-
公开(公告)号：US20060240028A1
公开(公告)日：2006-10-26
申请号：US10511990
申请日：2003-04-21
CPC分类号： C07K16/1072 , A61K38/00 , A61K2039/505 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2318/10
摘要： The present invention relates to a substance that specifically binds a nuclear localization signal (NLS)-containing molecule. Said substance may be a naturally occurring, synthetic or recombinant antibody, or it may be a protein, a peptide or a small molecule. Preferably, said NLS-containing molecule is a HIV-1 protein, more preferably Vpr or Tat. In addition, the present invention relates to a composition or a vaccine comprising the substance of the invention, as well as methods of inhibiting viral infection through the administration thereof.
摘要翻译： 本发明涉及特异性结合含核定位信号（NLS）的分子的物质。 所述物质可以是天然存在的，合成的或重组的抗体，或者它可以是蛋白质，肽或小分子。 优选地，所述含有NLS的分子是HIV-1蛋白质，更优选为Vpr或Tat。 此外，本发明涉及包含本发明物质的组合物或疫苗，以及通过其施用来抑制病毒感染的方法。
-
公开(公告)号：US20060008464A1
公开(公告)日：2006-01-12
申请号：US10508959
申请日：2003-04-03
CPC分类号： A61K47/645 , A61K47/62 , A61K47/643
摘要： A conjugate of a histone moiety covalently attached to a macromolecule-of-interest, in which the histone moiety is transportable through the cell membrane and importable into the cell nuclei, is disclosed. Further disclosed are chemical and recombinant methods of preparing such a conjugate, pharmaceutical compositions containing same and uses thereof for delivering therapeutically active macromolecules into cells. A novel method for quantitatively determining a cytoplasmic uptake and/or a nuclear uptake of a moiety into cells is also disclosed.
摘要翻译： 公开了共价连接到感兴趣的大分子的组蛋白部分的缀合物，其中组蛋白部分可通过细胞膜传输并可导入细胞核。 进一步公开的是制备这种缀合物的化学和重组方法，含有它的药物组合物和用于将治疗活性大分子递送到细胞中的用途。 还公开了用于定量测定部分细胞的细胞质摄取和/或核摄取的新方法。
-
搜索结果
2 条记录 (耗时 0.013 秒)
