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公开(公告)号：US20060183108A1
公开(公告)日：2006-08-17
申请号：US11137935
申请日：2005-05-25
申请人： Hovsep Melkonyan , Angela Cannas , Louis Tomei , Samuil Umansky
发明人： Hovsep Melkonyan , Angela Cannas , Louis Tomei , Samuil Umansky
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
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2.发明申请METHOD FOR DIAGNOSIS AND MONITORING OF VIRAL INFECTION BY ANALYSIS OF VIRAL TRANSRENAL NUCLEIC ACIDS IN URINE 审中-公开尿毒症病毒分子核酸分析法检测和监测病毒感染的方法公开(公告)号：US20130178544A1
公开(公告)日：2013-07-11
申请号：US13777946
申请日：2013-02-26
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
摘要翻译： 本发明涉及用于通过检测在尿样中是否存在来自尿液样本的病毒来源的经肾上腺病毒核酸或核酸的存在来诊断或监测病毒感染的方法，其中或不分离来自尿液样品的核酸。 核酸的分析通过核酸与特异性探针的杂交，或通过与特异性引物的链扩增反应来进行。 所述方法适用于所有病毒致病剂，包括RNA，DNA，附加型或综合病毒。
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3.发明申请Compositions and Methods for Detecting Pathogen Specific Nucleic Acids in Urine 审中-公开用于检测尿液中病原体特异性核酸的组合物和方法公开(公告)号：US20120021412A1
公开(公告)日：2012-01-26
申请号：US13029308
申请日：2011-02-17
IPC分类号： C12Q1/68
CPC分类号： C07H21/04 , C12N15/1006 , Y02A50/55
摘要： The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp. Thus the invention provides compositions and methods for the diagnosis of infection of a subject with non-viral pathogens through the detection of transrenal nucleic acids from those pathogens in the urine of the subject.
摘要翻译： 本发明基于以下发现：当受试者感染非病毒病原体时，来自非病毒病原体的小核酸能够穿过肾脏并存在于受试者的尿液中。 这些跨肾脏DNA在大约300bp的较小尺寸下是特别普遍的。 因此，本发明提供了通过检测受试者尿液中的那些病原体的经肾上腺核酸来诊断患有非病毒病原体的受试者的感染的组合物和方法。
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4.发明申请Method for Diagnosis and Monitoring of Viral Infection by Analysis of Viral Transrenal Nucleic Acids in Urine 有权通过尿液中病毒性肾上腺核酸分析病毒感染的诊断和监测方法公开(公告)号：US20120021404A1
公开(公告)日：2012-01-26
申请号：US13114289
申请日：2011-05-24
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
摘要翻译： 本发明涉及用于通过检测在尿样中是否存在来自尿液样本的病毒来源的经肾上腺病毒核酸或核酸的存在来诊断或监测病毒感染的方法，其中或不分离来自尿液样品的核酸。 核酸的分析通过核酸与特异性探针的杂交，或通过与特异性引物的链扩增反应来进行。 所述方法适用于所有病毒致病剂，包括RNA，DNA，附加型或综合病毒。
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5.发明授权Kits for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine 有权通过分析尿液中的病毒性肾上腺核酸来诊断和监测病毒感染的试剂盒公开(公告)号：US07973154B2
公开(公告)日：2011-07-05
申请号：US11137935
申请日：2005-05-25
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
摘要翻译： 本发明涉及用于通过检测在尿样中是否存在来自尿液样本的病毒来源的经肾上腺病毒核酸或核酸的存在来诊断或监测病毒感染的方法，其中或不分离来自尿液样品的核酸。 核酸的分析通过核酸与特异性探针的杂交，或通过与特异性引物的链扩增反应来进行。 所述方法适用于所有病毒致病剂，包括RNA，DNA，附加型或综合病毒。
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6.发明授权Method for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine 有权通过分析尿液中的病毒性肾上腺核酸来诊断和监测病毒感染的方法公开(公告)号：US08383335B2
公开(公告)日：2013-02-26
申请号：US13114289
申请日：2011-05-24
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
摘要翻译： 本发明涉及用于通过检测在尿样中是否存在来自尿液样本的病毒来源的经肾上腺病毒核酸或核酸的存在来诊断或监测病毒感染的方法，其中或不分离来自尿液样品的核酸。 核酸的分析通过核酸与特异性探针的杂交，或通过与特异性引物的链扩增反应来进行。 所述方法适用于所有病毒致病剂，包括RNA，DNA，附加型或综合病毒。
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公开(公告)号：US07914982B2
公开(公告)日：2011-03-29
申请号：US11351799
申请日：2006-02-10
CPC分类号： C07H21/04 , C12N15/1006 , Y02A50/55
摘要： The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp. Thus the invention provides compositions and methods for the diagnosis of infection of a subject with non-viral pathogens through the detection of transrenal nucleic acids from those pathogens in the urine of the subject.
