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1.发明授权Stabilized compositions of volatile alkylating agents and methods of using thereof 有权挥发性烷基化剂的稳定组合物及其使用方法公开(公告)号：US07838564B2
公开(公告)日：2010-11-23
申请号：US12549258
申请日：2009-08-27
CPC分类号： C07C211/15 , A61K31/13 , A61K31/131 , Y10T428/13
摘要： A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
摘要翻译： 用于治疗癌症的组合物和方法。 用于治疗皮肤病症的组合物，其包含氮芥末的氮芥或HX盐，其中所述氮芥的氮芥或HX盐在不包括凡士林或乙醇的非水载体或载体中 其中不含凡士林或乙醇的非水性载体或载体不包括凡士林或乙醇。 该方法包括将氮芥末的氮芥或HX盐的组合物局部施用于受影响的皮肤，其中氮芥的氮芥或HX盐在不含凡士林的非水性载体或载体中 或乙醇，其中非水性载体或载体不包括凡士林或乙醇。
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公开(公告)号：US20090246256A1
公开(公告)日：2009-10-01
申请号：US12410114
申请日：2009-03-24
CPC分类号： A61K31/4164 , A61K9/006 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2059 , A61K31/085 , B82Y5/00
摘要： The present invention provides for compositions and methods for accelerating the rate of delivery of lofexidine to the systemic circulation by transmucosal administration through the nasal, sublingual, or buccal routes to provide rapid response in the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine, to a patient in need of such treatment. Compositions of lofexidine formulated for transmucosal delivery are provided. Also provided are methods for the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine. The methods utilize lofexidine compositions formulated for transmucosal delivery through nasal, sublingual, or buccal routes of administration in an amount effective for the treatment of the drug indications.
摘要翻译： 本发明提供组合物和方法，用于通过鼻，舌下或口腔途径通过经粘膜给药来加速洛非昔定向全身循环的递送速率，以便在治疗阿片成瘾者，偏头痛，神经性疼痛等方面提供快速反应 与洛非昔定相关的治疗适应症，需要这种治疗的患者。 提供配制用于经粘膜递送的洛非昔定组合物。 还提供了治疗阿片成瘾者，偏头痛，神经性疼痛以及与洛非昔定相关的其它治疗适应症的方法。 该方法利用配制用于通过鼻，舌下或口腔给药途径经粘膜递送的洛伏西定组合物，其用量可用于治疗药物适应症。
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3.发明申请Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof 有权挥发性烷化剂的稳定组合物及其使用方法公开(公告)号：US20080194699A1
公开(公告)日：2008-08-14
申请号：US11908531
申请日：2006-03-14
CPC分类号： C07C211/15 , A61K31/13 , A61K31/131 , Y10T428/13
摘要： A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
摘要翻译： 用于治疗癌症的组合物和方法。 用于治疗皮肤病症的组合物，其包含氮芥末的氮芥或HX盐，其中所述氮芥的氮芥或HX盐在不包括凡士林或乙醇的非水载体或载体中 其中不含凡士林或乙醇的非水性载体或载体不包括凡士林或乙醇。 该方法包括将氮芥末的氮芥或HX盐的组合物局部施用于受影响的皮肤，其中氮芥的氮芥或HX盐在不含凡士林的非水性载体或载体中 或乙醇，其中非水性载体或载体不包括凡士林或乙醇。
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公开(公告)号：US20110150946A1
公开(公告)日：2011-06-23
申请号：US13060118
申请日：2009-08-21
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： The present invention relates generally to methods for transdermal delivery of a therapeutically effective amount of apomorphine using microneedles. The invention also provides methods for treatment of erectile dysfunction and Parkinson's disease using apomorphine hydrochloride or any pharmaceutically acceptable salt, and/or apomorphine prodrugs to the microneedle-treated site.
摘要翻译： 本发明一般涉及使用微针透皮递送治疗有效量的阿朴吗啡的方法。 本发明还提供了使用阿朴吗啡盐酸盐或任何药学上可接受的盐和/或阿扑吗啡前药治疗勃起功能障碍和帕金森病的方法，用于微针治疗部位。
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5.发明申请Skin Patches and Sustained-Release Formulations Comprising Lofexidine for Transdermal and Oral Delivery 审中-公开包含Lofexidine用于经皮和口服输送的皮肤贴剂和持续释放制剂公开(公告)号：US20110097393A1
公开(公告)日：2011-04-28
申请号：US12999659
申请日：2009-06-25
IPC分类号： A61K9/127 , A61K31/4164 , A61K9/70 , A61K9/48 , A61K31/439 , A61K31/4355 , A61K31/55 , A61P25/04 , A61P25/32 , A61P25/36 , A61M37/00
CPC分类号： A61K9/0002 , A61K9/0014 , A61K9/0021 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/7084 , A61K31/4164 , A61K45/06 , A61K47/10 , A61K47/38 , A61K2300/00
摘要： This invention relates to a sustained release oral and transdermal pharmaceutical formulations and delivery systems comprising lofexidine. The invention is also directed to methods of treatment comprising administering lofexidine in a sustained release manner. Such methods can involve administration of the lofexidine containing compositions described herein. Compositions of lofexidine formulated for sustained release delivery are provided. Also provided are methods for the treatment of opiate addicts, migraine, neuropathic pain, and other therapeutic indications related to lofexidine. The methods may provide treatment for a variety of conditions amenable to amelioration by lofexidine administration. The methods utilize lofexidine compositions formulated for transdermal and sustained release oral delivery for administration of lofexidine in an amount effective for the treatment of the drug indications.
