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61 条记录 (耗时 0.037 秒)

    Differentially Expressed Nucleic Acids in the Blood-Brain Barrier Under Inflammatory Conditions
    3.
    发明申请
    Differentially Expressed Nucleic Acids in the Blood-Brain Barrier Under Inflammatory Conditions 有权
    炎症条件下血脑屏障差异表达的核酸

    公开(公告)号：US20080213179A1

    公开(公告)日：2008-09-04

    申请号：US10544991

    申请日：2004-02-10

    申请人： Pieter Jaap Gaillard ,  Albertus Gerrit De Boer ,  Arjen Brink

    发明人： Pieter Jaap Gaillard ,  Albertus Gerrit De Boer ,  Arjen Brink

    IPC分类号： A61K49/00 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  G01N33/53 ,  A61K31/70 ,  A61K9/127 ,  A61K9/50

    CPC分类号： C07K14/34 ,  A01K2217/05 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/6911 ,  C07K14/47 ,  C07K14/52 ,  C07K2319/035 ,  Y10S424/832 ,  Y10S977/714 ,  Y10S977/773 ,  Y10S977/801 ,  Y10S977/808

    摘要： The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced changes in blood-brain barrier functionality. Such polypeptides are referred to as lipopolysaccharide-sensitive (LPSS) polypeptides herein. These nucleic acids and polypeptides may be useful in methods for controlling blood-brain barrier properties in mammals in need of such biological effects. This includes the diagnosis and treatment of disturbances in the blood-brain/retina barrier, brain (including the eye) disorders, as well as peripheral vascular disorders. Additionally, the invention relates to the use of anti-LPSS polypeptide antibodies or ligands as diagnostic probes, as blood-brain barrier targeting agents or as therapeutic agents as well as the use of ligands or modulators of expression, activation or bioactivity of LPSS polypeptides as diagnostic probes, therapeutic agents or drug delivery enhancers.

    摘要翻译： 本发明涉及由此编码的核酸和多肽，其表达在脑微血管内皮细胞中受到早期动态炎症诱发的血脑屏障功能变化的调节。 这些多肽在本文中称为脂多糖敏感（LPSS）多肽。 这些核酸和多肽可用于在需要这种生物效应的哺乳动物中控制血脑屏障性能的方法中。 这包括诊断和治疗血脑/视网膜屏障，脑（包括眼睛）疾病以及外周血管疾病的干扰。 另外，本发明涉及抗LPSS多肽抗体或配体作为诊断探针的用途，作为血脑屏障靶向剂或作为治疗剂，以及使用LPSS多肽的表达，活化或生物活性的配体或调节剂作为 诊断探针，治疗剂或药物递送增强剂。

    Molecules that home to various selected organs or tissues
    8.
    发明申请
    Molecules that home to various selected organs or tissues 失效

    公开(公告)号：US20050074812A1

    公开(公告)日：2005-04-07

    申请号：US10607595

    申请日：2003-06-27

    申请人： Erkki Ruoslahti ,  Renata Pasqualini

    发明人： Erkki Ruoslahti ,  Renata Pasqualini

    IPC分类号： A61K31/195 ,  A61K38/00 ,  A61K47/48 ,  C07K7/06 ,  C07K7/08 ,  G01N33/53 ,  A61K38/08 ,  A61K38/10

    CPC分类号： C07K7/06 ,  A61K31/195 ,  A61K38/00 ,  A61K47/6425 ,  C07K7/08 ,  Y10S977/808 ,  Y10S977/911 ,  Y10S977/912

    摘要： The present invention provides molecules that selectively home to various normal organs or tissues, including to lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut; and provides molecules that selectively home to tumor bearing organs or tissues, including to pancreas bearing a pancreatic tumor or to lung bearing a lung tumor. The invention also provides conjugates, comprising an organ or tissue homing molecule linked to a moiety. Such a moiety can be, for example, a therapeutic agent or a detectable agent. In addition, the invention provides methods of using an organ homing molecule of the invention to identify a particular organ or tissue by contacting the organ or tissue with a molecule of the invention. The invention also provides methods to diagnose or treat a pathology of the lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut by administering to a subject having or suspected of having a pathology a molecule that homes to the selected organ or tissue. The invention further provides methods of identifying a target molecule in lung, pancreas, skin, retina, prostate, ovary, lymph node, adrenal gland, liver or gut.