公开(公告)号：US09351973B2

公开(公告)日：2016-05-31

申请号：US14346518

申请日：2012-09-17

申请人： D. Jonathan Bennett ,  Jaiqiang Cai ,  Emma Carswell ,  Andrew Cooke ,  Scott B. Hoyt ,  Clare London ,  John MacLean ,  Min K. Park ,  Paul Ratcliffe ,  Yusheng Xiong ,  Swapan Kumar Samanta ,  Bheemashankar A. Kulkarni

发明人： D. Jonathan Bennett ,  Jaiqiang Cai ,  Emma Carswell ,  Andrew Cooke ,  Scott B. Hoyt ,  Clare London ,  John MacLean ,  Min K. Park ,  Paul Ratcliffe ,  Yusheng Xiong ,  Swapan Kumar Samanta ,  Bheemashankar A. Kulkarni

IPC分类号： C07D471/04 ,  A61K31/437 ,  C07D487/04 ,  A61K31/519 ,  A61P9/12 ,  A61P13/12 ,  A61P9/00 ,  A61P9/10 ,  A61P1/16

CPC分类号： A61K31/519 ,  A61K31/437 ,  A61K31/444 ,  C07D471/04 ,  C07D487/04

摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

摘要翻译： 本发明涉及以下结构式的吡唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。

公开(公告)号：US09173873B2

公开(公告)日：2015-11-03

申请号：US14346403

申请日：2012-09-17

申请人： Amjad Ali ,  D. Jonathan Bennett ,  Jaiqiang Cai ,  Emma Carswell ,  Andrew Cooke ,  Scott B. Hoyt ,  Michael Lo ,  Clare London ,  John MacLean ,  Min K. Park ,  Paul Ratcliffe ,  Jerry Andrew Taylor ,  Brent Whitehead ,  Yusheng Xiong

发明人： Amjad Ali ,  D. Jonathan Bennett ,  Jaiqiang Cai ,  Emma Carswell ,  Andrew Cooke ,  Scott B. Hoyt ,  Michael Lo ,  Clare London ,  John MacLean ,  Min K. Park ,  Paul Ratcliffe ,  Jerry Andrew Taylor ,  Brent Whitehead ,  Yusheng Xiong

IPC分类号： A61K31/437 ,  C07D471/04 ,  C07D487/04

摘要： This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

公开(公告)号：US20130317057A1

公开(公告)日：2013-11-28

申请号：US13811059

申请日：2011-07-20

申请人： Scott B. Hoyt ,  Min K. Park ,  Clare London ,  Yusheng Xiong ,  D. Jonathan Bennett ,  Jaiqiang Cai ,  Paul Ratcliffe ,  Andrew Cooke ,  Emma Carswell ,  John MacLean ,  Rohit Saxena ,  Bheemashankar A. Kulkarni ,  Archana Gupta

发明人： Scott B. Hoyt ,  Min K. Park ,  Clare London ,  Yusheng Xiong ,  D. Jonathan Bennett ,  Jaiqiang Cai ,  Paul Ratcliffe ,  Andrew Cooke ,  Emma Carswell ,  John MacLean ,  Rohit Saxena ,  Bheemashankar A. Kulkarni ,  Archana Gupta

IPC分类号： C07D401/04 ,  C07D413/14 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4439 ,  C07D471/04

CPC分类号： C07D401/04 ,  A61K31/4184 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4709 ,  C07D413/14 ,  C07D471/04

摘要： The invention involves compounds of structural Formula (I) and the pharmaceutically acceptable salts thereof. The compounds of the invention are effective at selectively inhibiting CYP11B2, and are therefore useful for the treatment or prophylaxis of disorders that are associated with elevated aldosterone levels, including, but not limited to, hypertension and heart failure.

摘要翻译： 本发明涉及结构式（I）的化合物及其药学上可接受的盐。 本发明的化合物对选择性抑制CYP11B2有效，因此可用于治疗或预防与升高的醛固酮水平相关的病症，包括但不限于高血压和心力衰竭。

公开(公告)号：US20110304560A1

公开(公告)日：2011-12-15

申请号：US12892848

申请日：2010-09-28

申请人： Thomas Andrew Cooke Dale ,  Christopher Brian Fleizach

发明人： Thomas Andrew Cooke Dale ,  Christopher Brian Fleizach

IPC分类号： G06F3/041

CPC分类号： G06F3/04886 ,  G06F3/0488

摘要： A method includes displaying a user interface of an application on a device's touch-sensitive display. The user interface includes a plurality of regions, including a respective region at a respective hierarchy level. The respective region has two or more child regions at a hierarchy level below the respective hierarchy level. The method includes detecting a first contact at a location that corresponds to the respective region and that does not correspond to any of the two or more child regions. When the application is configured to process the first contact, not in conjunction with the respective region, but in conjunction with at least one child region of the two or more child regions, the method includes identifying a respective child region in accordance with positions of the child regions relative to the location, and processing the first contact in conjunction with the identified respective child region using the application.

