公开(公告)号：US20110152352A1

公开(公告)日：2011-06-23

申请号：US12997402

申请日：2009-06-10

申请人： Akiko Hata ,  Brandi Davis ,  Giorgio Lagna

发明人： Akiko Hata ,  Brandi Davis ,  Giorgio Lagna

IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N15/63 ,  C12N7/01 ,  C12N5/071 ,  C40B40/06 ,  A61P35/00

CPC分类号： C12N15/111 ,  C12N2310/113 ,  C12N2310/13 ,  C12N2310/321 ,  C12N2310/3513 ,  C12N2320/50 ,  C12N2310/3521

摘要： The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention relates, to oligonucleotides comprising a CAGRN-motif that modulate expression of miRNAs that are regulated by TGF-β/BMP signaling pathway. The invention, in some aspects, relates to composition and methods useful for inhibiting microRNA processing. In some aspects, the invention relates to composition and methods for treating TGF-Beta/BMP mediated disorders.

摘要翻译： 在一些方面，本发明涉及可用于调节由TGF-β/ BMP信号通路调节的miRNA表达的组合物和方法。 在一些方面，本发明涉及包含调节由TGF-β/ BMP信号通路调节的miRNA的表达的CAGRN-基序的寡核苷酸。 本发明在某些方面涉及可用于抑制微小RNA加工的组合物和方法。 在一些方面，本发明涉及用于治疗TGF-β/ BMP介导的病症的组合物和方法。

公开(公告)号：US5962977A

公开(公告)日：1999-10-05

申请号：US994938

申请日：1997-12-19

申请人： Keiichi Matsumoto ,  Yukiharu Tagawa ,  Toyohiko Kumada ,  Makoto Fujii ,  Akiko Hata

发明人： Keiichi Matsumoto ,  Yukiharu Tagawa ,  Toyohiko Kumada ,  Makoto Fujii ,  Akiko Hata

IPC分类号： H01J61/067 ,  H01J1/14

CPC分类号： H01J61/0677

摘要： A low pressure discharge lamp in which, even during uninterrupted operation, a low lamp voltage characteristic is maintained over a long time interval and in which high radiant efficiency can be obtained over a long time is achieved via a low pressure discharge lamp which has a tubular glass bulb in which a pair of electrodes are located opposite one another, by an electron emission material which contains lithium being included on or in the electrode substrate. Advantageously, the electron emission material contains at least one of the following materials: metallic lithium, an alloy of lithium and another metal, an oxide of lithium, a mixture of an oxide of lithium with another metal oxide, and an oxide which contains lithium and another metal element and which is a compound identified by the formula Li--M--O.sub.x where M designates at least one element selected from among the alkali earth metals, rare earth metals and transition metal, and x is the number of oxygen atoms required for valency equalization.

摘要翻译： 一种低压放电灯，其中，即使在不间断的操作中，长时间间隔地保持低的灯电压特性，并且通过具有管状的低压放电灯可以长时间获得高的辐射效率 通过电子发射材料，其中一对电极彼此相对定位，其中包含锂的电子发射材料包括在电极基底中或电极基底中。 有利地，电子发射材料包含以下材料中的至少一种：金属锂，锂和另一种金属的合金，锂的氧化物，锂与另一种金属氧化物的混合物和含有锂的氧化物 另一种金属元素，它是由式Li-M-Ox表示的化合物，其中M表示选自碱土金属，稀土金属和过渡金属中的至少一种元素，x是化合价所需的氧原子数 均衡