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1.发明申请公开(公告)号：US20070048855A1
公开(公告)日：2007-03-01
申请号：US11230374
申请日：2005-09-19
申请人： Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Emil Kakkis , Dan Oppenheimer , Paul Fitzpatrick , Robert Heft , Raymond Stevens
发明人： Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Emil Kakkis , Dan Oppenheimer , Paul Fitzpatrick , Robert Heft , Raymond Stevens
CPC分类号： C12N9/88 , C07K2299/00 , Y02A90/26
摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
摘要翻译： 本发明涉及蛋白质苯丙氨酸氨裂解酶的用途，以及所述蛋白质的生物活性衍生物用于预防或治疗与人或动物体内苯丙氨酸不平衡有关的疾病。 更具体地说，本发明涉及上述分子用于预防或治疗体内苯丙氨酸失衡的治疗用途。 本发明还涉及包含药物活性量的上述治疗分子以及使用所述治疗组合物的治疗方法的治疗组合物。 最后，本发明涉及用于选择所述蛋白质的更多治疗上有效的变体以及所选择的变体本身的方法。
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2.发明授权公开(公告)号：US07553653B2
公开(公告)日：2009-06-30
申请号：US11230374
申请日：2005-09-19
申请人： Emilio Kakkis , Daniel Oppenheimer , Paul Fitzpatrick , Robert Heft , Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Raymond C. Stevens
发明人： Emilio Kakkis , Daniel Oppenheimer , Paul Fitzpatrick , Robert Heft , Alejandra Gamez , Lin Wang , Woomi Kim , Mary Straub , Marianne Patch , Raymond C. Stevens
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C07K2299/00 , Y02A90/26
摘要： The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the above-cited molecules for preventing or treating a phenylalanine imbalance in vivo. This invention also deals with therapeutic compositions comprising a pharmaceutically active amount of the above-described therapeutic molecules as well as with therapeutic methods using the said therapeutic compositions. Finally, the present invention relates to processes for selecting more therapeutically-effective variants of said protein as well as to the selected variants themselves.
摘要翻译： 本发明涉及蛋白质苯丙氨酸氨裂解酶的用途，以及所述蛋白质的生物活性衍生物用于预防或治疗与人或动物体内苯丙氨酸不平衡有关的疾病。 更具体地说，本发明涉及上述分子用于预防或治疗体内苯丙氨酸失衡的治疗用途。 本发明还涉及包含药物活性量的上述治疗分子以及使用所述治疗组合物的治疗方法的治疗组合物。 最后，本发明涉及用于选择所述蛋白质的更多治疗上有效的变体以及所选择的变体本身的方法。
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3.发明申请Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof 有权原核苯丙氨酸氨裂解酶的组合物及其组合物的使用方法公开(公告)号：US20080008695A1
公开(公告)日：2008-01-10
申请号：US11807227
申请日：2007-05-25
申请人： Michel Vellard , Paul Fitzpatrick , Emil Kakkis , Daniel Wendt
发明人： Michel Vellard , Paul Fitzpatrick , Emil Kakkis , Daniel Wendt
摘要： The present invention is directed to phenylalanine ammonia-lyase (PAL) produced by prokaryotes, wherein such prokaryotic PAL wherein the PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention thus provides compositions of bacterial PAL and biologically active fragments, mutants, variants and analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic and industrial purposes.
摘要翻译： 本发明涉及由原核生物产生的苯丙氨酸氨裂解酶（PAL），其中与野生型PAL相比，PAL变体具有更高的苯丙氨酸转化活性和/或免疫原性降低的原核PAL。 因此，本发明提供了细菌PAL和生物活性片段，突变体，变体和类似物的组合物，以及用于治疗和工业目的的这些组合物的生产，纯化和使用的方法。
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公开(公告)号：US20060040348A1
公开(公告)日：2006-02-23
申请号：US10722371
申请日：2003-11-24
申请人： Minmin Qin , Wai-Pan Chan , Lin Chen , Paul Fitzpatrick , John Henstrand , Dan Wendt , Gary Zecherle , Christopher Starr , Emil Kakkis
发明人： Minmin Qin , Wai-Pan Chan , Lin Chen , Paul Fitzpatrick , John Henstrand , Dan Wendt , Gary Zecherle , Christopher Starr , Emil Kakkis
CPC分类号： C12N9/24 , A61K38/00 , C12Y302/01076
摘要： The present invention provides a recombinant human α-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99%. The present invention further provides large-scale methods to produce and purify commercial grade recombinant human α-L-iduronidase enzyme thereof.
