公开(公告)号：US20090156465A1

公开(公告)日：2009-06-18

申请号：US12159562

申请日：2006-12-12

申请人： Jitendra A. Sattigeri ,  Shahadat Ahmed ,  Murugaiah M.S. Andappan ,  Sachin Sethi ,  Lalima Sharma ,  Chanchal Kumar Pal ,  Sachin Ramesh Kandalkar ,  Dipak C. Mahajan ,  Kaushal Kishore ,  Sumati Bhatia ,  Anil G. Gadhave ,  Vinay S. Bansal ,  Joseph Alexanand Davis

发明人： Jitendra A. Sattigeri ,  Shahadat Ahmed ,  Murugaiah M.S. Andappan ,  Sachin Sethi ,  Lalima Sharma ,  Chanchal Kumar Pal ,  Sachin Ramesh Kandalkar ,  Dipak C. Mahajan ,  Kaushal Kishore ,  Sumati Bhatia ,  Anil G. Gadhave ,  Vinay S. Bansal ,  Joseph Alexanand Davis

IPC分类号： A61K38/28 ,  C07D413/02 ,  A61K31/5377 ,  C07D241/36 ,  A61K31/4995 ,  A61K31/702 ,  A61K31/397 ,  A61P3/00 ,  A61P3/10 ,  A61P37/00 ,  A61P35/00 ,  A61P1/00 ,  A61P15/08

CPC分类号： C07D409/12 ,  C07C237/20 ,  C07C2603/74 ,  C07D209/44 ,  C07D209/52 ,  C07D211/58 ,  C07D401/12 ,  C07D405/12 ,  C07D487/08

摘要： The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.

摘要翻译： 本发明涉及作为二肽基肽酶-IV抑制剂的β-氨基酸衍生物及其合成方法。 本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。 这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化，类风湿性关节炎所表现的病症; 病毒，癌症和胃肠道疾病。 本发明的化合物也可用于治疗由于多囊卵巢综合征引起的不育症。