公开(公告)号：US09669049B2

公开(公告)日：2017-06-06

申请号：US13882487

申请日：2011-10-31

申请人： Harry E. Gruber ,  Douglas J. Jolly ,  Derek G. Ostertag ,  Ryan S. Burnett ,  Amy H. Lin ,  Tiffany Huang ,  Joan M. Robbins

发明人： Harry E. Gruber ,  Douglas J. Jolly ,  Derek G. Ostertag ,  Ryan S. Burnett ,  Amy H. Lin ,  Tiffany Huang ,  Joan M. Robbins

IPC分类号： A61K31/56 ,  A61K31/58 ,  A61K31/573 ,  A61K31/713 ,  A61K31/7088 ,  A61K39/21 ,  A61K39/395 ,  C12N15/867 ,  A61K35/768 ,  A61K9/127 ,  A61N5/10

CPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K35/768 ,  A61K39/21 ,  A61K39/3955 ,  A61K39/39558 ,  A61N5/10 ,  C12N15/867 ,  C12N2740/13032 ,  A61K2300/00

摘要： This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

公开(公告)号：US20130323301A1

公开(公告)日：2013-12-05

申请号：US13882487

申请日：2011-10-31

申请人： Harry E. Gruber ,  Douglas J. Jolly ,  Derek G. Ostertag ,  Ryan S. Burnett ,  Amy H. Lin ,  Tiffany Huang ,  Joan M. Robbins

发明人： Harry E. Gruber ,  Douglas J. Jolly ,  Derek G. Ostertag ,  Ryan S. Burnett ,  Amy H. Lin ,  Tiffany Huang ,  Joan M. Robbins

IPC分类号： A61K31/7088 ,  A61K31/573 ,  A61N5/10 ,  A61K9/127 ,  A61K31/713 ,  A61K39/395 ,  A61K31/58

CPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K35/768 ,  A61K39/21 ,  A61K39/3955 ,  A61K39/39558 ,  A61N5/10 ,  C12N15/867 ,  C12N2740/13032 ,  A61K2300/00

摘要： This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

摘要翻译： 本公开涉及用于治疗细胞增殖性疾病的复制有效的病毒载体。 本公开还涉及这种复制感受态病毒载体在正常和患病组织中递送和表达异源核酸的用途以及促进体内和体外对组织的这种递送和表达的方法和组合物。 本公开还涉及用于这些用途的复制有效的逆转录病毒载体，以及促进体内治疗的方法和组合物。