公开(公告)号：US4808618A

公开(公告)日：1989-02-28

申请号：US35797

申请日：1987-04-08

申请人： Kouichiro Go ,  Yoshiyuki Kurimoto ,  Norihiko Kitamura

发明人： Kouichiro Go ,  Yoshiyuki Kurimoto ,  Norihiko Kitamura

IPC分类号： A61K31/505 ,  A61P37/08 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to a novel pyrido[4,3-d]pyrimidine derivative having the formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a lower alkyl group; R.sub.3 is hydrogen, halogen, hydroxy, amino, hydroxyamino, imino, hydrazino or a lower alkylamino group which may optionally have hydroxy, amino or a lower alkylamino group; and R.sub.4 is hydrogen, amino, --NH.sup..crclbar. or a lower alkyl group which may optionally have hydroxy, amino or a lower alkylamino group; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

摘要翻译： 本发明涉及具有式（I）的新颖的吡啶并[4,3-d]嘧啶衍生物：其中R1和R2可以相同或不同，为低级烷基 ; R 3是氢，卤素，羟基，氨基，羟基氨基，亚氨基，肼基或可任选具有羟基，氨基或低级烷基氨基的低级烷基氨基; 和R 4是氢，氨基，-NH（ - ）或可任选具有羟基，氨基或低级烷基氨基的低级烷基; 及其药学上可接受的盐。 这些化合物可用作抗过敏剂，例如用于治疗支气管哮喘，荨麻疹，过敏性鼻炎，过敏性皮肤病或过敏性结膜炎。

公开(公告)号：US5063045A

公开(公告)日：1991-11-05

申请号：US506039

申请日：1990-04-09

申请人： Akio Namimatsu ,  Kouichiro Go

发明人： Akio Namimatsu ,  Kouichiro Go

IPC分类号： A61K49/00 ,  G01N33/50

CPC分类号： A61K49/0043 ,  G01N33/5088 ,  Y10S514/826

摘要： Antiallergic substances, are evaluated by measuring the amount of nasal secretion quantitatively using experimental animal models with nasal mucosal hypersensitivity.

摘要翻译： 通过使用具有鼻粘膜超敏反应的实验动物模型定量测量鼻分泌量来评估抗过敏物质。

公开(公告)号：US4808587A

公开(公告)日：1989-02-28

申请号：US35798

申请日：1987-04-08

申请人： Kouichiro Go ,  Yoshiyuki Kurimoto ,  Norihiko Kitamura

发明人： Kouichiro Go ,  Yoshiyuki Kurimoto ,  Norihiko Kitamura

IPC分类号： A61K31/505 ,  A61P37/08 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to a novel pyrido[2,3-d]pyrimidine derivative having the formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a lower alkyl group; and each of R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, halogen, hydroxy, nitro, amino, hydroxyamino, hydrazino, azido, a lower alkenylamino group or a lower alkylamino group which may optionally have hydroxy; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

摘要翻译： 本发明涉及具有式（I）的新颖的吡啶并[2,3-d]嘧啶衍生物：其中R1和R2可以相同或不同，为低级烷基 ; 可以相同或不同的R 3和R 4可以是氢，卤素，羟基，硝基，氨基，羟基氨基，肼基，叠氮基，低级链烯基氨基或可以具有羟基的低级烷基氨基; 及其药学上可接受的盐。 这些化合物可用作抗过敏剂，例如用于治疗支气管哮喘，荨麻疹，过敏性鼻炎，过敏性皮肤病或过敏性结膜炎。