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公开(公告)号：US20110177962A1
公开(公告)日：2011-07-21
申请号：US12688193
申请日：2010-01-15
CPC分类号： G01N33/54366 , B01L3/5027 , C12Q1/6816 , G01N33/54393 , C12Q2565/501
摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
摘要翻译： 确定溶液成分的数量的方法包括将第一数量的溶液成分引入到第一测试位置，为所引入的第一数量的溶液成分建立第一结合环境，通过将第一数量的溶液成分结合到第一残留数量的溶液成分 多个溶液成分，为第一剩余数量的溶液组分建立第二结合环境，通过将第二多个溶液组分与第一剩余数量的溶液组分结合而产生第二剩余数量的溶液组分，获得与 绑定的第一多个解决方案组成部分，获得与绑定的第二多个解决方案组成部分相关联的第二信号，以及基于获得的第一信号和获得的第二信号来确定感兴趣的组成部分的第二数量。
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公开(公告)号：US11275084B2
公开(公告)日：2022-03-15
申请号：US12688193
申请日：2010-01-15
IPC分类号： B01L3/00 , G01N33/543 , C12Q1/6816
摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
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公开(公告)号：US20110091870A1
公开(公告)日：2011-04-21
申请号：US12580113
申请日：2009-10-15
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
摘要翻译： 在一个实施方案中检测生物标志物的方法包括鉴定样品中的生物分子类型的数量，将样品暴露于多个测试位点，其中多个测试位点中的测试位点的数目等于或大于所鉴定的 生物分子类型的数量，为多个测试点中的每一个建立相应的测试环境，其中，所述多个测试位置中的每一个的测试环境与所述多个测试位置中的每一个的每个测试位置中的每一个的测试环境不同 获得与所述多个测试点中的每一个相关联的检测信号，以及基于所获得的检测信号来确定所述生物分子类型之一的浓度。
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公开(公告)号：US09927435B2
公开(公告)日：2018-03-27
申请号：US12580113
申请日：2009-10-15
IPC分类号： G01N33/00 , G01N33/543 , G01N29/32 , G01N33/53
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
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