公开(公告)号：US20240425473A2

公开(公告)日：2024-12-26

申请号：US18263582

申请日：2022-02-01

Applicant: Pinghui FENG ,  Chao ZHANG ,  Jun ZHAO ,  Biancha ESPINOSA ,  Chao QIN ,  Ali SAVAS ,  Youliang RAO ,  Ting-Yu WANG

Inventor： Pinghui FENG ,  Chao ZHANG ,  Jun ZHAO ,  Biancha ESPINOSA ,  Chao QIN ,  Ali SAVAS ,  Youliang RAO ,  Ting-Yu WANG

IPC: C07D333/38 ,  A61K9/00 ,  A61K9/06 ,  A61K9/20 ,  A61K9/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44 ,  A61P31/14 ,  C07C233/65 ,  C07C233/75 ,  C07C233/76 ,  C07D233/88 ,  C07D239/94

Abstract: The invention relates to antiviral compounds, compositions comprising antiviral compounds, and methods of use. In particular, the antiviral compounds are cytidine triphosphate synthetase 1 (CTPS1) inhibitors that are effective in treating and/or preventing viral infection and in particular, SARS-CoV-2 infection and/or COVID-19 disease.