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1.发明申请SUBSTITUTED PYRROLIDINONE AS INHIBITORS OF HEPATITIS C NS5B POLYMERASE, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE 审中-公开取代的吡咯烷酮作为丙型肝炎病毒C NS5B聚合酶，其药物组合物及其治疗用途的抑制剂公开(公告)号：US20120189579A1
公开(公告)日：2012-07-26
申请号：US13383042
申请日：2010-07-09
IPC分类号： A61K38/21 , A61K31/427 , A61K31/433 , C07D417/14 , A61K31/7056 , A61K31/5377 , A61K31/428 , A61P31/12 , A61P31/14 , A61P31/18 , C07D417/04 , A61K31/4439
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention concerns a substituted pyrrolidinone of the following formula I or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: (I), for the treatment of hepatitis C.
摘要翻译： 本发明涉及下式I的取代吡咯烷酮或其盐，溶剂合物，互变异构体，同位素，对映体，非对映异构体或外消旋混合物：（I），用于治疗丙型肝炎
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![Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them](/abs-image/US/2005/11/08/US06962912B2/abs.jpg.150x150.jpg)
2.发明授权Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them 失效取代的吡唑并[4,3-e]二氮杂，含有它们的药物组合物，用作药物及其制备方法公开(公告)号：US06962912B2
公开(公告)日：2005-11-08
申请号：US10169375
申请日：2000-12-27
IPC分类号： A61K31/5513 , A61K31/5517 , A61P35/00 , C07D231/00 , C07D243/00 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them.
摘要翻译： 本发明涉及以下通式的新型取代吡唑并[4,3-e] - 二氮杂：含有它们的药物组合物，其用作药物用途及其制备方法。
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![Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them](/abs-image/US/2005/06/16/US20050130957A1/abs.jpg.150x150.jpg)
3.发明申请Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them 失效新型取代的吡唑并[4,3-e]二氮杂，含有它们的药物组合物，用作医疗产品和制备它们的方法公开(公告)号：US20050130957A1
公开(公告)日：2005-06-16
申请号：US11050526
申请日：2005-02-02
IPC分类号： A61K31/5513 , A61K31/5517 , A61P35/00 , C07D231/00 , C07D243/00 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them.
摘要翻译： 本发明涉及以下通式的新型取代吡唑并[4,3-e] - 二氮杂：含有它们的药物组合物，其用作药物用途及其制备方法。
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4.发明授权
公开(公告)号：US6111136A
公开(公告)日：2000-08-29
申请号：US101247
申请日：1998-09-04
IPC分类号： C07B61/00 , C07C51/34 , C07C53/21 , C07C303/16 , C07C309/06 , C07C309/00
CPC分类号： C07C303/16 , C07C51/34
摘要： The invention consists of a new method for preparing perfluoroalcanecarboxylic and perfluoroalcanesulfonic acids in which ozone is made to react, in a protic environment, upon a perfluoroalkyl chain comprising at least one oxydizable chemical group.
摘要翻译： PCT No.PCT / FR96 / 02079 Sec。 371日期：1998年9月4日 102（e）1998年9月4日PCT PCT 1996年12月24日PCT公布。 公开号WO97 / 24309 日期1997年7月10日本发明由一种制备全氟羧酸和全氟马烷磺酸的新方法组成，其中使臭氧在质子环境下与包含至少一个可氧化化学基团的全氟烷基链反应。
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5.发明申请1-(6 MEMBERS AZO-HETEROCYCLIC)-PYRROLIN-2-ONE COMPOUNDS AS INHIBITORS OF HEPATITIS C NS5B POLYMERASE, THE PHARAMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE 审中-公开1-（6个成员AZO-杂环） - 吡咯烷-2-酮化合物作为丙型肝炎病毒NS5B聚合酶的抑制剂，其药物组合物及其治疗用途公开(公告)号：US20120128630A1
公开(公告)日：2012-05-24
申请号：US13383120
申请日：2010-07-09
IPC分类号： A61K38/21 , A61K31/501 , A61K31/4439 , C07D413/14 , A61P31/12 , C07D403/14 , C07D401/04 , C07D417/14 , A61P31/18 , C07D405/14 , A61K31/5377 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14
摘要： The present invention concerns a 1-(6 members azo-heterocyclic)-pyrrolin-2-one compound of the following formula I or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C NS5B polymerase.
摘要翻译： 本发明涉及下式I的1-（6成员偶氮 - ）吡咯啉-2-酮化合物或其盐，溶剂合物，互变异构体，同位素，对映异构体，非对映异构体或外消旋混合物：其药物组合物及其 作为丙型肝炎NS5B聚合酶抑制剂的治疗用途。
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![Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them](/abs-image/US/2007/06/19/US07232816B2/abs.jpg.150x150.jpg)
6.发明授权Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them 失效取代的吡唑并[4,3-e]二氮杂，含有它们的药物组合物，用作医药产品和制备它们的方法公开(公告)号：US07232816B2
公开(公告)日：2007-06-19
申请号：US11050526
申请日：2005-02-02
IPC分类号： C07D487/04 , C07D243/00 , C07D231/00 , A61K31/5517
CPC分类号： C07D487/04
摘要： The invention relates to novel substituted pyrazolo[4,3-e]-diazepines of general formula: to pharmaceutical compositions containing them, to their use as medicinal products and to processes for preparing them.
摘要翻译： 本发明涉及以下通式的新型取代吡唑并[4,3-e] - 二氮杂：含有它们的药物组合物，其用作药物用途及其制备方法。
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