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    Compositions and methods for topical application of therapeutic agents
    1.
    发明授权
    Compositions and methods for topical application of therapeutic agents 失效

    公开(公告)号：US5863560A

    公开(公告)日：1999-01-26

    申请号：US712454

    申请日：1996-09-11

    申请人： David W. Osborne

    发明人： David W. Osborne

    IPC分类号： A61K9/06 ,  A61K45/00 ,  A61K47/30 ,  A61P23/02 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61K9/10 ,  A61K47/32 ,  A61K47/38

    CPC分类号： A61K9/06 ,  Y10S514/859 ,  Y10S514/944

    摘要： The present invention generally relates to pharmaceutical compositions that enable control of drug delivery properties and the development of optimal drug delivery strategies customized for particular drugs and particular diseases. The composition includes a dissolved pharmaceutical that has the capacity to permeate the stratum corneum layer of the epidermis and become available systemically, and a pharmaceutical in a microparticulate state that does not readily cross the stratum corneum of the epidermis. The dissolved and microparticulate pharmaceuticals may be the same or different pharmaceuticals. Methods for the preparation and use of the compositions are also provided. In a preferred embodiment, the invention finds particular use in a formulation for the topical application of dapsone for the treatment of acne. In another preferred embodiment, the invention finds particular use for the treatment of herpes lesions.

    Topical composition enhancing healing of viral lesions
    3.
    发明授权
    Topical composition enhancing healing of viral lesions 失效
    局部组合物增强病毒病变的愈合

    公开(公告)号：US5380754A

    公开(公告)日：1995-01-10

    申请号：US985279

    申请日：1992-12-04

    申请人： Bruce W. Miller ,  Richard L. Kronenthal

    发明人： Bruce W. Miller ,  Richard L. Kronenthal

    IPC分类号： A61K31/245 ,  A61K31/255 ,  A61K31/445 ,  A61K31/47 ,  A61K31/765 ,  A61K45/06 ,  A61K31/21

    CPC分类号： A61K31/765 ,  A61K31/245 ,  A61K31/255 ,  A61K31/445 ,  A61K31/47 ,  A61K45/06 ,  Y10S514/934

    摘要： Multiple daily applications of a topical composition having as the active ingredients an anesthetic and a surfactant with anti-vital activity decrease the time of healing of herpes simplex viral lesions from approximately seven to ten days to five to six days, as well as decrease inflammation and pain. The composition is applied to the lesions daily, approximately every four hours, preferably beginning at the prodromal stage of infection. Relief is almost immediate, and is characterized by decreased pain, swelling, and more rapid healing as compared with the untreated lesion.

    摘要翻译： 具有作为活性成分的麻醉剂和具有抗生物活性的表面活性剂的局部组合物的多次日常应用将单纯疱疹病毒病变愈合的时间从约7天减少至10天至5至6天，并且减少炎症和 疼痛。 每天大约每四小时将组合物施用于病变，优选从感染的前驱阶段开始。 救济几乎是立即的，其特征在于与未治疗的病变相比疼痛，肿胀和愈合愈合更快。

    Pharmaceutical preparation applicable to mucosal surfaces and body tissues
    4.
    发明授权
    Pharmaceutical preparation applicable to mucosal surfaces and body tissues 失效
    适用于粘膜表面和身体组织的药物制剂

    公开(公告)号：US5955097A

    公开(公告)日：1999-09-21

    申请号：US733454

    申请日：1996-10-18

    申请人： Gilles H. Tapolsky ,  David W. Osborne

    发明人： Gilles H. Tapolsky ,  David W. Osborne

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/38 ,  A61F13/00 ,  A61K9/14

    CPC分类号： A61K9/7015 ,  A61K9/006

    摘要： The present invention relates to a non water-soluble pharmaceutical carrier gel which adheres to mucosal surfaces and body tissues upon application and forms a film, providing protection and delivery of pharmaceutical to the site of application, surrounding body tissues, and bodily fluids. The gel comprises a volatile or diffusing nonaqueous solvent and at least one non-water-soluble alkyl cellulose or hydroxyalkyl cellulose. A bioadhesive polymer may also be added. The gel provides an effective residence time with ease of use.

    摘要翻译： 本发明涉及一种非水溶性药物载体凝胶，其在施用时粘附于粘膜表面和身体组织并形成膜，从而提供药物到施用部位，周围身体组织和体液的保护和递送。 凝胶包含挥发性或扩散性非水溶剂和至少一种非水溶性烷基纤维素或羟烷基纤维素。 还可以加入生物粘附聚合物。 凝胶提供有效的停留时间，易于使用。

    Topical composition enhancing healing of viral lesions
    6.
    发明授权
    Topical composition enhancing healing of viral lesions 失效
    局部组合物增强病毒病变的愈合