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公开(公告)号：US4291504A
公开(公告)日：1981-09-29
申请号：US126922
申请日：1980-03-03
CPC分类号： B24B33/085 , B24B33/06
摘要： A method and apparatus for gaging the cross-sectional bore diameter generated by an abrading type finishing tool in an abrading machine. The tool and plug gage are mechanically mounted to the same spindle with the plug sized to a predetermined diameter and mounted behind the machining element. The plug gage is indexed to enter the bore being machined at predetermined cycles to determine if an undersize condition of the tool exists. Failure of the plug gage to enter the bore would indicate an undersize condition of the tool and upon the gage entering the bore it would indicate a correct tool size. The invention has further apparatus for shutting down the machine in the event an undersize condition is determined.
摘要翻译： 一种用于测量研磨机中的研磨型精加工产生的横截面孔径的方法和装置。 工具和插头量规机械地安装到相同的主轴上，插头的尺寸达到预定的直径并安装在加工元件的后面。 插塞规被索引以进入以预定周期加工的孔，以确定工具是否存在尺寸过小的状况。 插塞规进入孔的故障将表示工具的尺寸过小，并且在量具进入孔时，它将指示正确的刀具尺寸。 本发明还具有在确定尺寸过小的情况下关闭机器的另外的装置。
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公开(公告)号：US4683743A
公开(公告)日：1987-08-04
申请号：US645977
申请日：1984-08-31
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
CPC分类号： B21H5/027
摘要： An apparatus and method are provided for roll sizing the periphery of cylindrical workpieces to finish and size the workpiece to a close tolerance diameter. The method and apparatus can also be used to prefinish and presize cylindrical workpieces in preparation for subsequent forming of spline teeth or gear teeth and the like on the workpiece periphery.
摘要翻译： 提供了一种装置和方法，用于对圆柱形工件的周边进行辊尺寸以使工件完成并将其尺寸设定为紧公差直径。 该方法和装置也可用于预精炼和预制圆柱形工件，以准备随后在工件周边上形成花键齿或齿轮齿等。
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7.发明申请NOVEL Bak BINDING PROTEIN, DNA ENCODING THE PROTEIN, AND METHODS OF USE THEREOF 有权新蛋白结合蛋白，编码蛋白的DNA及其使用方法公开(公告)号：US20070099215A1
公开(公告)日：2007-05-03
申请号：US11539859
申请日：2006-10-09
申请人： Michael Kiefer , Paul Fitzpatrick , Helen Gibson , Philip Barr
发明人： Michael Kiefer , Paul Fitzpatrick , Helen Gibson , Philip Barr
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K2319/00 , G01N2333/47 , G01N2500/02 , G01N2510/00
摘要： The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to BBP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BBP with a Bak protein. The invention further provides methods for detecting the presence of bbp or BBP in a biological sample, and further provides methods for modulating the levels of BBP in a cell. This invention additionally encompasses novel peptides, designated the “BBP Binding Domains” and the respective nucleotides, designated “bbpbd-1” and “bbpbd-2” which are involved in the interaction between Bak and BBP.
