公开(公告)号：US20110089041A1

公开(公告)日：2011-04-21

申请号：US12581483

申请日：2009-10-19

Applicant: Gautam GUPTA ,  Andreas Sewing

Inventor： Gautam GUPTA ,  Andreas Sewing

IPC: C25D5/54 ,  C25D9/04 ,  C25D5/34

CPC classification number: C25D9/08 ,  C25D5/18 ,  C25D5/48

Abstract: A method for electrochemically depositing discrete regions of calcium phosphate onto a medical implant. The method includes providing an implant including at least one area having a metallic surface. At least a portion of the metallic surface is contacted with an electrolyte solution comprising calcium ions and phosphate ions. The metallic surface is used as a cathode, and an electrical potential is applied between the cathode and the electrolyte solution. The electrical potential is applied with a constant current density of from about 10 to about 50 mA/cm2 for a period of time of from about 1 to about 20 minutes. A plurality of discrete regions of needle-shaped hydroxyapatite crystals are electrochemically deposited onto the metallic surface.

Abstract translation: 电化学沉积磷酸钙离散区域到医用植入物上的方法。 该方法包括提供包括具有金属表面的至少一个区域的植入物。 金属表面的至少一部分与包含钙离子和磷酸根离子的电解质溶液接触。 金属表面用作阴极，并且在阴极和电解质溶液之间施加电势。 以约10至约50mA / cm 2的恒定电流密度施加电位约1至约20分钟的时间。 针状羟基磷灰石晶体的多个离散区域电化学沉积在金属表面上。

公开(公告)号：US07229545B2

公开(公告)日：2007-06-12

申请号：US10414284

申请日：2003-04-16

Applicant: Andreas Sewing ,  Michel Dard ,  Sophie Roessler ,  Dieter Scharnweber ,  Hartmut Worch

Inventor： Andreas Sewing ,  Michel Dard ,  Sophie Roessler ,  Dieter Scharnweber ,  Hartmut Worch

IPC: C25D9/04 ,  A61L27/28

CPC classification number: A61L27/34 ,  A61L2430/02 ,  A61L27/46 ,  A61L27/54 ,  C08L89/06

Abstract: A biomimetically produced bone-analogous coating, comprising organic and inorganic main constituents, is suitable for coating metallic implant materials of any desired surfaces. The coating comprises a collagen matrix mineralized with calcium phosphate.

Abstract translation: 包含有机和无机主要成分的生物测量生产的骨 - 类似涂层适用于涂覆任何所需表面的金属植入材料。 该涂层包括用磷酸钙矿化的胶原基质。

公开(公告)号：US20050079198A1

公开(公告)日：2005-04-14

申请号：US10918743

申请日：2004-08-16

Applicant: Berthold Nies ,  Andreas Sewing ,  Dieter Scharnweber ,  Hartmut Worch ,  Rene Beutner

Inventor： Berthold Nies ,  Andreas Sewing ,  Dieter Scharnweber ,  Hartmut Worch ,  Rene Beutner

IPC: A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  C25D9/02 ,  A61N1/00 ,  A61F2/00

CPC classification number: C25D9/02 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/232 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/426 ,  A61L2300/606 ,  C08L5/08

Abstract: The invention describes an article made from chitosan-coated metal, where an impermeable chitosan layer having a barrier action is present on the metal through electrochemical polarisation in a chitosan-containing solution. The incorporation of biologically active components into the chitosan coating enables the coating to be matched to various applications and the bio-compatibility of correspondingly modified surfaces to be increased. Metallic articles or surfaces coated in this way are used, for example, as material for medical implants.

Abstract translation: 本发明描述了由壳聚糖涂覆的金属制成的制品，其中通过在含壳聚糖的溶液中的电化学极化，在金属上存在具有屏障作用的不可渗透的壳聚糖层。 将生物活性成分并入壳聚糖涂层中使得涂层能够匹配各种应用，并且相应改性表面的生物相容性增加。 以这种方式涂覆的金属制品或表面例如用作医疗植入物的材料。