公开(公告)号：US06586577B2

公开(公告)日：2003-07-01

申请号：US09912962

申请日：2001-07-25

申请人： Titia De Lange ,  Dominique Broccoli ,  Agata Smogorzenska

发明人： Titia De Lange ,  Dominique Broccoli ,  Agata Smogorzenska

IPC分类号： C07H2104

CPC分类号： G01N33/68 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00

摘要： The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included within the invention are expression vectors for the production of the telomeric protein and host cells transformed with the nucleotide sequence. In addition, antibodies, probes and antagonists specific for the telomeric protein are contemplated. Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer, are also contemplated.

公开(公告)号：US06297356B1

公开(公告)日：2001-10-02

申请号：US09018635

申请日：1998-02-04

申请人： Titia DeLange ,  Dominique Broccoli ,  Agata Smogorzenska

发明人： Titia DeLange ,  Dominique Broccoli ,  Agata Smogorzenska

IPC分类号： C07K1300

CPC分类号： G01N33/68 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00

摘要： The present invention relates to a novel nucleotide sequence encoding a telomeric protein which binds a repeat region of telomeric sequences, and to the protein encoded thereby. Also included within the invention are expression vectors for the production of the telomeric protein and host cells transformed with the nucleotide sequence. In addition, antibodies, probes and antagonists specific for the telomeric protein are contemplated. Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer, are also contemplated.

摘要翻译： 本发明涉及一种编码端粒蛋白的新型核苷酸序列，其结合端粒序列的重复区域以及由此编码的蛋白质。 本发明还包括用于产生端粒蛋白和用核苷酸序列转化的宿主细胞的表达载体。 此外，考虑了对端粒蛋白特异性的抗体，探针和拮抗剂。 确定端粒蛋白拮抗剂的方法，鉴定样品中端粒蛋白的诊断方法以及端粒蛋白的治疗用途，特别是治疗老化和癌症的方法。