公开(公告)号：US09084820B2

公开(公告)日：2015-07-21

申请号：US12937843

申请日：2009-04-20

Applicant: Gary Zabow ,  Stephen Dodd ,  Alan Koretsky ,  John Moreland

Inventor： Gary Zabow ,  Stephen Dodd ,  Alan Koretsky ,  John Moreland

IPC: A61K49/18 ,  A61B5/055 ,  G01R33/12 ,  G01R33/28 ,  G01R33/56 ,  G01R33/563 ,  H01F10/14 ,  G01R33/34

CPC classification number: A61K49/1896 ,  A61B5/055 ,  A61K49/18 ,  G01R33/1269 ,  G01R33/281 ,  G01R33/34007 ,  G01R33/34084 ,  G01R33/5601 ,  G01R33/5605 ,  G01R33/5607 ,  G01R33/56366 ,  H01F10/14

Abstract: A magnetic resonance contrast agent has a medium, and a contrast structure dispersed in the medium. The contrast structure comprises a magnetic material arranged to create a local region of a local magnetic field such that nuclear magnetic moments of a material when arranged within the local region precess at a characteristic Larmor frequency about a total magnetic field in the local region while in use, the characteristic Larmor frequency being identifiable with the contrast structure, and the total magnetic field in the local region being a substantially spatially uniform magnetic field.

Abstract translation: 磁共振造影剂具有分散在介质中的介质和对比度结构。 对比结构包括磁性材料，其被布置成产生局部磁场的局部区域，使得当被布置在本地区域内的材料的核磁矩在特征拉莫尔频率下在使用中在局部区域内约总磁场强度 特征拉莫尔频率可以用对比度结构识别，并且局部区域中的总磁场是基本上空间上均匀的磁场。

公开(公告)号：US20170067974A1

公开(公告)日：2017-03-09

申请号：US15309336

申请日：2015-05-07

Applicant: Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky ,  OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

Inventor： Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky

IPC: G01R33/36 ,  G01R33/561

CPC classification number: G01R33/3621 ,  G01R33/3642 ,  G01R33/3692 ,  G01R33/5616

Abstract: A novel MRI-compatible amplifier design uses positive feedback from a low-noise Field-Effect Transistor to amplify the signal current within a resonant NMR coil. The amplified signal current in this low-power circuit produces RF flux can be coupled out to receiving loops positioned externally without significant loss in sensitivity. In other aspects, the amplifier may be remotely powered by external resonant loops, a small non-magnetic battery, or optical power, such that the NMR coil can be positioned during highly invasive procedures such as for surgical resection of tumors in deep-lying tissues to develop high-resolution images.

Abstract translation: 一种新颖的MRI兼容放大器设计使用来自低噪声场效应晶体管的正反馈来放大谐振NMR线圈内的信号电流。 该低功率电路中放大的信号电流产生的RF通量可以耦合到外部定位的接收回路，而灵敏度没有显着的损失。 在其他方面，放大器可以由外部谐振回路，小型非磁性电池或光学功率远程供电，使得NMR线圈可以在高侵入性程序中定位，例如用于在深层组织中手术切除肿瘤 开发高分辨率图像。

公开(公告)号：US10393831B2

公开(公告)日：2019-08-27

申请号：US15309336

申请日：2015-05-07

Applicant: Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky ,  OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH

Inventor： Joseph A. Murphy-Boesch ,  Stephen Dodd ,  Chunqi Qian ,  Alan Koretsky

IPC: G01R33/36 ,  G01R33/561

Abstract: A novel MRI-compatible amplifier design uses positive feedback from a low-noise Field-Effect Transistor to amplify the signal current within a resonant NMR coil. The amplified signal current in this low-power circuit produces RF flux can be coupled out to receiving loops positioned externally without significant loss in sensitivity. In other aspects, the amplifier may be remotely powered by external resonant loops, a small non-magnetic battery, or optical power, such that the NMR coil can be positioned during highly invasive procedures such as for surgical resection of tumors in deep-lying tissues to develop high-resolution images.

公开(公告)号：US20140066753A1

公开(公告)日：2014-03-06

申请号：US14008133

申请日：2012-03-29

Applicant: Chunqi Qian ,  Joe Murphy-Boesch ,  Alan Koretsky ,  Stephen John Dodd

Inventor： Chunqi Qian ,  Joe Murphy-Boesch ,  Alan Koretsky ,  Stephen John Dodd

IPC: G01R33/36

CPC classification number: G01R33/3692 ,  A61B5/00 ,  G01R33/285 ,  G01R33/3621

Abstract: An implantable parametric circuit enables local signal amplification and wireless transmission of RF signals in connection with magnetic resonance imaging systems. The parametric circuit detects RF signal detected during magnetic resonance imaging procedure, amplifies the detected RF signal, and transmits the amplified RF signal in a wireless manner to an external pick-up coil. The parametric amplifier is also configured to use another RF signal generated by an external source as the primary power source. As a result, implanted or catheter coils could be used as a wireless signal transducer without the need for a battery or a power connection.

Abstract translation: 可植入参数电路可实现与磁共振成像系统相关的RF信号的本地信号放大和无线传输。 参数电路检测在磁共振成像过程中检测到的RF信号，放大检测到的RF信号，并将放大的RF信号以无线方式发送到外部拾取线圈。 参数放大器还被配置为使用由外部源产生的另一RF信号作为主电源。 因此，植入式或导管线圈可以用作无线信号传感器，而不需要电池或电源连接。

公开(公告)号：US09864026B2

公开(公告)日：2018-01-09

申请号：US14008133

申请日：2012-03-29

Applicant: Chunqi Qian ,  Joe Murphy-Boesch ,  Alan Koretsky ,  Stephen John Dodd

Inventor： Chunqi Qian ,  Joe Murphy-Boesch ,  Alan Koretsky ,  Stephen John Dodd

IPC: A61B5/00 ,  G01R33/36 ,  G01R33/28

CPC classification number: G01R33/3692 ,  A61B5/00 ,  G01R33/285 ,  G01R33/3621

Abstract: An implantable parametric circuit enables local signal amplification and wireless transmission of RF signals in connection with magnetic resonance imaging systems. The parametric circuit detects RF signal detected during magnetic resonance imaging procedure, amplifies the detected RF signal, and transmits the amplified RF signal in a wireless manner to an external pick-up coil. The parametric amplifier is also configured to use another RF signal generated by an external source as the primary power source. As a result, implanted or catheter coils could be used as a wireless signal transducer without the need for a battery or a power connection.