公开(公告)号：US20070048855A1

公开(公告)日：2007-03-01

申请号：US11230374

申请日：2005-09-19

申请人： Alejandra Gamez ,  Lin Wang ,  Woomi Kim ,  Mary Straub ,  Marianne Patch ,  Emil Kakkis ,  Dan Oppenheimer ,  Paul Fitzpatrick ,  Robert Heft ,  Raymond Stevens

发明人： Alejandra Gamez ,  Lin Wang ,  Woomi Kim ,  Mary Straub ,  Marianne Patch ,  Emil Kakkis ,  Dan Oppenheimer ,  Paul Fitzpatrick ,  Robert Heft ,  Raymond Stevens

IPC分类号： C12N9/88 ,  G06F19/00

CPC分类号： C12N9/88 ,  C07K2299/00 ,  Y02A90/26

摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.

摘要翻译： 本发明涉及蛋白质苯丙氨酸氨裂解酶的用途，以及所述蛋白质的生物活性衍生物用于预防或治疗与人或动物体内苯丙氨酸不平衡有关的疾病。 更具体地说，本发明涉及上述分子用于预防或治疗体内苯丙氨酸失衡的治疗用途。 本发明还涉及包含药物活性量的上述治疗分子以及使用所述治疗组合物的治疗方法的治疗组合物。 最后，本发明涉及用于选择所述蛋白质的更多治疗上有效的变体以及所选择的变体本身的方法。

公开(公告)号：US07553653B2

公开(公告)日：2009-06-30

申请号：US11230374

申请日：2005-09-19

申请人： Emilio Kakkis ,  Daniel Oppenheimer ,  Paul Fitzpatrick ,  Robert Heft ,  Alejandra Gamez ,  Lin Wang ,  Woomi Kim ,  Mary Straub ,  Marianne Patch ,  Raymond C. Stevens

发明人： Emilio Kakkis ,  Daniel Oppenheimer ,  Paul Fitzpatrick ,  Robert Heft ,  Alejandra Gamez ,  Lin Wang ,  Woomi Kim ,  Mary Straub ,  Marianne Patch ,  Raymond C. Stevens

IPC分类号： C12N9/88

CPC分类号： C12N9/88 ,  C07K2299/00 ,  Y02A90/26

摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.

摘要翻译： 本发明涉及蛋白质苯丙氨酸氨裂解酶的用途，以及所述蛋白质的生物活性衍生物用于预防或治疗与人或动物体内苯丙氨酸不平衡有关的疾病。 更具体地说，本发明涉及上述分子用于预防或治疗体内苯丙氨酸失衡的治疗用途。 本发明还涉及包含药物活性量的上述治疗分子以及使用所述治疗组合物的治疗方法的治疗组合物。 最后，本发明涉及用于选择所述蛋白质的更多治疗上有效的变体以及所选择的变体本身的方法。