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    Methods and compositions for diagnosis and prognosis of renal injury and renal failure
    2.
    发明授权
    Methods and compositions for diagnosis and prognosis of renal injury and renal failure 有权

    公开(公告)号：US11262363B2

    公开(公告)日：2022-03-01

    申请号：US15676828

    申请日：2017-08-14

    申请人： ASTUTE MEDICAL, INC.

    发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf

    IPC分类号： G01N33/68

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin G1, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha-1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member 11B, Interleukin-11, Cathepsin D, C—C motif chemokine 24, C—X—C motif chemokine 6, C—C motif chemokine 13, C—X—C motif chemokines-1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 as diagnostic and prognostic biomarkers in renal injuries.

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    用于诊断和预防肾损伤和肾功能衰竭的方法和组合

    公开(公告)号：US20170016917A1

    公开(公告)日：2017-01-19

    申请号：US15284197

    申请日：2016-10-03

    申请人： ASTUTE MEDICAL, INC.

    发明人： Joseph Anderberg ,  Jeff Gray ,  Paul Mcpherson ,  Kevin Nakamura ,  James Patrick Kampf

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/60

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock 70 kDa protein 1, Alpha-1-antitrypsin Neutrophil elastase complex, Stromelysin-1:Metalloproteinase inhibitor 2 complex, 72 kDa type IV collagenase:Metalloproteinase inhibitor 2 complex, Insulin-like growth factor 1 receptor, Myeloid differentiation primary response protein MyD88, Neuronal cell adhesion molecule, and Tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自热休克70kDa蛋白1，α-1-抗胰蛋白胨中性粒细胞弹性蛋白酶复合物，溶血素蛋白酶-1：金属蛋白酶抑制剂2复合物的肾损伤标记物 ，72kDa IV型胶原酶：金属蛋白酶抑制剂2复合物，胰岛素样生长因子1受体，骨髓分化初级应答蛋白MyD88，神经元细胞粘附分子和肿瘤坏死因子配体超家族成员10作为肾损伤中的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    用于诊断和预防肾损伤和肾功能衰竭的方法和组合

    公开(公告)号：US20150355196A1

    公开(公告)日：2015-12-10

    申请号：US14761591

    申请日：2014-01-16

    申请人： ASTUTE MEDICAL, INC.

    发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf

    IPC分类号： G01N33/68 ,  G06F19/24 ,  G06F19/00 ,  G01N33/70

    CPC分类号： G01N33/6893 ,  G01N33/70 ,  G01N2333/4703 ,  G01N2333/4745 ,  G01N2333/65 ,  G01N2333/8146 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  G06F19/00 ,  G06F19/24 ,  G16H50/20 ,  Y02A90/26

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.

    摘要翻译： 本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用TIMP2和IGFBP7中的一种或多种的测量尿液浓度与测量的血清肌酐和测量的尿液输出中的一种或多种组合，其结果与受试者的肾脏状态相关，以及 可用于患有或患有肾功能损伤，肾功能减退和/或急性肾功能衰竭的受试者的诊断，预后，风险分层，分期，监测，分类和确定进一步的诊断和治疗方案。