摘要翻译： 本发明基于以下发现：当受试者感染非病毒病原体时，来自非病毒病原体的小核酸能够穿过肾脏并存在于受试者的尿液中。 这些跨肾脏DNA在大约300bp的较小尺寸下是特别普遍的。 因此，本发明提供了通过检测受试者尿液中的那些病原体的经肾上腺核酸来诊断患有非病毒病原体的受试者的感染的组合物和方法。
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8.发明申请Compositions and methods for detecting pathogen specific nucleic acids in urine 有权用于检测尿液中病原体特异性核酸的组合物和方法公开(公告)号：US20070037181A1
公开(公告)日：2007-02-15
申请号：US11351799
申请日：2006-02-10
申请人： Hovsep Melkonyan , Angela Cannas , Louis Tomei , Samuil Umansky
发明人： Hovsep Melkonyan , Angela Cannas , Louis Tomei , Samuil Umansky
CPC分类号： C07H21/04 , C12N15/1006 , Y02A50/55
摘要： The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp. Thus the invention provides compositions and methods for the diagnosis of infection of a subject with non-viral pathogens through the detection of transrenal nucleic acids from those pathogens in the urine of the subject.
摘要翻译： 本发明基于以下发现：当受试者感染非病毒病原体时，来自非病毒病原体的小核酸能够穿过肾脏并存在于受试者的尿液中。 这些跨肾脏DNA在大约300bp的较小尺寸下是特别普遍的。 因此，本发明提供了通过检测受试者尿液中的那些病原体的经肾上腺核酸来诊断患有非病毒病原体的受试者的感染的组合物和方法。
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9.发明申请Method for diagnosis and monitoring of pathogenic infection by analysis of pathogenic transrenal nucleic acids in urine 有权通过分析尿液中的病原性肾上腺核酸来诊断和监测病原体感染的方法公开(公告)号：US20060183107A1
公开(公告)日：2006-08-17
申请号：US11137934
申请日：2005-05-25
申请人： Hovsep Melkonyan , Angela Cannas , Louis Tomei , Samuil Umansky
发明人： Hovsep Melkonyan , Angela Cannas , Louis Tomei , Samuil Umansky
CPC分类号： Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/451 , Y02A50/465 , Y02A50/469 , Y02A50/478 , Y02A50/491 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to a method for diagnosing and/or monitoring a bacterial or parasitic infection by detection and quantification of the transrenal nucleic acids, derived from bacterial pathogenic agents or from parasites, in urine. The detection method optionally includes the isolation and the purification of the nucleic acids from urine by methods known in the art including pairing with molecular probes that are specific for the pathogenic agents, PCR hybridization, PCR, nested PCR, SSCP, LCR, and SDA. Diagnostic kits based on these detection methods are also claimed.
摘要翻译： 本发明涉及通过检测和定量来自细菌致病剂或来自寄生虫的尿中的经肾核酸来诊断和/或监测细菌或寄生虫感染的方法。 检测方法任选地包括通过本领域已知的方法从尿中分离和纯化核酸，包括与对病原体，PCR杂交，PCR，巢式PCR，SSCP，LCR和SDA特异性的分子探针配对。 还要求基于这些检测方法的诊断试剂盒。
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10.发明授权Kits for diagnosis and monitoring of pathogenic infection by analysis of cell-free pathogenic nucleic acids in urine 有权通过分析尿液中无细胞致病性核酸的病原体感染诊断和监测试剂盒公开(公告)号：US07803929B2
公开(公告)日：2010-09-28
申请号：US11137934
申请日：2005-05-25
CPC分类号： Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/423 , Y02A50/451 , Y02A50/465 , Y02A50/469 , Y02A50/478 , Y02A50/491 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to a method for diagnosing and/or monitoring a bacterial or parasitic infection by detection and quantification of the transrenal nucleic acids, derived from bacterial pathogenic agents or from parasites, in urine. The detection method optionally includes the isolation and the purification of the nucleic acids from urine by methods known in the art including pairing with molecular probes that are specific for the pathogenic agents, PCR hybridization, PCR, nested PCR, SSCP, LCR, and SDA. Diagnostic kits based on these detection methods are also claimed.
摘要翻译： 本发明涉及通过检测和定量来自细菌致病剂或来自寄生虫的尿中的经肾核酸来诊断和/或监测细菌或寄生虫感染的方法。 检测方法任选地包括通过本领域已知的方法从尿中分离和纯化核酸，包括与对病原体，PCR杂交，PCR，巢式PCR，SSCP，LCR和SDA特异性的分子探针配对。 还要求基于这些检测方法的诊断试剂盒。
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