Regulation of integrin surface expression
    1.
    发明授权
    Regulation of integrin surface expression 有权
    整合素表面表达调控

    公开(公告)号:US07928084B2

    公开(公告)日:2011-04-19

    申请号:US12543836

    申请日:2009-08-19

    IPC分类号: A61K31/70 C07H21/04

    摘要: Disclosed are methods and compositions for preventing and treating conditions associated with platelet aggregation, comprising administering a therapeutically effective amount of a composition that modifies the interaction of DNAJC10 with αIIbβ3 in a megakaryocyte, thereby altering the expression of αIIbβ3 on the surface of the megakaryocyte.

    摘要翻译: 公开了用于预防和治疗与血小板聚集有关的病症的方法和组合物,其包括施用治疗有效量的在大细胞中修饰DNAJC10与αIIb和bgr3的相互作用的组合物,从而改变αIIb和bgr3在表面上的表达 巨核细胞。

    Regulation of Integrin Surface Expression
    3.
    发明申请
    Regulation of Integrin Surface Expression 有权
    整合素表达表达调控

    公开(公告)号:US20100048677A1

    公开(公告)日:2010-02-25

    申请号:US12543836

    申请日:2009-08-19

    IPC分类号: A61K31/7105

    摘要: Disclosed are methods and compositions for preventing and treating conditions associated with platelet aggregation, comprising administering a therapeutically effective amount of a composition that modifies the interaction of DNAJC10 with αIIbβ3 in a megakaryocyte, thereby altering the expression of αIIbβ3 on the surface of the megakaryocyte.

    摘要翻译: 公开了用于预防和治疗与血小板聚集有关的病症的方法和组合物,其包括施用治疗有效量的在大细胞中修饰DNAJC10与αIIb和bgr3的相互作用的组合物,从而改变αIIb和bgr3在表面上的表达 巨核细胞。