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    N',o-propylene phosphoric acid ester diamides
    5.
    发明授权
    N',o-propylene phosphoric acid ester diamides 失效
    N'，O-丙烯酸磷酸酯DIAMIDES

    公开(公告)号：US3732340A

    公开(公告)日：1973-05-08

    申请号：US3732340D

    申请日：1971-01-14

    申请人： ASTA WERKE AG CHEM FAB

    发明人： ARNOLD H ,  BROCK N ,  BOURSEAUX F ,  BEKEL H

    IPC分类号： C07F9/6584 ,  C07D105/04 ,  A01K27/00

    CPC分类号： C07F9/65842

    摘要： THERE ARE PROVIDED NEW N-SUBSTITUTED AMIDES AND ESTERAAMIDES OF PHOSPHORIC ACID OF THE FORMULA I:

    O
    WHEREIN R1 IS A LOWER ALKYL GROUP HAVING FROM 1 TO 4 CARBON ATOMS BEING SUBSTITUTED WITH ONE OR SEVERAL HALOGEN ATOMS, Z IS HYDROGEN OR A LOWER ALKYL GROUP HAVING FROM 1 TO 4 CARBON ATOMS, M IS 2 OR 3 AND X2 IS THE ETHYLENE IMINO GROUP OR THE GROUP HAVING THE FORMULA:

    CL-(-C(-Z)2)M-N-R

    WHEREIN R IS HYDROGEN OR A LOWER ALKYL GROUP HAVING FROM 1 TO 4 CARBON ATOMS WHICH MAY BE SUBSTITUTED WITH A CHLORINE ATOM OR A HYDROXY GROUP, AND Z AND M HAVE THE ABOVE-GIVEN MEANING. EACH OF THESE PRODUCTS IS USEFUL AS A CYTOSTATICALLY EFFECTIVE COMPOUND AND IS USED IN THE MANNER EXEMPLIFIED HEREINAFTER WITH RESPECT TO TEST ANIMALS, E.G. RATS, ACCORDING TO KNOWN TECHNIQUES FOR ADMINISTERING TEST DOSAGES.