公开(公告)号：US09089152B2

公开(公告)日：2015-07-28

申请号：US13264381

申请日：2010-04-13

Applicant: Andre Brodkorb ,  Sinead Doherty

Inventor： Andre Brodkorb ,  Sinead Doherty

IPC: A23L1/00 ,  A23L1/052 ,  A23P1/04 ,  A61K9/16 ,  B01J13/02 ,  B01J13/04 ,  B01J13/22 ,  A23L1/211 ,  A23L1/30 ,  A23L1/305 ,  B01J13/00

CPC classification number: A23L1/0029 ,  A23L11/34 ,  A23L29/206 ,  A23L33/135 ,  A23L33/19 ,  A23P10/30 ,  A23V2002/00 ,  B01J13/0065 ,  A23V2200/224 ,  A23V2250/54252 ,  A23V2200/3204

Abstract: A method for producing microbeads comprising an active component encapsulated within a gelled polymer matrix comprises the steps of providing a suspension of denatured whey protein and an active component, treating the suspension to generate microbeads, and immediately curing the microbeads by acidification. The microbeads are discrete droplets of gelled whey protein having an average diameter in the micron range (for example, from 80 to 500 microns) and which, suitably have a generally spherical shape. The microbeads are capable of surviving passage through the stomach, and delivering the encapsulated active agent in the instestine. Ex-vivo and in-vivo data shows that active agent encapsulated within microbeads retains its functionality upon delivery to the intestine, and that coating of the microcapsules allows targeted delivery of the active agent to the distal part of the intestine.

Abstract translation: 包含包封在胶凝聚合物基质内的活性组分的微珠的制备方法包括提供变性乳清蛋白和活性组分的悬浮液，处理悬浮液以产生微珠并通过酸化立即固化微珠的步骤。 微珠是具有微米范围（例如，80至500微米）的平均直径的凝胶化乳清蛋白的离散液滴，并且适当地具有大致球形的形状。 微珠能够通过胃部存活，并将封装的活性剂输送到肠内。 离体和体内数据表明，包封在微珠内的活性剂在递送到肠道时保持其功能，并且微胶囊的包衣允许活性剂靶向递送至肠的远端部分。

公开(公告)号：US20120156252A1

公开(公告)日：2012-06-21

申请号：US13264381

申请日：2010-04-13

Applicant: Andre Brodkorb ,  Sinead Doherty

Inventor： Andre Brodkorb ,  Sinead Doherty

IPC: A61K9/14 ,  A61P1/14 ,  A61J3/00 ,  A61K35/74

CPC classification number: A23L1/0029 ,  A23L11/34 ,  A23L29/206 ,  A23L33/135 ,  A23L33/19 ,  A23P10/30 ,  A23V2002/00 ,  B01J13/0065 ,  A23V2200/224 ,  A23V2250/54252 ,  A23V2200/3204

Abstract: A method for producing microbeads comprising an active component encapsulated within a gelled polymer matrix comprises the steps of providing a suspension of denatured whey protein and an active component, treating the suspension to generate microbeads, and immediately curing the microbeads by acidification. The microbeads are discrete droplets of gelled whey protein having an average diameter in the micron range (for example, from 80 to 500 microns) and which, suitably have a generally spherical shape. The microbeads are capable of surviving passage through the stomach, and delivering the encapsulated active agent in the instestine. Ex-vivo and in-vivo data shows that active agent encapsulated within microbeads retains its functionality upon delivery to the intestine, and that coating of the microcapsules allows targeted delivery of the active agent to the distal part of the intestine.

Abstract translation: 包含包封在胶凝聚合物基质内的活性组分的微珠的制备方法包括提供变性乳清蛋白和活性组分的悬浮液，处理悬浮液以产生微珠并通过酸化立即固化微珠的步骤。 微珠是具有微米范围（例如，80至500微米）的平均直径的凝胶化乳清蛋白的离散液滴，并且适当地具有大致球形的形状。 微珠能够通过胃部存活，并将封装的活性剂输送到肠内。 离体和体内数据表明，包封在微珠内的活性剂在递送到肠道时保持其功能，并且微胶囊的包衣允许活性剂靶向递送至肠的远端部分。