公开(公告)号：US11506672B2

公开(公告)日：2022-11-22

申请号：US15735474

申请日：2016-06-10

申请人： ASTUTE MEDICAL, INC.

发明人： Joseph Anderberg ,  Paul McPherson ,  Jeff Gray ,  Kevin Nakamura ,  James Patrick Kampf ,  Thomas Kwan

IPC分类号： G01N33/68

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Follistatin-related protein 3, Basigin, Cathepsin B, and Tenascin as diagnostic and prognostic bio-marker assays in renal injuries.

公开(公告)号：US20220356238A1

公开(公告)日：2022-11-10

申请号：US17621414

申请日：2020-07-01

申请人： ASTUTE MEDICAL, INC.

发明人： RAVI A. VIJAYENDRAN ,  HUA WANG

IPC分类号： C07K16/24 ,  G01N33/68

摘要： The invention provides novel CCL14 antibodies useful in evaluation of renal injuries. In a broad aspect, the present invention provides antibodies which bind CCL14. The provided antibodies can find use in assays to detect CCL14, such as immunoassays with improved clinical performance. In one aspect, the CCL14 antibodies are used in therapeutic methods in which CCL14 binding is desired.

公开(公告)号：US20220236285A1

公开(公告)日：2022-07-28

申请号：US17613766

申请日：2020-05-22

申请人： ASTUTE MEDICAL, INC.

发明人： JAMES PATRICK KAMPF ,  THOMAS KWAN ,  PAUL MCPHERSON

IPC分类号： G01N33/68

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, disclosed herein are methods, compositions, and kits for detecting C-C motif chemokine 14 in combination with creatinine, urine output, and/or cystatin C for predicting the likelihood of persistent acute kidney injury as well as methods for appropriately treating a subject based on his or her assigned likelihood.

公开(公告)号：US11371096B2

公开(公告)日：2022-06-28

申请号：US15521213

申请日：2015-10-22

申请人： The George Washington University A Congressionally Chartered Not-For-Profit Corporation ,  Astute Medical, Inc.

发明人： Lakhmir S. Chawla ,  Timothy A. McCaffrey

IPC分类号： C12Q1/6883 ,  G01N33/68 ,  G01N33/566 ,  G01N33/84

摘要： The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising performing one or more assays configured to detect one or more biomarkers on a body fluid sample obtained from the subject to provide one or more assay result(s) and correlating the assay result(s) to the occurrence or nonoccurrence of appendicitis in the subject or likelihood of the future outcome to the subject.

公开(公告)号：US20220187319A1

公开(公告)日：2022-06-16

申请号：US17681493

申请日：2022-02-25

申请人： ASTUTE MEDICAL, INC.

发明人： JOSEPH ANDERBERG ,  JEFF GRAY ,  PAUL MCPHERSON ,  KEVIN NAKAMURA ,  JAMES PATRICK KAMPF

IPC分类号： G01N33/68

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin G1, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha-1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member HB, Interleukin-11, Cathepsin D, C-C motif chemokine 24, C-X-C motif chemokine 6, C-C motif chemokine 13, C-X-C motif chemokines-1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 as diagnostic and prognostic biomarkers in renal injuries.

公开(公告)号：US20220155324A1

公开(公告)日：2022-05-19

申请号：US17494773

申请日：2021-10-05

申请人： ASTUTE MEDICAL, INC.

发明人： JOSEPH ANDERBERG ,  PAUL MCPHERSON ,  JEFF GRAY ,  KEVIN NAKAMURA ,  JAMES PATRICK KAMPF ,  THOMAS KWAN

IPC分类号： G01N33/68

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Insulin-like growth factor-binding protein 2, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein 4, and Insulin like growth factor-binding protein 6 as diagnostic and prognostic biomarker assays in renal injuries.

公开(公告)号：US11262363B2

公开(公告)日：2022-03-01

申请号：US15676828

申请日：2017-08-14

申请人： ASTUTE MEDICAL, INC.

发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf

IPC分类号： G01N33/68

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin G1, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha-1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member 11B, Interleukin-11, Cathepsin D, C—C motif chemokine 24, C—X—C motif chemokine 6, C—C motif chemokine 13, C—X—C motif chemokines-1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 as diagnostic and prognostic biomarkers in renal injuries.

公开(公告)号：US11243202B2

公开(公告)日：2022-02-08

申请号：US15565318

申请日：2016-04-08

申请人： ASTUTE MEDICAL, INC. ,  UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  WESTFÄLISCHE WILHELMS—UNIVERSITÄT MÜNSTER

发明人： Paul McPherson ,  John A. Kellum, Jr. ,  Alexander Zarbock

IPC分类号： G01N33/566 ,  G01N33/68

摘要： It is an object of the present invention to provide methods for assessing the efficacy of a remote ischemic preconditioning procedure though the measurement of urinary TIMP-2 and IGFBP7 concentrations.

公开(公告)号：US20210041469A1

公开(公告)日：2021-02-11

申请号：US17079079

申请日：2020-10-23

申请人： ASTUTE MEDICAL, INC.

发明人： JOSEPH ANDERBERG ,  JEFF GRAY ,  PAUL MCPHERSON ,  KEVIN NAKAMURA ,  JAMES PATRICK KAMPF

IPC分类号： G01N33/92 ,  G01N33/68 ,  G01N33/573 ,  G01N33/74

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in sepsis patients and in patients at risk for sepsis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.

公开(公告)号：US20190339289A1

公开(公告)日：2019-11-07

申请号：US16475326

申请日：2018-01-12

申请人： ASTUTE MEDICAL, INC.

发明人： JAMES PATRICK KAMPF ,  PAUL MCPHERSON ,  DONALD CHALFIN

IPC分类号： G01N33/68

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect C-C motif chemokine 14 as diagnostic and prognostic biomarker assays in renal injuries.