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公开(公告)号：US09168292B2
公开(公告)日：2015-10-27
申请号：US13823581
申请日：2011-09-07
IPC分类号： F16K31/62 , A61K39/015 , C12N15/86 , A61K39/00
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2710/10371 , C12N2799/022 , Y02A50/412
摘要： Described are methods for inducing an immune response in a subject against an antigen from a malaria-causing parasite, preferably P. falciparum, the method comprising: (i) administering to a subject a priming composition comprising adjuvanted proteinaceous antigen-comprising circumsporozoite (CS) protein or an immunogenic part thereof from a malaria-causing parasite; (ii) administering to the subject a first boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or immunogenic part thereof from a malaria-causing parasite; and (iii) administering to the subject a second boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or an immunogenic part thereof from a malaria-causing parasite, wherein either the first boosting composition comprises a recombinant adenovirus vector of serotype 35 (Ad35) and the second boosting composition comprises a recombinant adenovirus of Ad26, or wherein the first boosting composition comprises a recombinant adenovirus vector of Ad26 and the second boosting composition comprises a recombinant adenovirus of Ad35.
摘要翻译： 描述了在受试者中针对来自引起疟疾的寄生虫，优选恶性疟原虫的抗原诱导免疫应答的方法，所述方法包括：（i）向受试者施用包含佐剂化蛋白质抗原的环子孢子（CS）的引发组合物， 蛋白质或其免疫原性部分来自引起疟疾的寄生虫; （ii）向所述受试者施用包含重组腺病毒载体的第一加强组合物，所述重组腺病毒载体包含编码来自疟原虫寄生虫的CS蛋白或其免疫原性部分的核酸; 和（iii）向所述受试者施用包含重组腺病毒载体的第二增强组合物，所述重组腺病毒载体包含编码CS蛋白或其免疫原性部分的来自引起疟疾的寄生虫的核酸，其中所述第一加强组合物包含血清型35的重组腺病毒载体 （Ad35），第二增强组合物包含Ad26的重组腺病毒，或其中第一促进组合物包含Ad26的重组腺病毒载体，第二加强组合物包含Ad35的重组腺病毒。
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公开(公告)号：US20130216580A1
公开(公告)日：2013-08-22
申请号：US13823581
申请日：2011-09-07
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577 , C12N15/86 , C12N2710/10343 , C12N2710/10362 , C12N2710/10371 , C12N2799/022 , Y02A50/412
摘要： Described are methods for inducing an immune response in a subject against an antigen from a malaria-causing parasite, preferably P. falciparum, the method comprising: (i) administering to a subject a priming composition comprising adjuvanted proteinaceous antigen-comprising circumsporozoite (CS) protein or an immunogenic part thereof from a malaria-causing parasite; (ii) administering to the subject a first boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or immunogenic part thereof from a malaria-causing parasite; and (iii) administering to the subject a second boosting composition comprising a recombinant adenovirus vector that comprises nucleic acid encoding CS protein or an immunogenic part thereof from a malaria-causing parasite, wherein either the first boosting composition comprises a recombinant adenovirus vector of serotype 35 (Ad35) and the second boosting composition comprises a recombinant adenovirus of Ad26, or wherein the first boosting composition comprises a recombinant adenovirus vector of Ad26 and the second boosting composition comprises a recombinant adenovirus of Ad35.
摘要翻译： 描述了在受试者中针对来自引起疟疾的寄生虫，优选恶性疟原虫的抗原诱导免疫应答的方法，所述方法包括：（i）向受试者施用包含佐剂化蛋白质抗原的环子孢子（CS）的引发组合物， 蛋白质或其免疫原性部分来自引起疟疾的寄生虫; （ii）向所述受试者施用包含重组腺病毒载体的第一加强组合物，所述重组腺病毒载体包含编码来自疟原虫寄生虫的CS蛋白或其免疫原性部分的核酸; 和（iii）向所述受试者施用包含重组腺病毒载体的第二增强组合物，所述重组腺病毒载体包含编码CS蛋白或其免疫原性部分的来自引起疟疾的寄生虫的核酸，其中所述第一加强组合物包含血清型35的重组腺病毒载体 （Ad35），第二增强组合物包含Ad26的重组腺病毒，或其中第一促进组合物包含Ad26的重组腺病毒载体，第二加强组合物包含Ad35的重组腺病毒。
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