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公开(公告)号：US20120142008A1
公开(公告)日：2012-06-07
申请号：US13347544
申请日：2012-01-10
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
IPC分类号： C12Q1/02 , C12Q1/68 , G01N33/566 , C12N5/10
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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公开(公告)号：US20100317049A1
公开(公告)日：2010-12-16
申请号：US12843536
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
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3.发明授权Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US08105828B2
公开(公告)日：2012-01-31
申请号：US12843536
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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4.发明申请Stable Cell Lines and Methods for Evaluating Gastrointestinal Absorption of Chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US20100311082A1
公开(公告)日：2010-12-09
申请号：US12843706
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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5.发明授权Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US07795019B2
公开(公告)日：2010-09-14
申请号：US11938065
申请日：2007-11-09
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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公开(公告)号：US08110398B2
公开(公告)日：2012-02-07
申请号：US12843706
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
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