Methods and systems for liquid separations

    公开(公告)号:US11628451B2

    公开(公告)日:2023-04-18

    申请号:US16364085

    申请日:2019-03-25

    IPC分类号: B04B1/20 B01D8/00 B01D17/12

    摘要: Methods and systems for separating liquid components are disclosed. A vessel is provided containing a solids conveyance device. At least a first portion of the vessel acts as an indirect-contact heat exchanger and a second portion of the vessel contains a filter. A process liquid stream, containing a first component and a second component, is passed into the first portion of the vessel. A portion of the second component is frozen and entrained in the first portion of the vessel into the process liquid stream, resulting in a process slurry stream. The process slurry stream is passed into a second portion of the vessel by the solids conveyance device. The process slurry stream is separated into a solid product stream and a primary liquid product stream by passing the primary liquid product stream through the filter and out of the vessel while separately removing the solid product stream out of the vessel.

    System and method to lyse and remove red blood cells from a cell product

    公开(公告)号:US11623034B2

    公开(公告)日:2023-04-11

    申请号:US17113297

    申请日:2020-12-07

    申请人: Fenwal, Inc.

    IPC分类号: A61M1/36 A61M1/34

    摘要: A method is provided for removing red blood cells from a suspension comprising red blood cells, white blood cells, platelets and plasma using a spinning membrane separator. The method comprises: a) flowing whole blood into the gap of the spinning membrane separator; b) collecting red blood cells and white blood cells in the gap and passing plasma and platelets through the membrane; c) introducing a first quantity of lysing buffer into the gap; d) incubating the red blood cells, white blood cells and lysing buffer in the gap for a period of time to cause a lysis reaction with the red blood cells; e) introducing a second quantity of lysing buffer into the gap to displace the first quantity of lysing buffer and a first quantity of red blood cell debris out of the gap; f) introducing a first quantity of wash buffer into the gap to quench the lysis reaction and displace the second quantity of lysing buffer and a second quantity of red blood cell debris out of the gap; and g) introducing a second quantity of wash buffer into the gap to flow washed white blood cells out of the housing.

    Optical surgical system having light sensor on its jaw and method for determining vessel size with angular distortion compensation

    公开(公告)号:US11589852B2

    公开(公告)日:2023-02-28

    申请号:US16327723

    申请日:2017-08-25

    申请人: Briteseed LLC

    摘要: A system and method for compensation of angular distortions in a system utilizing light emitters and light sensors disposed on non-parallel jaws may include determining a first point at a first side of a region of interest and a second point at a second side of the region of interest, determining a linear curve including the first and second points, and utilizing the linear curve to remove the angular distortion from the region of interest between the first and second points, A system and method for compensation of angular distortions may alternatively include modeling a non-pulsatile illumination pattern according to the intensities of individual emitters, comparing the pattern according to the model against a non-pulsatile illumination pattern detected using the light sensors, and varying the intensities of the individual emitters based on the comparison until angular distortion has been removed.

    Differential pressure filling system and method for a dosing vessel

    公开(公告)号:US11585489B2

    公开(公告)日:2023-02-21

    申请号:US15794291

    申请日:2017-10-26

    申请人: Chart Inc.

    摘要: A dosing vessel includes a reservoir having an inlet and an outlet and is configured to contain a supply of a cryogenic liquid with a headspace above. The outlet is configured to be connected to a dosing arm having a dosing head. A low pressure sensor is configured to detect a vapor pressure in the headspace. A high pressure sensor is configured to detect a pressure in a bottom portion of the reservoir. An inlet valve is in fluid communication with the inlet of the reservoir and is placed in communication with a source of cryogenic liquid. A controller is in communication with the high and low pressure sensors and the inlet valve and is configured to store a preset liquid level or a preset differential pressure corresponding to the preset liquid level, to determine a measured differential pressure based on data from the high and low pressure sensors and to control the inlet valve based on the measured differential pressure and the preset liquid level or the preset differential pressure so that a liquid level of a cryogenic liquid stored in the reservoir is generally maintained at the preset liquid level.