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公开(公告)号:US08969571B2
公开(公告)日:2015-03-03
申请号:US14087404
申请日:2013-11-22
申请人: Mathai Mammen , Adam Hughes , Yan Chen
发明人: Mathai Mammen , Adam Hughes , Yan Chen
IPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/94
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译: 本发明提供式I的联苯衍生物:其中R1,R2,R3,R4,R5,R6,R7,W,a,b和c如说明书中所定义,或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的联苯衍生物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这种联苯衍生物可用于治疗肺部疾病,如慢性阻塞性肺疾病和哮喘。
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公开(公告)号:US20120309985A1
公开(公告)日:2012-12-06
申请号:US13588697
申请日:2012-08-17
IPC分类号: C07D207/08 , C07D405/06 , C07D207/09
CPC分类号: A61K31/40 , A61K31/4025 , C07D207/08 , C07D405/06
摘要: In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译: 一方面,本发明涉及式I的化合物:其中R1-6如说明书中所定义,或其药学上可接受的盐。 式I化合物是5-羟色胺和去甲肾上腺素再摄取抑制剂。 另一方面,本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号:US08264368B2
公开(公告)日:2012-09-11
申请号:US12543002
申请日:2009-08-18
申请人: Adam Hughes , Des Walker , Ian Maguire , David May
发明人: Adam Hughes , Des Walker , Ian Maguire , David May
IPC分类号: G08B5/22
CPC分类号: F41G1/35 , F41H13/0087 , G02B27/20
摘要: A warning unit for attachment to a handheld firearm comprises an attachment device for attachment to a firearm, a light source, and a digitally manipulable input device operable to enable selection of a mode of operation. The warning unit is capable of being operated in at least a narrow divergence mode, and a wide divergence mode wherein, in the narrow divergence mode, the warning unit is operable to emit a beam of light of a lower divergence than in the wide divergence mode.
摘要翻译: 用于附接到手持式火器的警告单元包括用于附接到枪支的附接装置,光源和可操作以使得能够选择操作模式的数字可操纵的输入装置。 警报单元能够以至少窄的发散模式和宽的发散模式操作,其中在窄发散模式中,警告单元可操作地发射比在宽散度模式中的低发散光束 。
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4.
公开(公告)号:US20100197667A1
公开(公告)日:2010-08-05
申请号:US12759887
申请日:2010-04-14
申请人: Yu-Hua JI , Mathai MAMMEN , Craig HUSFELD , Li LI , YongQi MU , Aaron KUSHNER , Eric STANGELAND , Trevor MISCHKI , Adam HUGHES , Sarah DUNHAM
发明人: Yu-Hua JI , Mathai MAMMEN , Craig HUSFELD , Li LI , YongQi MU , Aaron KUSHNER , Eric STANGELAND , Trevor MISCHKI , Adam HUGHES , Sarah DUNHAM
IPC分类号: A61K31/445 , C07D211/48 , C07D401/12 , C07D405/12 , C07D413/12 , C07D409/12 , C07D487/04 , C07D401/14 , C07D413/14 , C07D417/12 , A61K31/496 , A61K31/4525 , A61K31/4545 , A61K31/4535 , A61K31/5377 , A61K31/551
CPC分类号: C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译: 本发明提供式I化合物:其中a,b,c,m,s,t,w,Z,Ar,R 1,R 2,R 3,R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物,用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号:US07521561B2
公开(公告)日:2009-04-21
申请号:US11449004
申请日:2006-06-07
申请人: Mathai Mammen , Adam Hughes , Yan Chen
发明人: Mathai Mammen , Adam Hughes , Yan Chen
IPC分类号: C07D215/38 , A61K31/44
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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公开(公告)号:US07514558B2
公开(公告)日:2009-04-07
申请号:US11604607
申请日:2006-11-27
申请人: Mathai Mammen , Adam Hughes , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Adam Hughes , Eric Stangeland , Yan Chen
IPC分类号: A61K31/44 , C07D215/38
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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公开(公告)号:US07507751B2
公开(公告)日:2009-03-24
申请号:US11888526
申请日:2007-08-01
申请人: Mathai Mammen , Adam Hughes , Yan Chen
发明人: Mathai Mammen , Adam Hughes , Yan Chen
IPC分类号: A61K31/47
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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公开(公告)号:US07317102B2
公开(公告)日:2008-01-08
申请号:US10813745
申请日:2004-03-31
申请人: Mathai Mammen , Adam Hughes
发明人: Mathai Mammen , Adam Hughes
IPC分类号: C07D215/12 , C07D215/16
CPC分类号: C07D401/12 , C07D207/04 , C07D207/09 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14
摘要: This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译: 本发明提供了式I化合物:其中R 1,R 2,R 3,R 4,R 4, R 5,R 6,R 7,Ar 1,Ar 2,E 2, ,a,b,c和z如说明书中所定义,或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的化合物具有β2/2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这些化合物可用于治疗肺部疾病,如慢性阻塞性肺疾病和哮喘。
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公开(公告)号:US20070078163A1
公开(公告)日:2007-04-05
申请号:US11602802
申请日:2006-11-21
申请人: Mathai Mammen , Adam Hughes , Yu-hua Ji , Li Li , Weijiang Zhang
发明人: Mathai Mammen , Adam Hughes , Yu-hua Ji , Li Li , Weijiang Zhang
IPC分类号: A61K31/445 , A61K31/40 , C07D211/26 , C07D207/30 , C07C269/02
CPC分类号: C07D207/08 , A61K31/40 , C07D207/09 , C07D207/16 , C07D211/34
摘要: This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The invention also directed to pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors using such compounds.
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公开(公告)号:US20060229334A1
公开(公告)日:2006-10-12
申请号:US11449004
申请日:2006-06-07
申请人: Mathai Mammen , Adam Hughes , Yan Chen
发明人: Mathai Mammen , Adam Hughes , Yan Chen
IPC分类号: A61K31/4709 , A61K31/445 , C07D401/02 , C07D211/54
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译: 本发明提供式I的联苯衍生物:其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,W,a,b和c如说明书中所定义,或其药学上可接受的盐或 其溶剂合物或立体异构体。 本发明的联苯衍生物具有β2N2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这种联苯衍生物可用于治疗肺部疾病,如慢性阻塞性肺病和哮喘。
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