公开(公告)号：US20090018141A1

公开(公告)日：2009-01-15

申请号：US12135575

申请日：2008-06-09

Applicant: Robert Shoemaker ,  John Cardellina ,  Michael Currens ,  Sudhir Kondapaka ,  Yves Pommier ,  Andy Jobson ,  Dominic Scudiero ,  David Waugh ,  George Lountos ,  Charles M. Cook ,  Guangtao Zhang ,  Andrew Colasanti ,  Christopher R. Self ,  Janet Cicariello Cook

Inventor： Robert Shoemaker ,  John Cardellina ,  Michael Currens ,  Sudhir Kondapaka ,  Yves Pommier ,  Andy Jobson ,  Dominic Scudiero ,  David Waugh ,  George Lountos ,  Charles M. Cook ,  Guangtao Zhang ,  Andrew Colasanti ,  Christopher R. Self ,  Janet Cicariello Cook

IPC: A61K31/496 ,  A61K31/17 ,  C07C275/40 ,  A61K31/404 ,  C07D209/42 ,  C07D403/12 ,  C12N9/99 ,  A61P3/10 ,  A61K31/444 ,  C07D401/12 ,  A61K31/495 ,  C07D241/04

CPC classification number: C07D209/42 ,  C07D209/60 ,  C07D213/86 ,  C07D217/26 ,  C07D231/56 ,  C07D233/52 ,  C07D239/42 ,  C07D277/50 ,  C07D277/82 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

Abstract: Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.

Abstract translation: 本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法 可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。

公开(公告)号：US08765802B2

公开(公告)日：2014-07-01

申请号：US12135575

申请日：2008-06-09

Applicant: Robert Shoemaker ,  John Cardellina ,  Michael Currens ,  Sudhir Kondapaka ,  Yves Pommier ,  Andy Jobson ,  Dominic Scudiero ,  David Waugh ,  George Lountos ,  Guangtao Zhang ,  Andrew Colasanti ,  Christopher R. Self ,  Janet Cicariello Cook

Inventor： Robert Shoemaker ,  John Cardellina ,  Michael Currens ,  Sudhir Kondapaka ,  Yves Pommier ,  Andy Jobson ,  Dominic Scudiero ,  David Waugh ,  George Lountos ,  Charles M. Cook ,  Guangtao Zhang ,  Andrew Colasanti ,  Christopher R. Self

IPC: A61K31/40 ,  C07D209/42

CPC classification number: C07D209/42 ,  C07D209/60 ,  C07D213/86 ,  C07D217/26 ,  C07D231/56 ,  C07D233/52 ,  C07D239/42 ,  C07D277/50 ,  C07D277/82 ,  C07D307/68 ,  C07D307/85 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

Abstract: Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.

Abstract translation: 本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法 可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。