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公开(公告)号:US20120114557A1
公开(公告)日:2012-05-10
申请号:US13229900
申请日:2011-09-12
申请人: Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
发明人: Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
CPC分类号: A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译: 描述用于成像和/或评估胶原的诊断组合物和方法。 诊断组合物可以包括胶原结合肽。
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公开(公告)号:US20220396631A1
公开(公告)日:2022-12-15
申请号:US17595637
申请日:2020-05-19
申请人: Lu HUANG , Brian GRANDA , John BLANKENSHIP , Aida ABUJOUB , Tony FLEMING , Haihui LU , Connie HONG , Brian HOLMBERG , Novartis AG
发明人: Brian Walter Granda , John Blankenship , Aida Abujoub , Tony Fleming , Lu Huang , Connie Hong , Brian Holmberg , Haihui Lu
IPC分类号: C07K16/28
摘要: The present disclosure provides multispecific binding molecules that specifically bind to BCMA, a component of a human T-cell receptor complex and either CD2 or a tumor associated antigen, conjugates comprising the multispecific binding molecules, and pharmaceutical compositions comprising the multispecific binding molecules and the conjugates The disclosure further provides methods of using the multispecific binding molecules to treat disease and disorders associated with expression of BCMA. The disclosure yet further provides recombinant host cells engineered to express the multispecific binding molecules and methods of producing the multispecific binding molecules by culturing the host cells under conditions in which the multispecific binding molecules are expressed.
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公开(公告)号:US20080044360A1
公开(公告)日:2008-02-21
申请号:US11618458
申请日:2006-12-29
申请人: Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
发明人: Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
CPC分类号: A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译: 描述用于成像和/或评估胶原的诊断组合物和方法。 诊断组合物可以包括胶原结合肽。
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公开(公告)号:US08034898B2
公开(公告)日:2011-10-11
申请号:US11618458
申请日:2006-12-29
申请人: Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
发明人: Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
IPC分类号: C07K7/52
CPC分类号: A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译: 描述用于成像和/或评估胶原的诊断组合物和方法。 诊断组合物可以包括胶原结合肽。
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公开(公告)号:US09386938B2
公开(公告)日:2016-07-12
申请号:US13229900
申请日:2011-09-12
申请人: Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
发明人: Peter D. Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Kumar Das , Vincent Jacques , Richard Looby , Steffi K. Koerner , Wei-Chuan Sun , David R. Buckler , Aida Abujoub , Aaron K. Sato
CPC分类号: A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要: Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译: 描述用于成像和/或评估胶原的诊断组合物和方法。 诊断组合物可以包括胶原结合肽。
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公开(公告)号:US20080058636A1
公开(公告)日:2008-03-06
申请号:US11618556
申请日:2006-12-29
申请人: Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
发明人: Peter Caravan , Andrew Kolodziej , Zhaoda Zhang , Stephane Dumas , Biplab Das , Vincent Jacques , Richard Looby , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
CPC分类号: A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要: Diagnostic compositions and methods for imaging collagen and/or assessing myocardial perfusion are described. The diagnostic compositions can include collagen binding peptides.
摘要翻译: 描述用于胶原成像和/或评估心肌灌注的诊断组合物和方法。 诊断组合物可以包括胶原结合肽。
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公开(公告)号:US20070293656A1
公开(公告)日:2007-12-20
申请号:US11618564
申请日:2006-12-29
申请人: Peter Caravan , Andrew Kolodziej , Biplab Das , Zhaoda Zhang , Stephane Dumas , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
发明人: Peter Caravan , Andrew Kolodziej , Biplab Das , Zhaoda Zhang , Stephane Dumas , Steffi Koerner , Wei-Chuan Sun , David Buckler , Aida Abujoub , Aaron Sato
IPC分类号: C07K14/78
CPC分类号: A61B5/055 , A61B5/4519 , A61B5/7289 , A61B5/7292
摘要: Peptides capable of binding to extracellular matrix proteins, such as collagen, are described, including their use in diagnostic and therapeutic applications.
摘要翻译: 描述了能够结合细胞外基质蛋白(例如胶原)的肽,包括其在诊断和治疗应用中的用途。
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