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公开(公告)号：US20120157468A1
公开(公告)日：2012-06-21
申请号：US13387051
申请日：2010-07-22
IPC分类号： A61K31/519 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04 , A61K31/517
摘要： The present invention relates to novel crystalline, water-soluble salts of a plk inhibitor. Such crystal salts are for example L-tartrate, succinate, phosphate, mesylate, maleate, L-malate, hydrochloride, fumarate (half mole of counterion), fumarate, citrate (half mole of counterion), benzenesulfonate and L-aspartate (half mole of counterion). New crystal forms of the base as well as solvates and hydrates of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.
摘要翻译： 本发明涉及一种plk抑制剂的新型结晶水溶性盐。 这种晶体盐是例如L-酒石酸盐，琥珀酸盐，磷酸盐，甲磺酸盐，马来酸盐，L-苹果酸盐，盐酸盐，富马酸盐（半抗衡离子），富马酸盐，柠檬酸盐（半摩尔抗衡离子），苯磺酸盐和L-天冬氨酸盐 的抵消）。 本申请中还要求保护和描述基础的新晶形以及这种新盐形式的溶剂合物和水合物，其制备方法，其在治疗中的用途和含有它们的药物组合物。
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公开(公告)号：US20070010517A1
公开(公告)日：2007-01-11
申请号：US10588808
申请日：2003-06-04
IPC分类号： C07D265/32 , A61K31/5375
CPC分类号： A61K31/5375 , C07D265/30
摘要： The present invention relates to novel crystalline, water-soluble salts of the 2S,3S enantiomer of reboxetine, which are the fumarate and succinate salts thereof, to a process for their preparation, to their utility in therapy and to pharmaceutical corn-positions containing them.
摘要翻译： 本发明涉及作为其富马酸盐和琥珀酸盐的瑞波西汀的2S，3S对映体的新型结晶水溶性盐，其制备方法，其在治疗中的应用和含有它们的药物玉米位置 。
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公开(公告)号：US20120041007A1
公开(公告)日：2012-02-16
申请号：US13265918
申请日：2010-04-23
IPC分类号： A61K31/519 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel crystalline form(s) of water-soluble salts and of free base of a cdk inhibitor. Such crystal salts are for example fumarate, L-malate, maleate, succinate, adipate, malonate, glycolate, phosphate, mesylate, L-lactate, hydrochloride, di-hydrochloride, tri-hydrochloride. Hydrates and polymorphs of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.
摘要翻译： 本发明涉及新型的水溶性盐和cdk抑制剂游离碱的结晶形式。 这种结晶盐例如是富马酸盐，L-苹果酸盐，马来酸盐，琥珀酸盐，己二酸盐，丙二酸盐，乙醇酸盐，磷酸盐，甲磺酸盐，L-乳酸盐，盐酸盐，二盐酸盐，三盐酸盐。 这种新盐形式的水合物和多晶型物，其制备方法，其在治疗中的用途和含有它们的药物组合物在本申请中也被要求保护和描述。
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公开(公告)号：US20090291953A1
公开(公告)日：2009-11-26
申请号：US12469780
申请日：2009-05-21
IPC分类号： A61K31/5377 , C07D413/02
CPC分类号： A61K31/5375 , C07D265/30
摘要： The present invention relates to novel crystalline, water-soluable salts of the 2S,3S enantiomer of reboxetine, which are the fumarate and succinate salts thereof, to a process for their preparation, to their utility in therapy and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及作为其制备方法，其在治疗中的用途和含有它们的药物组合物的瑞波西汀的2S，3S对映异构体的富马酸和琥珀酸盐的新型结晶水溶性盐。
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公开(公告)号：US08648078B2
公开(公告)日：2014-02-11
申请号：US13387051
申请日：2010-07-22
IPC分类号： A61K31/497 , C07D491/00
CPC分类号： C07D487/04 , A61K31/517
摘要： The present invention relates to novel crystalline, water-soluble salts of a plk inhibitor. Such crystal salts are for example L-tartrate, succinate, phosphate, mesylate, maleate, L-malate, hydrochloride, fumarate (half mole of counterion), fumarate, citrate (half mole of counterion), benzenesulfonate and L-aspartate (half mole of counterion). New crystal forms of the base as well as solvates and hydrates of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.
摘要翻译： 本发明涉及一种plk抑制剂的新型结晶水溶性盐。 这种晶体盐是例如L-酒石酸盐，琥珀酸盐，磷酸盐，甲磺酸盐，马来酸盐，L-苹果酸盐，盐酸盐，富马酸盐（半抗衡离子），富马酸盐，柠檬酸盐（半摩尔抗衡离子），苯磺酸盐和L-天冬氨酸盐 的抵消）。 本申请中还要求保护和描述基础的新晶形以及这种新盐形式的溶剂合物和水合物，其制备方法，其在治疗中的用途和含有它们的药物组合物。
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公开(公告)号：US08586598B2
公开(公告)日：2013-11-19
申请号：US13265918
申请日：2010-04-23
IPC分类号： A61K31/505 , C07D491/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel crystalline form(s) of water-soluble salts and of free base of a cdk inhibitor. Such crystal salts are for example fumarate, L-malate, maleate, succinate, adipate, malonate, glycolate, phosphate, mesylate, L-lactate, hydrochloride, di-hydrochloride, tri-hydrochloride. Hydrates and polymorphs of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.
摘要翻译： 本发明涉及新型的水溶性盐和cdk抑制剂游离碱的结晶形式。 这种结晶盐例如是富马酸盐，L-苹果酸盐，马来酸盐，琥珀酸盐，己二酸盐，丙二酸盐，乙醇酸盐，磷酸盐，甲磺酸盐，L-乳酸盐，盐酸盐，二盐酸盐，三盐酸盐。 这种新盐形式的水合物和多晶型物，其制备方法，其在治疗中的用途和含有它们的药物组合物在本申请中也被要求保护和描述。
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