摘要翻译： 本发明提供编码Bak结合蛋白（BBP）的多核苷酸序列（bbp）及其与Bak结合的片段。 本发明还提供了结合Bak的BBP。 本发明还提供含有编码BBP的多核苷酸的重组宿主细胞。 本发明还提供了特异性结合BBP的抗体。 本发明还提供了用于检测诸如改变BBP与Bak蛋白的结合的药物的药物的方法。 本发明还提供了用于检测生物样品中bbp或BBP的存在的方法，并且还提供了调节细胞中BBP水平的方法。 本发明另外包括称为“BBP结合域”的新肽，以及涉及Bak和BBP之间的相互作用的“bbpbd-1”和“bbpbd-2”的相应核苷酸。
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8.发明申请Precursor N-acetylgalactosamine-4 sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme 审中-公开前体N-乙酰半乳糖胺-4-硫酸酯酶，使用所述酶的处理方法和生产和纯化所述酶的方法公开(公告)号：US20050287133A1
公开(公告)日：2005-12-29
申请号：US11135264
申请日：2005-05-23
申请人： Minmin Qin , Gary Zecherle , Wai-Pan Chan , Paul Fitzpatrick , Stuart Swiedler , John Henstrand , Dan Wendt , Lin Chen , Christopher Starr
发明人： Minmin Qin , Gary Zecherle , Wai-Pan Chan , Paul Fitzpatrick , Stuart Swiedler , John Henstrand , Dan Wendt , Lin Chen , Christopher Starr
CPC分类号： B01D15/327 , A61K38/00 , A61K48/00 , B01D15/3804 , B01D15/3828 , C12N9/16 , C12Y301/06012
摘要： The present invention provides a highly purified recombinant, human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
摘要翻译： 本发明提供高度纯化的重组人前体N-乙酰半乳糖胺-4-硫酸酯酶及其生物活性突变体，其片段和类似物以及包含高度纯化的重组人前体N-乙酰半乳糖胺-4-硫酸酯酶的药物制剂。 本发明还提供了用于治疗全部或部分由包括MPS VI在内的人N-乙酰半乳糖胺-4-硫酸酯酶缺陷引起的疾病的方法，以及用于将重组前体酶生产和纯化成高度纯化形式的方法。
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公开(公告)号：US4680894A
公开(公告)日：1987-07-21
申请号：US516624
申请日：1983-07-25
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
CPC分类号： B24B33/02
摘要： Thin wall, torque sensitive pinion gears, sun gears or other such workparts are driven in rotation in a fixture during honing of the internal diameter to minimize out-of-roundness. The fixture for honing multiple workparts at a time includes a workpart driving means having multiple workpart driving gears each meshed with a respective one of the workparts. Each workpart driving gear is mounted on a hollow rotatable bushing arranged end-to-end with respect to adjacent bushings and dog-bone shaped driver members interconnect and are drivingly received in adjacent bushings. Means is connected to one of the dog-bone shaped members to rotate same and thereby cause the workpart driver gears to rotate the workparts in unison during honing.
摘要翻译： 珩磨内径时，薄壁，扭矩敏感小齿轮，太阳齿轮或其他这样的工件在固定装置中旋转地被驱动以最小化不圆度。 一次用于珩磨多个工件的夹具包括具有多个工件驱动齿轮的工件驱动装置，每个工件驱动装置与相应的一个工件啮合。 每个工件驱动齿轮安装在相对于相邻衬套端对端布置的中空可旋转衬套上，并且狗骨形的驱动器构件互连并且被驱动地容纳在相邻衬套中。 装置连接到其中一个狗骨形构件以使其旋转，从而使得工件驱动齿轮在珩磨期间一致地旋转工件。
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公开(公告)号：US4488418A
公开(公告)日：1984-12-18
申请号：US356986
申请日：1982-03-11
申请人： Paul Fitzpatrick
发明人： Paul Fitzpatrick
CPC分类号： B21H5/027
摘要： An apparatus and method are provided for roll sizing the periphery of cylindrical workpieces to finish and size the workpiece to a close tolerance diameter. The method and apparatus can also be used to prefinish and presize cylindrical workpieces in preparation for subsequent forming of spline teeth or gear teeth and the like on the workpiece periphery.
摘要翻译： 提供了一种装置和方法，用于对圆柱形工件的周边进行辊尺寸以使工件完成并将其尺寸设定为紧公差直径。 该方法和装置也可用于预精炼和预制圆柱形工件，以准备随后在工件周边上形成花键齿或齿轮齿等。
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