公开(公告)号：US5658918A

公开(公告)日：1997-08-19

申请号：US409054

申请日：1995-03-23

申请人： Kaoru Okamoto ,  Taisuke Hasegawa ,  Akio Namimatsu

发明人： Kaoru Okamoto ,  Taisuke Hasegawa ,  Akio Namimatsu

IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P11/02 ,  A61P27/16 ,  C07D473/28

CPC分类号： C07D473/28

摘要： The present invention provides purine derivatives and pharmaceutically acceptable salts thereof which exhibit an inhibitory action towards nasal mucus secretion and are useful as pharmaceuticals for treatment of nasal secretion and rhinitis. The purine derivatives are represented by the following general formula: ##STR1## wherein R is alkyl or cycloalkyl, or optionally-substituted phenyl or phenylalkyl; R' is hydrogen or --COOX; and X is alkyl, alkenyl, alkoxyalkyl, phenyl or phenylalkyl. The compounds are useful as therapeutic and preventive agents for various types of rhinitis accompanied by acceleration of nasal mucus secretion and by the sneezing reflex such as allergic rhinitis. The compounds may be administered orally and exhibit low toxicity, little side effect and high safety. Accordingly, continuous long term administration of the pharmaceutical compositions may be performed for highly effective treatment of rhinitis.

摘要翻译： 本发明提供嘌呤衍生物及其药学上可接受的盐，其对鼻粘液分泌具有抑制作用，并且可用作治疗鼻分泌和鼻炎的药物。 嘌呤衍生物由以下通式表示：其中R是烷基或环烷基或任选取代的苯基或苯基烷基; R'是氢或-COOX; X是烷基，烯基，烷氧基烷基，苯基或苯基烷基。 这些化合物可用作各种类型的鼻炎的治疗和预防剂，伴随着加速鼻粘液分泌和喷鼻反射如过敏性鼻炎。 化合物可以口服给药，毒性低，副作用小，安全性高。 因此，可以进行药物组合物的连续长期给药以高效治疗鼻炎。

公开(公告)号：US4996988A

公开(公告)日：1991-03-05

申请号：US247280

申请日：1988-09-21

申请人： Hiroyuki Ohhara ,  Akio Namimatsu ,  Hirohide Matsuura

发明人： Hiroyuki Ohhara ,  Akio Namimatsu ,  Hirohide Matsuura

IPC分类号： G01N33/48 ,  G01N33/15 ,  G01N33/50 ,  A61B5/00

CPC分类号： G01N33/5088

摘要： This invention provides a method of determining the behavior of drugs in living bodies, particularly those which contain a variety of active ingredients, like biological, natural drug and crude-drug preparations. It comprises administering a drug being tested to an animal, taking a blood sample from that animal, deproteinizing the plasma separated from the blood, intravenously administering the deproteinized plasma thus prepared to a different test animal, and examining the effect of drug exhibited in that test animal. The amount of active ingredients absorbed into the blood can be estimated by this indirect method even with special drugs including a variety of unknown and trace components.

公开(公告)号：US5063045A

公开(公告)日：1991-11-05

申请号：US506039

申请日：1990-04-09

申请人： Akio Namimatsu ,  Kouichiro Go

发明人： Akio Namimatsu ,  Kouichiro Go

IPC分类号： A61K49/00 ,  G01N33/50

CPC分类号： A61K49/0043 ,  G01N33/5088 ,  Y10S514/826

摘要： Antiallergic substances, are evaluated by measuring the amount of nasal secretion quantitatively using experimental animal models with nasal mucosal hypersensitivity.

摘要翻译： 通过使用具有鼻粘膜超敏反应的实验动物模型定量测量鼻分泌量来评估抗过敏物质。