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公开(公告)号：US5660849A
公开(公告)日：1997-08-26
申请号：US294754
申请日：1994-08-23
申请人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
发明人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
IPC分类号： A61C8/00 , A61C19/06 , A61F2/02 , A61F2/08 , A61F2/28 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K47/34 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/00 , B29C41/08 , B29C41/12 , B29C67/00 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B29K2995/0056 , B29K2995/006
摘要： The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
摘要翻译： 本发明涉及具有由外囊和液体含量制成的两部分结构的可生物降解的植入物前体。 植入物前体由可生物降解的水凝性热塑性聚合物和水混溶性有机溶剂组成。 当施用到动物的植入部位时，植入物前体将通过将有机溶剂消散到周围的组织流体和聚合物的凝结而原位固化成固体，微孔基质。 本发明还包括制备植入物前体，用于形成前体的装置和包含该装置的试剂盒的方法。 还提供了使用植入物前体来治疗动物中的组织缺陷的方法，例如用于增强细胞生长和组织再生，伤口和器官修复，神经再生，软和硬组织再生等，用于递送 生物活性物质到组织或器官，以及其他类似疗法。
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公开(公告)号：US06395293B2
公开(公告)日：2002-05-28
申请号：US09520735
申请日：2000-03-08
申请人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
发明人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
IPC分类号： A61F200
CPC分类号： A61K9/0024 , A61K9/0063 , A61K9/1647 , A61K31/74 , A61K33/42 , A61K47/34 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B29C41/08 , B29C41/12 , B29C67/06 , B29K2995/0056 , B29K2995/006 , C08L67/04
摘要： The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
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公开(公告)号：US6071530A
公开(公告)日：2000-06-06
申请号：US883260
申请日：1997-06-26
申请人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
发明人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
IPC分类号： A61C8/00 , A61C19/06 , A61F2/02 , A61F2/08 , A61F2/28 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K47/34 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/00 , B29C41/08 , B29C41/12 , B29C67/00 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B29K2995/0056 , B29K2995/006
摘要： The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
摘要翻译： 本发明涉及具有由外囊和液体含量制成的两部分结构的可生物降解的植入物前体。 植入物前体由可生物降解的水凝性热塑性聚合物和水混溶性有机溶剂组成。 当施用到动物的植入部位时，植入物前体将通过将有机溶剂消散到周围的组织流体和聚合物的凝结而原位固化成固体，微孔基质。 本发明还包括制备植入物前体，用于形成前体的装置和包含该装置的试剂盒的方法。 还提供了使用植入物前体来治疗动物中的组织缺陷的方法，例如用于增强细胞生长和组织再生，伤口和器官修复，神经再生，软和硬组织再生等，用于递送 生物活性物质到组织或器官，以及其他类似疗法。
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公开(公告)号：US5487897A
公开(公告)日：1996-01-30
申请号：US127642
申请日：1993-09-28
申请人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
发明人： Alan M. Polson , Deryl D. Swanbom , Richard L. Dunn , Charles P. Cox , Richard L. Norton , Bryan K. Lowe , Kenneth S. Peterson
IPC分类号： A61C8/00 , A61C19/06 , A61F2/02 , A61F2/08 , A61F2/28 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K47/34 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/00 , B29C41/08 , B29C41/12 , B29C67/00 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , B29K2995/0056 , B29K2995/006
摘要： The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.
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