公开(公告)号：US06180635B2

公开(公告)日：2001-01-30

申请号：US09117426

申请日：1998-07-30

申请人： David Cheshire ,  Andrew Cooke ,  Martin Cooper ,  David Donald ,  Mark Furber ,  Matthew Perry ,  Philip Thorne

发明人： David Cheshire ,  Andrew Cooke ,  Martin Cooper ,  David Donald ,  Mark Furber ,  Matthew Perry ,  Philip Thorne

IPC分类号： C07D49504

CPC分类号： C07D495/04

摘要： The invention provides pharmaceutically useful thieno[2,3-d]pyrimidinediones, processes for their production, pharmaceutical compositions containing them and methods of treatment involving their use.

摘要翻译： 本发明提供药学上有用的噻吩并[2,3-d]嘧啶并二酮，其制备方法，含有它们的药物组合物和涉及其用途的治疗方法。

公开(公告)号：US1992086A

公开(公告)日：1935-02-19

申请号：US72720434

申请日：1934-05-23

申请人： WILLIAM MEREDITH FREDERICK ,  ANDREW COOKE PHILIP

发明人： WILLIAM MEREDITH FREDERICK ,  ANDREW COOKE PHILIP

IPC分类号： G01C21/18

CPC分类号： G01C21/18 ,  Y10T74/1261

公开(公告)号：US10216408B2

公开(公告)日：2019-02-26

申请号：US12892851

申请日：2010-09-28

申请人： Thomas Andrew Cooke Dale ,  Christopher Brian Fleizach

发明人： Thomas Andrew Cooke Dale ,  Christopher Brian Fleizach

IPC分类号： G06F3/048 ,  G06F3/0488

摘要： A method includes displaying a user interface of an application on a device's touch-sensitive display. The user interface includes a plurality of regions, including a respective region at a respective hierarchy level. The respective region has two or more child regions at a hierarchy level below the respective hierarchy level. The method includes detecting a first contact at a location that corresponds to the respective region and that does not correspond to any of the two or more child regions. When the application is configured to process the first contact, not in conjunction with the respective region, but in conjunction with at least one child region of the two or more child regions, the method includes identifying a respective child region in accordance with positions of the child regions relative to the location, and processing the first contact in conjunction with the identified respective child region using the application.

公开(公告)号：US08552999B2

公开(公告)日：2013-10-08

申请号：US12892848

申请日：2010-09-28

申请人： Thomas Andrew Cooke Dale ,  Christopher Brian Fleizach

发明人： Thomas Andrew Cooke Dale ,  Christopher Brian Fleizach

IPC分类号： G06F3/041 ,  G06F3/048

CPC分类号： G06F3/04886 ,  G06F3/0488

摘要： A method includes displaying a user interface of an application on a device's touch-sensitive display. The user interface includes a plurality of regions, including a respective region at a respective hierarchy level. The respective region has two or more child regions at a hierarchy level below the respective hierarchy level. The method includes detecting a first contact at a location that corresponds to the respective region and that does not correspond to any of the two or more child regions. When the application is configured to process the first contact, not in conjunction with the respective region, but in conjunction with at least one child region of the two or more child regions, the method includes identifying a respective child region in accordance with positions of the child regions relative to the location, and processing the first contact in conjunction with the identified respective child region using the application.

摘要翻译： 一种方法包括在设备的触敏显示器上显示应用的用户界面。 用户界面包括多个区域，包括相应层级的相应区域。 相应的区域具有在相应层级下面的层级下的两个或更多个子区域。 该方法包括在对应于相应区域并且不对应于两个或更多个子区域中的任一个的位置处检测第一联系人。 当所述应用被配置为处理所述第一联系人时，不与所述相应区域结合，而是与所述两个或更多个子区域的至少一个子区域结合，所述方法包括根据所述第二联系人的位置识别相应的子区域 子区域，并且使用应用程序结合所识别的相应子区域处理第一联系人。

公开(公告)号：US20070021482A1

公开(公告)日：2007-01-25

申请号：US10575380

申请日：2004-10-20

申请人： Niall Hamilton ,  Susan Napier ,  Morag Easson ,  Andrew Cooke ,  Lene Teuber ,  Naheed Mirza ,  Frank Watjen

发明人： Niall Hamilton ,  Susan Napier ,  Morag Easson ,  Andrew Cooke ,  Lene Teuber ,  Naheed Mirza ,  Frank Watjen

IPC分类号： A61K31/4184 ,  C07D235/04

CPC分类号： A61K31/4184 ,  C07D235/06 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D403/06 ,  C07D403/12 ,  C07D405/04

摘要： This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex.

摘要翻译： 本发明涉及新的1,5,7-三取代苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应。

公开(公告)号：US06984644B2

公开(公告)日：2006-01-10

申请号：US10265201

申请日：2002-10-07

申请人： David Cheshire ,  Andrew Cooke ,  Martin Cooper ,  David Donald ,  Mark Furber ,  Matthew Perry ,  Philip Thorne

发明人： David Cheshire ,  Andrew Cooke ,  Martin Cooper ,  David Donald ,  Mark Furber ,  Matthew Perry ,  Philip Thorne

IPC分类号： A61K31/519 ,  C07D495/04

CPC分类号： C07D495/04

摘要： The invention provides pharmaceutically useful thieno[2,3-d]pyrimidinediones, processes for their production, pharmaceutical compositions containing them and methods of treatment involving their use.

摘要翻译： 本发明提供药学上有用的噻吩并[2,3-d]嘧啶并二酮，其制备方法，含有它们的药物组合物和涉及其用途的治疗方法。