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1.发明授权Methods and compositions for targeting agents into and across the blood-barrier and other endothelial cell microvascular barriers 有权靶向药物穿过血管屏障和其他内皮细胞微血管屏障的方法和组合物公开(公告)号：US08026209B2
公开(公告)日：2011-09-27
申请号：US10544991
申请日：2004-02-10
CPC分类号： C07K14/34 , A01K2217/05 , A61K38/00 , A61K47/6415 , A61K47/6911 , C07K14/47 , C07K14/52 , C07K2319/035 , Y10S424/832 , Y10S977/714 , Y10S977/773 , Y10S977/801 , Y10S977/808
摘要： The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.
摘要翻译： 本发明涉及由此编码的核酸和多肽，其表达在脑微血管内皮细胞中受到早期动态炎症诱发的血脑屏障功能变化的调节。 这些多肽在本文中称为脂多糖敏感（LPSS）多肽。 这些核酸和多肽可用于在需要这种生物效应的哺乳动物中控制血脑屏障性能的方法中。 这包括诊断和治疗血脑/视网膜屏障，脑（包括眼睛）疾病以及外周血管疾病的干扰。 另外，本发明涉及抗LPSS多肽抗体或配体作为诊断探针的用途，作为血脑屏障靶向剂或作为治疗剂，以及使用LPSS多肽的表达，活化或生物活性的配体或调节剂作为 诊断探针，治疗剂或药物递送增强剂。
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2.发明申请公开(公告)号：US20080213179A1
公开(公告)日：2008-09-04
申请号：US10544991
申请日：2004-02-10
IPC分类号： A61K49/00 , A61K38/00 , A61K39/395 , A61K48/00 , G01N33/53 , A61K31/70 , A61K9/127 , A61K9/50
CPC分类号： C07K14/34 , A01K2217/05 , A61K38/00 , A61K47/6415 , A61K47/6911 , C07K14/47 , C07K14/52 , C07K2319/035 , Y10S424/832 , Y10S977/714 , Y10S977/773 , Y10S977/801 , Y10S977/808
摘要： The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.
摘要翻译： 本发明涉及由此编码的核酸和多肽，其表达在脑微血管内皮细胞中受到早期动态炎症诱发的血脑屏障功能变化的调节。 这些多肽在本文中称为脂多糖敏感（LPSS）多肽。 这些核酸和多肽可用于在需要这种生物效应的哺乳动物中控制血脑屏障性能的方法中。 这包括诊断和治疗血脑/视网膜屏障，脑（包括眼睛）疾病以及外周血管疾病的干扰。 另外，本发明涉及抗LPSS多肽抗体或配体作为诊断探针的用途，作为血脑屏障靶向剂或作为治疗剂，以及使用LPSS多肽的表达，活化或生物活性的配体或调节剂作为 诊断探针，治疗剂或药物递送增强剂。
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3.发明申请METHODS AND COMPOSITIONS FOR TARGETING AGENTS INTO AND ACROSS THE BLOOD-BRAIN BARRIER AND OTHER ENDOTHELIAL CELL MICROVASCULAR BARRIERS 有权用于将药剂引入和穿过血脑屏障和其他内皮细胞微血管阻滞剂的方法和组合物公开(公告)号：US20110274749A1
公开(公告)日：2011-11-10
申请号：US13188458
申请日：2011-07-21
IPC分类号： A61K9/127 , A61K31/727 , A61P25/18 , A61P25/00 , A61P25/08 , A61P25/20 , A61P27/02 , A61P25/28 , A61K38/00 , A61P25/06 , B82Y5/00
CPC分类号： C07K14/34 , A01K2217/05 , A61K38/00 , A61K47/6415 , A61K47/6911 , C07K14/47 , C07K14/52 , C07K2319/035 , Y10S424/832 , Y10S977/714 , Y10S977/773 , Y10S977/801 , Y10S977/808
摘要： The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain bather functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain bather properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.
摘要翻译： 本发明涉及由此编码的核酸和多肽，其表达在脑微血管内皮细胞中被调节，其经历早期动态炎症诱发的血脑屏障功能变化。 这些多肽被称为脂多糖敏感（LPSS）多肽。 这些核酸和多肽可用于控制需要这种生物效应的哺乳动物中的血脑沐浴物质的方法。 这包括诊断和治疗血脑/视网膜屏障，脑（包括眼睛）疾病以及外周血管疾病的干扰。 另外，本发明涉及抗LPSS多肽抗体或配体作为诊断探针的用途，作为血脑屏障靶向剂或作为治疗剂，以及使用LPSS多肽的表达，活化或生物活性的配体或调节剂作为 诊断探针，治疗剂或药物递送增强剂。
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