公开(公告)号：US08566286B1

公开(公告)日：2013-10-22

申请号：US12700799

申请日：2010-02-05

申请人： Brett Derek Hawton ,  Barry John Searle ,  Daniel Aaron Hamilton

发明人： Brett Derek Hawton ,  Barry John Searle ,  Daniel Aaron Hamilton

IPC分类号： G06F17/30

CPC分类号： G06F17/30 ,  G06F11/00 ,  G06F11/1402

摘要： A system and method for backing up a database, where the system has read threads running simultaneously, write threads, and data buffers. Each read thread repeats the following operations until all the data is backed up: read a block of data from the database, compress the data using a dynamic compression ratio which is initialized and adjusted after every compression, write the data to an available data buffer until the data buffer is full, write to the next available data buffer once the data buffer is full, and determine a new compression ratio. A controller determines the new compression ratio using either a method that monitors the timing of system components and/or a method that monitors CPU consumption.

摘要翻译： 用于备份数据库的系统和方法，系统已读取线程同时运行，写入线程和数据缓冲区。 每个读取线程重复以下操作，直到所有数据被备份：从数据库读取数据块，使用动态压缩比压缩数据，该压缩比在每次压缩之后被初始化和调整，将数据写入可用数据缓冲区直到 数据缓冲区已满，一旦数据缓冲区已满，写入下一个可用的数据缓冲区，并确定新的压缩比。 控制器使用监视系统组件的定时的方法和/或监视CPU消耗的方法来确定新的压缩比。

公开(公告)号：US20050164311A1

公开(公告)日：2005-07-28

申请号：US10484859

申请日：2002-08-02

申请人： James Inglese ,  Marc Ferrer ,  Aaron Hamilton

发明人： James Inglese ,  Marc Ferrer ,  Aaron Hamilton

IPC分类号： G01N33/531 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/34 ,  C12Q1/37 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/527 ,  G01N33/53 ,  G01N33/542 ,  G01N33/573

CPC分类号： G01N33/573 ,  G01N33/542

摘要： The invention is a method for detecting a reaction product which signals the presence of a reaction product inducer such as an enzyme. The method enables the recognition of epitopes that form the basis of a detection strategy without the need for specific antibodies to the epitope. In the method, a directly or indirectly labeled modular domain and a biotinylated form of the cognate peptide ligand are used as the basis for a measurable interaction. The peptide ligand can be masked by modifications through, for example, phosphorylation of the Ser or Thr residue, or extension of the amino acid sequence beyond the C-terminal Val. Because the masked residues are critical to binding of the labeled modular domain, masking of at least one of the residues prevents binding. Upon treatment of the masked residue by the appropriate enzyme, (e.g., treatment of the phosphorylated residue with a phosphatase enzyme, or treatment of the extended residue with a protease enzyme, the peptide is converted to the original unmasked ligand that is capable of binding to the labeled modular domain and forming a measurable complex.

摘要翻译： 本发明是检测反应产物诱导剂如酶的信号的反应产物的方法。 该方法能够识别构成检测策略基础的表位，而不需要针对表位的特异性抗体。 在该方法中，使用直接或间接标记的模块结构域和生物素化形式的同源肽配体作为可测量相互作用的基础。 可以通过例如Ser或Thr残基的磷酸化或氨基酸序列延伸超过C末端Val的修饰来掩蔽肽配体。 因为掩蔽的残基对于标记的模块结构域的结合至关重要，所以至少一个残基的掩蔽防止结合。 在通过适当的酶处理掩蔽的残留物（例如用磷酸酶处理磷酸化残基或用蛋白酶处理延长的残基时），将肽转化为能够结合到 标记的模块化领域并形成可衡量的复杂。