摘要:
Novel compounds of formula I, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; and ii) (2R/S, 3R)-(3-amino-2-hydroxybutyl)phosphinic acid, having affinity to one or more GABAB receptors, their pharmaceutically acceptable salts, solvates and stereoisomers, as well as processes for their preparation, pharmaceutical compositions containing said therapeutically active compounds and the use of said active compounds in therapy.
摘要:
The present invention relates to a device for determining the correct lengths of standardized components of a dental implant system in situ in the oral cavity. The device comprises an elongate gauge body being provided with circumferential dark bands located at predetermined distances from each other and having predetermined widths, the areas between said darker bands having a pronouncedly lighter color, each boundary line between lighter and darker bands corresponding to one specific, standardized component.
摘要:
The present invention relates to a device for determining the correct lengths of standardized components of a dental implant system in situ in the oral cavity. The device comprises an elongate gauge body (1, 2) being provided with circumferential dark bands (10, 18, 19, 20, 21) located at predetermined distances from each other and having predetermined widths, the areas between said darker bands having a pronouncedly lighter colour, each boundary line between lighter and darker bands corresponding to one specific, standardized component.
摘要:
The present invention relates to a screw implant (1) for insertion into a bore hole (50) arranged in bone tissue, said implant having a cancellous portion (3), and a cortical portion (2) having an axial length such that, when installed in the bore hole (50), the engagement of said cortical portion (2) with the bone tissue will generally be confined to the cortical bone tissue layer (52). Said cortical portion (2) presents an outer surface which is threaded for accomplishing said engagement, and has an outer design such that, when being screwed into said bore hole under action of a screwing torque, said cortical portion (2) acts so as to increase the compression of the cortical bone tissue only, in essentially radial directions of the implant, resulting in a distinct increase of the screwing torque needed for screwing the implant (1). Said increase is usable as an indication that the implant (1) is in place or nearly in place in the bore hole.The invention also relates to an arrangement comprising an implant and a bore hole, and a method for insertion of an implant into a bore hole.
摘要:
A fixture, for use in a dental implant system, of the type having an upper portion with a conically flaring outer surface. The conically flaring outer surface is provided with a circumferentially oriented, defined micro-roughness, preferably in the form of threads or beads, having a height between 0.02 and 0.20 mm, and most preferably approximately 0.1 mm. In the preferred embodiment, the distance between adjacent threads or beads, crest to crest, is approximately twice the height of the threads or beads, respectively.
摘要:
The present invention relates to Acetyl Coenzyme A Carboxylase (ACC) inhibitors according to formula (I), or an enantiomer thereof, or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, E, L, Z and n are as defined herein, to processes for preparing such compounds, to pharmaceutical compositions containing them, to the use of such inhibitors and to methods for their therapeutic use, particularly in the treatments of obesity and diabetes mellitus.
摘要:
Novel compounds of formula I, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; and ii) (2R/S,3R)-(3-amino-2-hydroxybutyl)phosphinic acid, having affinity to one or more GABAB receptors, their pharmaceutically acceptable salts, solvates and stereoisomers, as well as processes for their preparation, pharmaceutical compositions containing said therapeutically active compounds and the use of said active compounds in therapy.