    公开(公告)号：US5696160A

    公开(公告)日：1997-12-09

    申请号：US324247

    申请日：1994-10-14

    申请人： Bruce W. Miller ,  Richard L. Kronenthal

    发明人： Bruce W. Miller ,  Richard L. Kronenthal

    IPC分类号： A61K31/245 ,  A61K31/255 ,  A61K31/445 ,  A61K31/47 ,  A61K31/765 ,  A61K45/06 ,  A61K31/21

    CPC分类号： A61K31/765 ,  A61K31/245 ,  A61K31/255 ,  A61K31/445 ,  A61K31/47 ,  A61K45/06 ,  Y10S514/934

    摘要： Multiple daily applications of a topical composition having as the active ingredients an anesthetic and a surfactant with anti-viral activity decrease the time of healing of herpes simplex viral lesions from approximately seven to ten days to five to six days, as well as decrease inflammation and pain. The composition is applied to the lesions daily, approximately every four hours, preferably beginning at the prodromal stage of infection. Relief is almost immediate, and is characterized by decreased pain, swelling, and more rapid healing as compared with the untreated lesion.

    摘要翻译： 具有作为活性成分的麻醉剂和具有抗病毒活性的表面活性剂的局部组合物的多次日常应用将将单纯疱疹病毒病变愈合的时间从约7天减少至10天至5至6天，并且减少炎症和 疼痛。 每天大约每四小时将组合物施用于病变，优选从感染的前驱阶段开始。 救济几乎是立即的，其特征在于与未治疗的病变相比疼痛，肿胀和愈合愈合更快。

    Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
    7.
    发明申请
    Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces 审中-公开
    适用于将药物化合物输送到粘膜表面的药物载体装置

    公开(公告)号：US20050048102A1

    公开(公告)日：2005-03-03

    申请号：US10962833

    申请日：2004-10-12

    申请人： Gilles Tapolsky ,  David Osborne

    发明人： Gilles Tapolsky ,  David Osborne

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K9/14

    CPC分类号： A61K9/006 ,  A61K9/7023

    摘要： The present invention relates to a pharmaceutical delivery device for application of a pharmaceutical to mucosal surfaces. The device comprises an adhesive layer and a non-adhesive backing layer, and the pharmaceutical may be provided in either or both layers. Upon application, the device adheres to the mucosal surface, providing localized drug delivery and protection to the treatment site. The kinetics of erodability are easily adjusted by varying the number of layers and/or the components.

    摘要翻译： 本发明涉及用于将药物施用于粘膜表面的药物递送装置。 该装置包括粘合剂层和非粘性背衬层，并且药物可以在两层或两层中提供。 应用后，该装置粘附于粘膜表面，为治疗部位提供局部药物输送和保护。 可以通过改变层数和/或组分来容易地调节可蚀性的动力学。

    Topical antibiotic composition providing optimal moisture environment for rapid wound healing that reduces skin contraction
    9.
    发明授权
    Topical antibiotic composition providing optimal moisture environment for rapid wound healing that reduces skin contraction 失效
    局部抗生素组合物为快速伤口愈合提供最佳的水分环境，减少皮肤收缩

    公开(公告)号：US5905092A

    公开(公告)日：1999-05-18

    申请号：US796381

    申请日：1997-02-06

    申请人： David W. Osborne ,  Meidong Yang

    发明人： David W. Osborne ,  Meidong Yang

    IPC分类号： A61K47/10 ,  A61K47/32 ,  A61K47/38

    CPC分类号： A61K47/32 ,  A61K47/10 ,  A61K47/38 ,  A61K9/0014

    摘要： A composition and method for the treatment of wounds comprising a topical semisolid composition capable of providing a moist environment for a wound and reducing skin contraction by promoting increased water content in wounds becoming dry and reduced water content in wounds having excess exudate, wherein the topical semisolid comprises water and a polyhydric alcohol having two or more gelling agents. The topical semisolid composition is used in conjunction with antibiotic formulations.

    摘要翻译： 一种用于治疗伤口的组合物和方法，其包含局部半固体组合物，其能够为伤口提供湿润环境并通过促进伤口中增加的水分含量并减少具有过量渗出物的伤口中的水分含量，其中所述局部半固体 包含水和具有两种或更多种胶凝剂的多元醇。 局部半固体组合物与抗生素制剂结合使用。

    Method and composition for cleansing wounds with minimal cytotoxicity for minimal scarring
    10.
    发明授权
    Method and composition for cleansing wounds with minimal cytotoxicity for minimal scarring 失效
    用于清洁伤口的方法和组合物，具有最小的细胞毒性以减少瘢痕形成

    公开(公告)号：US5762917A

    公开(公告)日：1998-06-09

    申请号：US624309

    申请日：1996-03-26

    申请人： David W. Osborne

    发明人： David W. Osborne

    IPC分类号： A61K31/77 ,  A61K31/765 ,  A61K7/50

    CPC分类号： A61K31/77

    摘要： A method and composition for cleansing a wound comprising irrigating the wound with a surfactant, an antiseptic, and a preservative mixed in an aqueous solution having minimal cytotoxicity, and thereby cleansing the wound with minimal scarring.

    摘要翻译： 用于清洗伤口的方法和组合物，包括用表面活性剂，防腐剂和防腐剂冲洗伤口，所述表面活性剂，防腐剂和防腐剂混合在具有最小细胞毒性的水溶液中，从而以最小的瘢痕形成来清洗伤口。