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公开(公告)号：US20130331369A1
公开(公告)日：2013-12-12
申请号：US13962689
申请日：2013-08-08
申请人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
发明人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
IPC分类号： C07D471/10 , A61K31/55 , C07D487/10 , A61K31/407 , A61K31/435 , A61K45/06
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译： 本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。
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2.发明申请公开(公告)号：US20120302540A1
公开(公告)日：2012-11-29
申请号：US13479596
申请日：2012-05-24
申请人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
发明人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
IPC分类号： A61K31/438 , A61P1/00 , A61K31/407 , A61K31/55 , C07D471/10 , C07D487/10
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译： 本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。
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公开(公告)号：US20090023707A1
公开(公告)日：2009-01-22
申请号：US12173255
申请日：2008-07-15
IPC分类号： A61K31/55 , C07D235/16 , A61K31/4184 , C07K14/705 , A61P25/18 , A61P25/28 , A61P25/16 , A61K31/5377 , C07D413/14
CPC分类号： C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
摘要翻译： 本发明提供式I化合物及其用于治疗与组胺-3受体相关或受组胺3受体影响的中枢神经系统病症的用途。
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4.发明授权Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation 有权三环吡啶衍生物，含有此类化合物的药物，其用途及其制备方法公开(公告)号：US08703793B2
公开(公告)日：2014-04-22
申请号：US12920722
申请日：2009-03-02
申请人： Holger Wagner , Daniela Berta , Riccardo Giovannini , Alessandro Mazzacani , Ruediger Streicher , Klaus Fuchs
发明人： Holger Wagner , Daniela Berta , Riccardo Giovannini , Alessandro Mazzacani , Ruediger Streicher , Klaus Fuchs
IPC分类号： A61K31/4355 , C07D491/048
CPC分类号： C07D493/04 , C07D493/10
摘要： Compounds of formula (I) wherein the groups R1 to R8 have the meanings indicated in the description, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof have valuable pharmacological properties, which make them useful for the treatment of cardiovascular and related disorders.
摘要翻译： 式（I）的化合物，其中基团R 1至R 8具有说明书中所述的含义，互变异构体，立体异构体，其混合物及其盐具有有价值的药理学性质，使其可用于治疗心血管和相关疾病 。
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公开(公告)号：US08546416B2
公开(公告)日：2013-10-01
申请号：US13479596
申请日：2012-05-24
申请人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
发明人： Ameet Vijay Ambarkhane , Gurdip Bhalay , Martin Beckett , James Dale , Ahmed Hamadi , Alessandro Mazzacani , Jeffrey McKenna , Christopher Thomson
IPC分类号： C07D211/00 , C07D213/00 , C07D215/00 , C07D219/00 , C07D221/00 , C07D217/00
CPC分类号： C07D471/10 , A61K31/407 , A61K31/435 , A61K31/55 , A61K45/06 , C07D487/10
摘要： The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
摘要翻译： 本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。
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6.发明申请Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation 有权三环吡啶衍生物，含有此类化合物的药物，其用途及其制备方法公开(公告)号：US20110021550A1
公开(公告)日：2011-01-27
申请号：US12920722
申请日：2009-03-02
申请人： Holger Wagner , Daniela Berta , Riccardo Giovannini , Alessandro Mazzacani , Ruediger Streicher , Klaus Fuchs
发明人： Holger Wagner , Daniela Berta , Riccardo Giovannini , Alessandro Mazzacani , Ruediger Streicher , Klaus Fuchs
IPC分类号： A61K31/438 , C07D491/04 , C07D491/10 , A61K31/4355 , A61P9/10
CPC分类号： C07D493/04 , C07D493/10
摘要： Compounds of formula (I) wherein the groups R1 to R8 have the meanings indicated in the description, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof have valuable pharmacological properties, which make them useful for the treatment of cardiovascular and related disorders.
摘要翻译： 式（I）化合物，其中基团R 1至R 8具有说明书中所述的含义，互变异构体，立体异构体，其混合物及其盐具有有价值的药理学性质，使其可用于治疗心血管和相关疾病 。
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公开(公告)号：US07803825B2
公开(公告)日：2010-09-28
申请号：US12173255
申请日：2008-07-15
IPC分类号： A61K31/42
CPC分类号： C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula Ia: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
摘要翻译： 本发明提供式Ia化合物及其用于治疗与组胺-3受体相关或受组胺3受体影响的中枢神经系统疾病的用途。
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