , David Frederick SWAILE , Harshita Kumari , Chandra A. ADE-BROWNE , Arnab DAWN
摘要： An aqueous antiperspirant composition comprising: 1) a metal salt with a M:X mole ratio from about 0.25 to 0.5, wherein X is an anion with a −1 or −2 charge and M is a metal ion with a +2, +3 or +4 charge; 2) an amino acid wherein the M:amino acid mole ratio is from about 5 to about 0.33; and 3) wherein the pH of the composition is from about 2 to about 4.
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公开(公告)号：US20220412914A1
公开(公告)日：2022-12-29
申请号：US17823286
申请日：2022-08-30
发明人： Joshua A. Hagen , Jason C. Heikenfeld , Ian Papautsky , Linlin Hou , Rajesh Naik , Nancy Kelley-Loughnan , Morley O. Stone , John Busbee , Xiao Wang
IPC分类号： G01N27/327 , A61B5/00 , A61B10/00 , A61B5/145 , A61B5/1477 , B01L3/00 , G01N27/414
摘要： Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.
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公开(公告)号：US11535834B2
公开(公告)日：2022-12-27
申请号：US16681078
申请日：2019-11-12
IPC分类号： C12N9/22 , C12Q1/6869 , C12Q1/6806
摘要： A recombinant ribonuclease is disclosed. The recombinant ribonuclease is produced by introducing a recombinant DNA sequence into a host; activating expression of the recombinant DNA sequence within the host to produce the recombinant ribonuclease; and isolating the recombinant ribonuclease from the host. Additionally, a method of analyzing an RNA sequence includes digesting the RNA with a first recombinant ribonuclease to give digestion products comprising nucleotides of the RNA sequence; and analyzing the digestion products using an analytical method to provide the identity of at least some of the nucleotides. The recombinant ribonuclease includes at least one of a uridine-specific recombinant RNase MC1 and a cytidine-specific recombinant RNase Cusativin.
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公开(公告)号：US20220364090A1
公开(公告)日：2022-11-17
申请号：US17746360
申请日：2022-05-17
发明人： Yigang Wang , Wei Huang
IPC分类号： C12N15/113 , A61P9/00 , C12N5/077
摘要： Inhibitors of miRNA-128 capable of promoting cardiomyocyte mitotic cell proliferation and methods effective for regeneration of heart tissue.
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公开(公告)号：US20220354787A1
公开(公告)日：2022-11-10
申请号：US17859537
申请日：2022-07-07
发明人： Vladimir Kalinichenko , Andrew Dunn , Donglu Shi
摘要： Disclosed herein are nanoparticle compositions containing that may be created by functionalizing polyethylenimine (PEI) with fatty acids and carboxylate terminated poly(ethylene glycol) (PEG). The disclosed compositions may be delivered to an individual in need thereof via delivery into blood circulation, where the nanoparticle compositions show an exceptionally high specificity to the pulmonary microvascular endothelium with minimal targeting of other cell types in the lung, to provide delivery of therapeutic agents such as stabilized nucleic acids. Methods of using the compositions are also disclosed.
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公开(公告)号：US20220339328A1
公开(公告)日：2022-10-27
申请号：US17863068
申请日：2022-07-12
发明人： Aaron Seitz , Michael Edwards , Erich Gulbins , Ryan Gobble
摘要： Methods for applying a coating to a surface of a substrate for inhibition and prevention of implant-associated complications (including implant-associated infections), methods for inhibiting and preventing implant-associated complications (including implant-associated infections), implant-associated infection inhibiting coatings, and coated devices are provided. Coating processes include a) providing a saturated or supersaturated solution of an antibiotic in a fast-evaporating or medium-evaporating organic solvent; b) coating the surface of the substrate with at least one application of solution, each application followed directly by a solvent evaporation period.
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公开(公告)号：US20220296949A1
公开(公告)日：2022-09-22
申请号：US17655688
申请日：2022-03-21
发明人： Vesselin N. Shanov , Soryong Chae , Yanbo Fang , Hyunsik Kim , Yoontaek Oh , Hung Nguyen
摘要： The present invention relates to a carbon-based material for use in a piece of personal protective equipment and an air filtration system. The carbon-based material may function as a filter by providing a tortuous path for a pathogen to traverse. The carbon-based material may be used as a carbon-based heater that can reach a pathogen inactivation threshold temperature to enable heat inactivation of one or more pathogens. In embodiments where a piece of personal protective equipment includes a carbon-based heater, an insulating layer may be included to attenuate the temperature generated by the carbon-based heater from the face of a user.
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公开(公告)号：US20220290458A1
公开(公告)日：2022-09-15
申请号：US17654473
申请日：2022-03-11
摘要： A structural assembly and a structural bracing system including the structural assembly are presented. The structural assembly includes Belleville disks and shape memory alloy (SMA) rods with nonlinear elastic behavior (e.g., Nitinol rods) to resist lateral force. Stacked Belleville disks are placed between plates resulting in nonlinear elastic behavior in compression. Shape memory alloy rods are placed at the corners of the plates and held by nuts at the exterior faces of the plates. The rods are loose when a compression load is applied to the plates and will work in tension when a tensile load is applied to the plates. A shaft (e.g., steel tube) is placed at the center of the Belleville disks to stabilize the assembly. Addition of the assembly with nonlinear elastic behavior in both tension and compression loadings to a structural bracing system improves the structural behavior of the bracing system.
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