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15 条记录 (耗时 0.039 秒)

    Compounds useful for the treatment of cancer, compositions thereof and methods therewith
    6.
    发明授权
    Compounds useful for the treatment of cancer, compositions thereof and methods therewith 失效
    可用于治疗癌症的化合物，其组合物和方法

    公开(公告)号：US07037936B2

    公开(公告)日：2006-05-02

    申请号：US10463009

    申请日：2003-06-16

    申请人： Jeffrey McKenna ,  Frank Mercurio ,  Veronique Plantevin ,  Weilin Xie ,  Michele Pagano

    发明人： Jeffrey McKenna ,  Frank Mercurio ,  Veronique Plantevin ,  Weilin Xie ,  Michele Pagano

    IPC分类号： A61K31/35

    CPC分类号： A61K31/351 ,  A61K31/135 ,  A61K31/4025

    摘要： The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular disease, an effect of aging or an infectious disease comprising administering an effective amount of a Compound of the Invention. The invention further relates to the use of a Compound of the Invention as a preservative of a cell, blood, tissue or an organ or as an agent to modulate stem cells.

    摘要翻译： 本发明一般涉及可用于调节连接酶活性的化合物和组合物。 本发明还涉及本发明的化合物，其组合物，以及用于治疗或预防癌症，肿瘤性疾病，急性或慢性肾功能衰竭，炎症性疾病，免疫疾病，心血管疾病，衰老或感染性的影响的方法 疾病，包括施用有效量的本发明化合物。 本发明还涉及本发明的化合物作为细胞，血液，组织或器官的防腐剂或作为调节干细胞的药剂的用途。

    Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith
    8.
    发明申请
    Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith 审中-公开
    TNFalpha，PDE4和B-RAF的抑制剂，其组合物及其使用方法

    公开(公告)号：US20080004271A1

    公开(公告)日：2008-01-03

    申请号：US11654344

    申请日：2007-01-16

    申请人： Jeffrey McKenna ,  Patrick Papa ,  Steven Sakata ,  Paul Erdman ,  Garrick Packard

    发明人： Jeffrey McKenna ,  Patrick Papa ,  Steven Sakata ,  Paul Erdman ,  Garrick Packard

    IPC分类号： A61K31/519 ,  A61K31/5377 ,  A61P35/00 ,  C07D413/14 ,  C07D495/04 ,  C12N5/00

    CPC分类号： C07D495/04

    摘要： Provided herein are compounds having TNFα and/or PDE4 and/or B-RAF inhibitory activity, and compositions thereof. In particular, provided herein are compounds of the formula I: and pharmaceutically acceptable salts, solvates, hydrates, clathrates, stereoisomers, polymorphs and prodrugs thereof, wherein Ar, R1, R2, R3, R4, n and Z are as described herein. Further provided herein are methods for treating or preventing various diseases and disorders by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors. In particular, provided herein are methods for preventing or treating cancer, inflammatory disorders, cognition and memory disorders and autoimmune disorders, or one or more symptoms thereof by administering to a patient one or more TNFα and/or PDE4 and/or B-RAF inhibitors.

    摘要翻译： 本文提供具有TNFα和/或PDE4和/或B-RAF抑制活性的化合物及其组合物。 特别地，本文提供了式I的化合物及其药学上可接受的盐，溶剂合物，水合物，包合物，立体异构体，多晶型物和前药，其中Ar，R 1，R 2， R S，R 3，R 4，n和Z如本文所述。 本文还提供了通过向患者施用一种或多种TNFα和/或PDE4和/或B-RAF抑制剂来治疗或预防各种疾病和病症的方法。 特别地，本文提供了通过向患者施用一种或多种TNFα和/或PDE4和/或B-RAF抑制剂来预防或治疗癌症，炎症性疾病，认知和记忆障碍和自身免疫性疾病或其一种或多种症状的方法 。

    COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH
    9.
    发明申请
    COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH 失效
    用于治疗癌症的组合物及其组合物及其方法

    公开(公告)号：US20060030617A1

    公开(公告)日：2006-02-09

    申请号：US10463009

    申请日：2003-06-16

    申请人： Jeffrey McKenna ,  Frank Mercurio ,  Veronique Plantevin ,  Weilin Xie

    发明人： Jeffrey McKenna ,  Frank Mercurio ,  Veronique Plantevin ,  Weilin Xie

    IPC分类号： A61K31/35 ,  A61K31/277 ,  A61K31/195 ,  A61K31/137

    CPC分类号： A61K31/351 ,  A61K31/135 ,  A61K31/4025

    摘要： The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular disease, an effect of aging or an infectious disease comprising administering an effective amount of a Compound of the Invention. The invention further relates to the use of a Compound of the Invention as a preservative of a cell, blood, tissue or an organ or as an agent to modulate stem cells.

    摘要翻译： 本发明一般涉及可用于调节连接酶活性的化合物和组合物。 本发明还涉及本发明的化合物，其组合物，以及用于治疗或预防癌症，肿瘤性疾病，急性或慢性肾功能衰竭，炎症性疾病，免疫疾病，心血管疾病，衰老或感染性的影响的方法 疾病，包括施用有效量的本发明化合物。 本发明还涉及本发明的化合物作为细胞，血液，组织或器官的防腐剂或作为调节干细胞的药剂的用途。