摘要翻译： 本发明涉及包含洛哌啶的缓释口服和透皮药物制剂和递送系统。 本发明还涉及治疗方法，其包括以持续释放的方式施用洛非沙星。 这些方法可涉及施用本文所述的含有洛伏定的组合物。 提供配制用于持续释放递送的洛非昔定组合物。 还提供了治疗阿片成瘾者，偏头痛，神经性疼痛以及与洛非昔定相关的其它治疗适应症的方法。 所述方法可以提供适于通过洛哌啶给药改善的各种病症的治疗。 该方法利用配制用于经皮和持续释放口服递送的洛伏西定组合物，其用量可用于治疗药物适应症的量。
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公开(公告)号：US20090246273A1
公开(公告)日：2009-10-01
申请号：US12410928
申请日：2009-03-25
IPC分类号： A61K9/127 , A61K9/14 , A61K9/12 , A61K31/407
CPC分类号： A61K31/407 , A61K9/006 , A61K9/12
摘要： The present invention provides for compositions and methods for accelerating the rate of delivery of ketorolac to the systemic circulation by sublingual spray administration under the tongue to provide a rapid response in the treatment of pain, especially acute pain associated with postoperative pain and migraine headache. Compositions of ketorolac formulated for sublingual delivery as liquid spray are provided. Also provided are methods of treatment and management of pain.
摘要翻译： 本发明提供组合物和方法，用于通过舌下舌下喷雾施用来加速将酮咯酸递送至全身循环的速率，以提供治疗疼痛，特别是与术后疼痛和偏头痛头痛相关的急性疼痛的快速反应。 提供配制用于舌下递送作为液体喷雾的酮咯酸的组合物。 还提供了治疗和治疗疼痛的方法。
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7.发明授权Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents 有权辅助溶剂组合物和用于改善丹特罗林治疗剂递送的方法公开(公告)号：US08975284B2
公开(公告)日：2015-03-10
申请号：US12205303
申请日：2008-09-05
IPC分类号： A01N43/40 , A61K31/44 , A01N43/50 , A61K31/415 , A01N43/00 , A61K31/33 , A61K9/00 , A61K9/08 , A61K9/19 , A61K31/4166 , A61K31/4168
CPC分类号： A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4166 , A61K31/4168
摘要： The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
摘要翻译： 本发明提供了使用叔丁醇（TBA）共溶剂体系制备和生产低溶解度的药剂的方法。 本发明还提供了使用新型共溶剂体系制备的药物组合物。 在一个实施方案中，本发明提供了制备用于静脉内使用的丹曲林钠（DS）制剂的方法（DS-IV）。 DS-IV产品的这种即时重建对于在手术期间接受恶性高热的患者的药物治疗是一个显着的改善。
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8.发明授权Stabilized compositions of volatile alkylating agents and methods of using thereof 有权挥发性烷基化剂的稳定组合物及其使用方法公开(公告)号：US08450375B2
公开(公告)日：2013-05-28
申请号：US11908531
申请日：2006-03-14
CPC分类号： C07C211/15 , A61K31/13 , A61K31/131 , Y10T428/13
摘要： A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
摘要翻译： 用于治疗癌症的组合物和方法。 用于治疗皮肤病症的组合物，其包含氮芥末的氮芥或HX盐，其中所述氮芥的氮芥或HX盐在不包括凡士林或乙醇的非水载体或载体中 其中不含凡士林或乙醇的非水性载体或载体不包括凡士林或乙醇。 该方法包括将氮芥末的氮芥或HX盐的组合物局部施用于受影响的皮肤，其中氮芥的氮芥或HX盐在不含凡士林的非水性载体或载体中 或乙醇，其中非水性载体或载体不包括凡士林或乙醇。
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公开(公告)号：US20120040970A1
公开(公告)日：2012-02-16
申请号：US13266358
申请日：2010-04-26
IPC分类号： A61K31/4178 , A61P3/00 , A61P25/00 , A61K31/551 , A61K31/451
CPC分类号： A61K31/4166 , A61K9/0043
摘要： The present invention provides a method for rapidly and reliably delivering dantrolene, or derivatives thereof, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment or prevention of malignant hyperthermia (MH), spasticity, and Ecstasy intoxication. The present invention further provides intranasal pharmaceutical compositions comprising dantrolene sodium or any pharmaceutically acceptable salts thereof in a variety of pharmaceutical dosage forms, with and without other compounds.
摘要翻译： 本发明提供了一种通过鼻道途径将丹曲林或其衍生物单独或与其它化合物组合快速可靠地递送至全身循环的方法，以便在治疗或预防恶性高热方面快速发挥有益作用 （MH），痉挛和迷魂药中毒。 本发明还提供了包含丹曲林钠或其各种药物剂型中的任何药学上可接受的盐的鼻内药物组合物，其具有和不具有其它化合物。
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10.发明申请STABILIZED COMPOSITIONS OF VOLATILE ALKYLATING AGENTS AND METHODS OF USING THEREOF 有权挥发性碱性化合物的稳定组合物及其使用方法公开(公告)号：US20100041767A1
公开(公告)日：2010-02-18
申请号：US12549258
申请日：2009-08-27
IPC分类号： A61K31/13
CPC分类号： C07C211/15 , A61K31/13 , A61K31/131 , Y10T428/13
摘要： A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.
摘要翻译： 用于治疗癌症的组合物和方法。 用于治疗皮肤病症的组合物，其包含氮芥末的氮芥或HX盐，其中所述氮芥的氮芥或HX盐在不包括凡士林或乙醇的非水载体或载体中 其中不含凡士林或乙醇的非水性载体或载体不包括凡士林或乙醇。 该方法包括将氮芥末的氮芥或HX盐的组合物局部施用于受影响的皮肤，其中氮芥的氮芥或HX盐在不含凡士林的非水性载体或载体中 或乙醇，其中非水性载体或载体不包括凡士林或乙醇。
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