-
![Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon](/abs-image/US/2008/07/22/US07402672B2/abs.jpg.150x150.jpg)
1.发明授权Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon 有权取代的1H-吡咯并[3,2-b，3,2-c和2,3-c]吡啶-2-甲酰胺和相关类似物作为酪蛋白激酶lepsilon的抑制剂公开(公告)号：US07402672B2
公开(公告)日：2008-07-22
申请号：US11001533
申请日：2004-12-01
申请人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Antonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
发明人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Antonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求作为人酪蛋白激酶IF抑制剂的式（I）化合物，以及使用所述式（I）化合物治疗中枢神经系统疾病和病症（包括情绪障碍和睡眠障碍）的方法。 还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。
-
![Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon](/abs-image/US/2005/06/16/US20050131012A1/abs.jpg.150x150.jpg)
2.发明申请Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon 有权取代的1H-吡咯并[3,2-b，3,2-c和2,3-c]吡啶-2-甲酰胺和相关类似物作为酪蛋白激酶lepsilon的抑制剂公开(公告)号：US20050131012A1
公开(公告)日：2005-06-16
申请号：US11001533
申请日：2004-12-01
申请人： William Metz , Frank Halley , Gilles Dutruc-Rosset , Yong Choi-Sledeski , Gregory Bernard Poli , David Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Gelormini , Juan Gamboa , Andrew Giovanni , Joachim Roehr , Joseph Tsay , Fernando Camacho , William Hurst , Stephen Harnish , Yulin Chiang
发明人： William Metz , Frank Halley , Gilles Dutruc-Rosset , Yong Choi-Sledeski , Gregory Bernard Poli , David Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Gelormini , Juan Gamboa , Andrew Giovanni , Joachim Roehr , Joseph Tsay , Fernando Camacho , William Hurst , Stephen Harnish , Yulin Chiang
IPC分类号： A61K31/437 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求作为人酪蛋白激酶IF抑制剂的式（I）化合物，以及使用所述式（I）化合物治疗中枢神经系统疾病和病症（包括情绪障碍和睡眠障碍）的方法。 还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。
-
![Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase Iε](/abs-image/US/2009/12/01/US07626027B2/abs.jpg.150x150.jpg)
3.发明授权Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase Iε 有权取代的1H-吡咯并[2,3-c]吡啶-2-甲酰胺和相关类似物作为酪蛋白激酶Iepsilon的抑制剂公开(公告)号：US07626027B2
公开(公告)日：2009-12-01
申请号：US12106681
申请日：2008-04-21
申请人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Anotonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
发明人： William A. Metz, Jr. , Frank Halley , Gilles Dutruc-Rosset , Yong Mi Choi-Sledeski , Gregory Bernard Poli , David Marc Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Marie Gelormini , Juan Anotonio Gamboa , Andrew Giovanni , Joachim E. Roehr , Joseph T. Tsay , Fernando Camacho , William Joseph Hurst , Stephen Wayne Harnish , Yulin Chiang
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase Iε, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求其中M为N的式（I）化合物，并且K和L各自为C，其余取代基进一步定义。 这些化合物作为人酪氨酸激酶Iepsilon的抑制剂是有效的，因此可用于治疗中枢神经系统疾病和病症，包括情绪障碍和睡眠障碍。 还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。
-
![SUBSTITUTED 1H-PYRROLO[3,2-b, 3,2-c, and 2,3-c]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Ie](/abs-image/US/2008/08/21/US20080200496A1/abs.jpg.150x150.jpg)
4.发明申请SUBSTITUTED 1H-PYRROLO[3,2-b, 3,2-c, and 2,3-c]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Ie 有权取代的1H-吡咯并[3,2-b，3,2-c和2,3-c]吡啶-2-羧酰胺和相关的作为CASEIN KINASE的抑制剂的类似物公开(公告)号：US20080200496A1
公开(公告)日：2008-08-21
申请号：US12106681
申请日：2008-04-21
申请人： William A. METZ , Frank HALLEY , Gilles DUTRUC-ROSSET , Yong Mi CHOI-SLEDESKI , Gregory Bernard POLI , David Marc FINK , Gilles DOERFLINGER , Bao-Guo HUANG , Ann Marie GELORMINI , Juan Antonio GAMBOA , Andrew GIOVANNI , Joachim E. ROEHR , Joseph T. TSAY , Fernando CAMACHO , William Joseph HURST , Stephen Wayne HARNISH , Yulin CHIANG
发明人： William A. METZ , Frank HALLEY , Gilles DUTRUC-ROSSET , Yong Mi CHOI-SLEDESKI , Gregory Bernard POLI , David Marc FINK , Gilles DOERFLINGER , Bao-Guo HUANG , Ann Marie GELORMINI , Juan Antonio GAMBOA , Andrew GIOVANNI , Joachim E. ROEHR , Joseph T. TSAY , Fernando CAMACHO , William Joseph HURST , Stephen Wayne HARNISH , Yulin CHIANG
IPC分类号： A61K31/437 , C07D401/14 , C07D471/04 , A61K31/407 , C07D487/04 , A61K31/4439 , A61P25/24 , A61P25/20
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase Iε, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译： 本发明公开并要求其中M为N的式（I）化合物，并且K和L各自为C，其余取代基进一步定义。 这些化合物作为人酪氨酸激酶Iepsilon的抑制剂是有效的，因此可用于治疗中枢神经系统疾病和病症，包括情绪障碍和睡眠障碍。 还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。
-
-
-
搜索结果
4 条记录 (耗时 0.015 秒)
