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公开(公告)号：US20090018141A1
公开(公告)日：2009-01-15
申请号：US12135575
申请日：2008-06-09
Applicant: Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
Inventor： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
IPC: A61K31/496 , A61K31/17 , C07C275/40 , A61K31/404 , C07D209/42 , C07D403/12 , C12N9/99 , A61P3/10 , A61K31/444 , C07D401/12 , A61K31/495 , C07D241/04
CPC classification number: C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
Abstract: Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
Abstract translation: 本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法 可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。
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公开(公告)号：US20100069423A1
公开(公告)日：2010-03-18
申请号：US11989737
申请日：2006-07-27
Applicant: Yves Pommier , Robert H. Shoemaker , Dominic Scudiero , Michael Currens , John Cardellina , Andrew Jobson
Inventor： Yves Pommier , Robert H. Shoemaker , Dominic Scudiero , Michael Currens , John Cardellina , Andrew Jobson
IPC: A61K31/437 , A61K31/17 , C07C275/28 , A61K31/155 , C07C251/32 , A61K31/15 , A61P35/00
CPC classification number: A61K31/17 , A61K31/175 , A61K31/4184 , C07C251/44 , C07C281/16 , C07C2603/18
Abstract: Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Abstract translation: 本文描述了Chk2抑制剂化合物及其衍生物，以及使用该化合物及其组合物治疗或预防疾病和疾病症状的方法。
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Patent Agency Ranking
3.发明授权Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid 失效鉴定抗HIV化合物抑制病毒装配和核衣壳蛋白与核酸的结合公开(公告)号：US07572828B2
公开(公告)日：2009-08-11
申请号：US10528747
申请日：2003-10-08
Applicant: Robert H. Shoemaker , Michael Currens , Alan Rein , Hang Yuan, legal representative , Robert Fisher , Andrew Stephen , Karen Worthy , Shizuko Sei , Bruce Crise , Louis E. Henderson
Inventor： Ya-Xiong Feng
CPC classification number: A61K31/194 , A61K31/29 , A61K45/06 , G01N33/68
Abstract: The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.
Abstract translation: 本发明提供用于抑制病毒复制，特别是逆转录病毒复制的方法和药物组合物。 所述方法包括施用破坏病毒核衣壳与核酸结合的苯乙烯酸或二苯基化合物。
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公开(公告)号：US08765802B2
公开(公告)日：2014-07-01
申请号：US12135575
申请日：2008-06-09
Applicant: Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Guangtao Zhang , Andrew Colasanti , Christopher R. Self , Janet Cicariello Cook
Inventor： Robert Shoemaker , John Cardellina , Michael Currens , Sudhir Kondapaka , Yves Pommier , Andy Jobson , Dominic Scudiero , David Waugh , George Lountos , Charles M. Cook , Guangtao Zhang , Andrew Colasanti , Christopher R. Self
IPC: A61K31/40 , C07D209/42
CPC classification number: C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
Abstract: Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
Abstract translation: 本文提供具有以下结构的化合物：其中A，L，X和环B如本文所定义，包含有效量的化合物的组合物和用于治疗或预防癌症，缺氧，糖尿病，中风，自身免疫疾病或病症的方法 可通过抑制Chk2，ATM-Chk2途径或RSK2治疗或预防，包括向有需要的患者施用有效量的化合物。
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5.发明申请Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid 失效鉴定抗-Hiv化合物抑制病毒装配和核衣壳蛋白与核酸的结合公开(公告)号：US20060263772A1
公开(公告)日：2006-11-23
申请号：US10528747
申请日：2003-10-08
Applicant: Robert Shoemaker , Michael Currens , Alan Rein , Ya-Xiong Feng , Robert Fisher , Andrew Stephen , Karen Worthy , Shizuko Sei , Bruce Crise , Louis Henderson
Inventor： Robert Shoemaker , Michael Currens , Alan Rein , Ya-Xiong Feng , Robert Fisher , Andrew Stephen , Karen Worthy , Shizuko Sei , Bruce Crise , Louis Henderson
CPC classification number: A61K31/194 , A61K31/29 , A61K45/06 , G01N33/68
Abstract: The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or diphenyl compounds that disrupt viral nucleocapsid binding to nucleic acids.
Abstract translation: 本发明提供用于抑制病毒复制，特别是逆转录病毒复制的方法和药物组合物。 所述方法包括施用破坏病毒核衣壳与核酸结合的苯乙烯酸或二苯基化合物。
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公开(公告)号：US08912214B2
公开(公告)日：2014-12-16
申请号：US11989737
申请日：2006-07-27
Applicant: Yves Pommier , Robert H. Shoemaker , Dominic Scudiero , Michael Currens , John Cardellina , Andrew Jobson
Inventor： Yves Pommier , Robert H. Shoemaker , Dominic Scudiero , Michael Currens , John Cardellina , Andrew Jobson
IPC: A61K31/437 , A61K31/15 , A61K31/17 , A61P35/00 , C07C275/28 , A61K31/4184 , C07C281/16 , C07C251/44 , A61K31/175
CPC classification number: A61K31/17 , A61K31/175 , A61K31/4184 , C07C251/44 , C07C281/16 , C07C2603/18
Abstract: Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Abstract translation: 本文描述了Chk2抑制剂化合物及其衍生物，以及使用该化合物及其组合物治疗或预防疾病和疾病症状的方法。
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公开(公告)号：US20060139754A1
公开(公告)日：2006-06-29
申请号：US11023857
申请日：2004-12-28
Applicant: Chester Bacon , Seth Kirk , Moses David , Michael Currens , Osei Owusu
Inventor： Chester Bacon , Seth Kirk , Moses David , Michael Currens , Osei Owusu
IPC: G02B5/124
CPC classification number: G02B5/124
Abstract: A prismatic retroreflective article has a transparent body portion and a layer of internally reflecting cube-corner optical elements having an open air-exposed rear surface at least a portion of which is more hydrophobic, more oleophobic, or both more hydrophobic and more oleophobic than the underlying cube-corner optical element. The article may be made by providing a transparent body portion bearing a layer of internally reflecting open air-exposed cube-corner optical elements; treating or coating at least a portion of the cube-corner elements to make the treated or coated portion more hydrophobic, more oleophobic, or both more hydrophobic and more oleophobic than the underlying cube-corner optical elements; and leaving such treated or coated portion exposed to the open air.
Abstract translation: 棱镜式回射制品具有透明主体部分和内部反射立体角光学元件层，其具有暴露于露天的后表面，其至少一部分疏水性更强，疏油性更强，或者疏水性更好，疏油性更强。 底层立体角光学元件。 该制品可以通过提供一个透明的主体部分制成，该透明主体部分带有内部反射的暴露于露天的立体角光学元件层; 处理或涂覆至少一部分立体角元件以使经处理或涂覆的部分比下面的立体角光学元件更疏水，疏油或更疏水并且更疏油; 并将这种经处理或涂覆的部分暴露于露天。
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