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公开(公告)号：US10316304B2
公开(公告)日：2019-06-11
申请号：US13512202
申请日：2010-11-26
摘要： The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more Zn2C6 zinc fingers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.
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公开(公告)号：US09404099B2
公开(公告)日：2016-08-02
申请号：US13512219
申请日：2010-11-25
申请人： Andrea Hlubek , Christian Biesgen
发明人： Andrea Hlubek , Christian Biesgen
摘要： Provided are optimized endonucleases, as well as methods of targeted integration, targeted deletion or targeted mutation of [polynucleotides using optimized endonucleases.
摘要翻译： 提供优化的内切核酸酶，以及使用优化的内切核酸酶的多核苷酸的靶向整合，靶向缺失或靶向突变的方法。
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公开(公告)号：US20120324603A1
公开(公告)日：2012-12-20
申请号：US13511727
申请日：2010-11-26
IPC分类号： C12N9/22 , C12N15/62 , C12N15/63 , C07H21/04 , A01H5/00 , C12N1/19 , C12N5/10 , C12N1/13 , C12Q1/68 , C12N15/87 , C12N15/55 , C12N1/15
CPC分类号： C12N15/8213 , C07K2319/80 , C07K2319/81 , C12N9/22 , C12N15/1082
摘要： The invention relates to chimeric endonucleases, comprising an endonuclease and a heterologous DNA binding domain, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.
摘要翻译： 本发明涉及包含核酸内切酶和异源DNA结合结构域的嵌合核酸内切酶，以及使用嵌合内切核酸酶的多核苷酸的靶向整合，靶向缺失或靶向突变的方法。
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公开(公告)号：US20120284877A1
公开(公告)日：2012-11-08
申请号：US13512202
申请日：2010-11-26
CPC分类号： C12N9/22 , C07K14/4702 , C12N15/8213
摘要： The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more Zn2C6 zinc fmgers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.
摘要翻译： 本发明涉及嵌合核酸内切酶，其包含内切核酸酶和包含一种或多种Zn2C6锌化合物的异源DNA结合结构域，以及使用嵌合内切核酸酶的多核苷酸的靶向整合，靶向缺失或靶向突变的方法。
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公开(公告)号：US20120246764A1
公开(公告)日：2012-09-27
申请号：US13512219
申请日：2010-11-25
申请人： Andrea Hlubek , Christian Biesgen
发明人： Andrea Hlubek , Christian Biesgen
摘要： Provided are optimized endonucleases, as well as methods of targeted integration, targeted deletion or targeted mutation of [polynucleotides using optimized endonucleases.
摘要翻译： 提供优化的内切核酸酶，以及使用优化的内切核酸酶的多核苷酸的靶向整合，靶向缺失或靶向突变的方法。
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