Integrated X-ray source module
    1.
    发明授权
    Integrated X-ray source module 有权
    集成X射线源模块

    公开(公告)号:US07448802B2

    公开(公告)日:2008-11-11

    申请号:US10763051

    申请日:2004-01-22

    IPC分类号: H01J35/16 H05G1/10

    CPC分类号: H05G1/06 H05G1/10

    摘要: Described is a self-contained, small, lightweight, power-efficient and radiation-shielded module that includes a miniature vacuum X-ray tube emitting X-rays of a controlled intensity and defined spectrum. Feedback control circuits are used to monitor and maintain the beam current and voltage. The X-ray tube, high-voltage power supply, and the resonant converter are encapsulated in a solid high-voltage insulating material. The module can be configured into complex geometries and can be powered by commercially available small, compact, low-voltage batteries.

    摘要翻译: 描述的是一个独立的,小型,轻便的,功率高效的辐射屏蔽模块,其中包括一个微型真空X射线管,发射受控强度和限定光谱的X射线。 反馈控制电路用于监测和维持射束电流和电压。 X射线管,高压电源和谐振转换器封装在固体高压绝缘材料中。 该模块可以配置成复杂的几何形状,并且可以由市售的小型紧凑型低压电池供电。

    Mice that make heavy chain antibodies
    2.
    发明授权
    Mice that make heavy chain antibodies 有权
    产生重链抗体的小鼠

    公开(公告)号:US08754287B2

    公开(公告)日:2014-06-17

    申请号:US12965050

    申请日:2010-12-10

    摘要: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion in an immunoglobulin constant region CH1 gene (optionally a deletion in a hinge region) of an IgG, IgA, IgD, and/or IgE, and wherein the mouse is capable of expressing a functional IgM. Genetically modified mice are described, including mice having a functional IgM gene and modified to have a deletion of a CH1 domain and a hinge region in a heavy chain constant domain that is not an IgM, e.g., in an IgG heavy chain constant domain. Genetically modified mice that make human variable/mouse constant chimeric heavy chain antibodies (antibodies that lack a light chain), fully mouse heavy chain antibodies, or fully human heavy chain antibodies are provided.

    摘要翻译: 提供了遗传修饰的非人动物以及用于制备和使用它们的方法和组合物,其中遗传修饰包括IgG,IgA,IgD和/或IgG的免疫球蛋白恒定区CH1基因(任选地在铰链区的缺失)中的缺失 /或IgE,并且其中所述小鼠能够表达功能性IgM。 描述了遗传修饰的小鼠,包括具有功能性IgM基因的小鼠,并且被修饰为具有不是IgM的重链恒定结构域中的CH1结构域和铰链区的缺失,例如在IgG重链恒定结构域中。 提供了使人可变/小鼠恒定的嵌合重链抗体(缺乏轻链的抗体),完全小鼠重链抗体或完全人重链抗体的转基因小鼠。

    Abrasion resistant composites
    3.
    发明授权
    Abrasion resistant composites 有权
    耐磨复合材料

    公开(公告)号:US07638567B2

    公开(公告)日:2009-12-29

    申请号:US12359650

    申请日:2009-01-26

    申请人: Luc-Lin Lemelin

    发明人: Luc-Lin Lemelin

    IPC分类号: B60C1/00

    摘要: In various embodiments, the present inventions provide a rubber composite having an abrasion resistance better than about 125 mm3 under DIN 53516 and comprising a natural rubber, between about 15 to about 25 parts per hundred rubber (PHR) of a butadiene, between about 20 to about 40 PHR of a silica; and between about 0.4 to about 4 PHR of an organosilane polysulfur cross-linking agent. Also provided in various embodiments are multiply rubber materials having a first ply of the above composite and a second thinner ply of a styrene-butadiene rubber.

    摘要翻译: 在各种实施方案中,本发明提供了一种橡胶复合材料,其在DIN 53516下具有优于大约125mm 3的耐磨性,并且包含天然橡胶,每百份橡胶约25至约25份(PHR)为约20至约25份 约40PHR的二氧化硅; 和约0.4至约4个PHR的有机硅烷多硫交联剂。 在各种实施方案中还提供了具有上述复合材料的第一层的多橡胶材料和苯乙烯 - 丁二烯橡胶的第二较薄的层。

    Cross-reactive sensors
    5.
    发明授权
    Cross-reactive sensors 有权
    交叉反应传感器

    公开(公告)号:US07250267B2

    公开(公告)日:2007-07-31

    申请号:US10221815

    申请日:2001-03-14

    CPC分类号: C12Q1/44 C12Q1/37

    摘要: The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements reacts in a different manner with each of said one or more species of liquid analytes of interest to produce a detectable agent of each analyte of interest, whereby said detectable agent is analyzed and the information is processed for data acquisition and interpretation. In certain preferred embodiments, the detectable agent and/or change is detected directly, while in certain other preferred embodiments, the detectable agent and/or change is detected with the help of a transducing agent capable of relaying information about each detectable agent generated for each of said species of liquid analyte of interest, whereby said information is processed for data acquisition and interpretation. The present invention also provides method for the analysis of analytes comprising contacting one or more analytes with the inventive system described above.

    摘要翻译: 本发明提供了一种利用交叉反应识别元件的新型交叉反应传感器系统。 在本发明的系统中,所述一个或多个交叉反应性识别元件中的每一个能够与多于一种的感兴趣的液体分析物相互作用,由此所述一个或多个交叉反应性识别元件中的每一个以不同的方式与每个 的所述一种或多种感兴趣的液体分析物种类以产生感兴趣的每种分析物的可检测试剂,由此分析所述可检测试剂,并且对所述信息进行处理以进行数据采集和解释。 在某些优选的实施方案中,直接检测可检测的试剂和/或变化,而在某些其它优选的实施方案中,可检测的试剂和/或变化是借助于能够中继关于每个可产生的每种可检测试剂的信息的转导剂 的所述物质的感兴趣的液体分析物,由此所述信息被处理用于数据采集和解释。 本发明还提供了用于分析分析物的方法,包括使一种或多种分析物与上述本发明的系统接触。