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公开(公告)号：US11353465B2
公开(公告)日：2022-06-07
申请号：US16475326
申请日：2018-01-12
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect C-C motif chemokine 14 as diagnostic and prognostic biomarker assays in renal injuries.
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公开(公告)号：US11333671B2
公开(公告)日：2022-05-17
申请号：US15520817
申请日：2015-10-20
申请人： ASTUTE MEDICAL, INC.
发明人： Joseph Anderberg , Paul McPherson , Jeff Gray , Kevin Nakamura , James Patrick Kampf , Thomas Kwan
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect C—C motif chemokine 16, C—C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.
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公开(公告)号：US10794917B2
公开(公告)日：2020-10-06
申请号：US15023357
申请日：2014-09-19
申请人： ASTUTE MEDICAL, INC.
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Thomas Kwan
IPC分类号： G01N33/68
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in appendicitis patients and in patients at risk for appendicitis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients.
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公开(公告)号：US10473671B2
公开(公告)日：2019-11-12
申请号：US15537361
申请日：2015-12-18
申请人： ASTUTE MEDICAL, INC.
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.
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5.发明申请公开(公告)号：US20170363642A1
公开(公告)日：2017-12-21
申请号：US15537361
申请日：2015-12-18
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2030/8813 , G01N2333/4724 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.
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6.发明申请公开(公告)号：US20170254816A1
公开(公告)日：2017-09-07
申请号：US15604573
申请日：2017-05-24
申请人： ASTUTE MEDICAL, INC.
CPC分类号： G01N33/6893 , G01N33/6854 , G01N33/6863 , G01N33/74 , G01N2333/4725 , G01N2333/4745 , G01N2333/495 , G01N2333/521 , G01N2333/5431 , G01N2333/7155 , G01N2333/96472 , G01N2333/96494 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cancer antigen CA 15-3, C-C Motif chemokine 18, C-C Motif chemokine 24, Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.
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7.发明申请METHODS AND COMPOSITIONS FOR THE EVALUATION OF RENAL INJURY USING HYALURONIC ACID 审中-公开使用羟丙酸评估肾损伤的方法和组合公开(公告)号：US20170074868A1
公开(公告)日：2017-03-16
申请号：US15345255
申请日：2016-11-07
发明人： Joseph Anderberg , Jeff Gray , Paul McPherson , Kevin Nakamura , James Patrick Kampf , Kai Singbartl , John A. Kellum
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , G01N2400/40 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of hyaluronic acid (HA) as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用检测透明质酸（HA）中的一种或多种作为肾损伤中的诊断和预后生物标志物测定的测定法。
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8.发明申请METHODS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE USING TREFOIL FACTOR 3 FAILURE 审中-公开使用TREFOIL因子3故障诊断和预防肾损伤和肾功能衰竭的方法公开(公告)号：US20160313350A1
公开(公告)日：2016-10-27
申请号：US15137982
申请日：2016-04-25
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61B10/007 , G01N2333/47 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Trefoil factor 3 as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用检测Trefoil因子3作为肾损伤中的诊断和预后生物标志物测定的测定法。
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9.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20150241419A1
公开(公告)日：2015-08-27
申请号：US14419223
申请日：2013-08-02
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , G01N33/573 , G01N2333/90287 , G01N2800/347 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Ceruloplasmin and Annexin A2 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自由血浆铜蓝蛋白和膜联蛋白A2组成的组的肾损伤标记物作为肾损伤中的诊断和预后生物标志物。
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10.发明申请METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开用于诊断和预防肾损伤和肾功能衰竭的方法和组合公开(公告)号：US20140315752A1
公开(公告)日：2014-10-23
申请号：US14359910
申请日：2012-11-20
申请人： ASTUTE MEDICAL, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/56 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Stanniocalcin-1, Antithrombin-III, Toll-like receptor 2, Triiodothyronine (T3), Thyroxine (T4), Extracellular matrix protein 1, Coagulation factor XIII A chain, Coagulation factor XIII B chain, Interleukin-17F, Interleukin-22, Vitronectin, Progesterone, Estradiol, Growth/differentiation factor 15, and Proprotein convertase subtilisin/kexin type 9 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自下列的肾损伤标记物：丹参素c-1，抗凝血酶III，Toll样受体2，三碘甲状腺原氨酸（T3），甲状腺素（T4）， 细胞外基质蛋白1，凝血因子XIII A链，凝血因子XIII B链，白细胞介素-17F，白细胞介素-22，Vitronectin，孕酮，雌二醇，生长/分化因子15和Proprotein转化酶枯草杆菌蛋白酶/ kexin 9型作为诊断和预后生物标志物 肾损伤。
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