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公开(公告)号：US20070010517A1
公开(公告)日：2007-01-11
申请号：US10588808
申请日：2003-06-04
IPC分类号： C07D265/32 , A61K31/5375
CPC分类号： A61K31/5375 , C07D265/30
摘要： The present invention relates to novel crystalline, water-soluble salts of the 2S,3S enantiomer of reboxetine, which are the fumarate and succinate salts thereof, to a process for their preparation, to their utility in therapy and to pharmaceutical corn-positions containing them.
摘要翻译： 本发明涉及作为其富马酸盐和琥珀酸盐的瑞波西汀的2S，3S对映体的新型结晶水溶性盐，其制备方法，其在治疗中的应用和含有它们的药物玉米位置 。
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公开(公告)号：US20100106134A1
公开(公告)日：2010-04-29
申请号：US12579778
申请日：2009-10-15
申请人： Claude Jolly , Alessandro Martini
发明人： Claude Jolly , Alessandro Martini
CPC分类号： A61M31/002 , A61F11/00 , A61M31/00
摘要： A drug delivery device for the inner ear is described. A drug delivery member for the inner ear without any stimulation electrodes has an intra-cochlear portion that penetrates into the inner ear of the patient and contains a drug eluting polymer material having at least one therapeutic drug which is released over time in a therapeutically effective amount into fluid in the inner ear of the patient.
摘要翻译： 描述了用于内耳的药物递送装置。 用于没有任何刺激电极的内耳的药物递送部件具有渗透到患者的内耳中的耳蜗内部分，并且含有具有至少一种治疗药物的药物洗脱聚合物材料，其以治疗有效量随时间释放 进入患者内耳中的流体。
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公开(公告)号：US06495534B2
公开(公告)日：2002-12-17
申请号：US09571395
申请日：2000-05-15
IPC分类号： A61K3156
CPC分类号： A61K47/183 , A61K9/0019 , A61K9/10
摘要： A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of L-Methionine. Preferably, the biologically active compound is a steroidal compound, for instance exemestane, medroxyprogesterone acetate and estradiol cypionate or a combination of medroxyprogesterone acetate and estradiol cypionate.
摘要翻译： 用于肠胃外给药的药物水性悬浮液制剂，其具有基本上稳定的pH，包含生物活性化合物和控制L-甲硫氨酸有效浓度的pH。优选地，生物活性化合物是类固醇化合物，例如依西美坦，乙酸甲羟孕酮和丙酸雌二醇或 乙酸甲羟孕酮和丙酸雌二醇的组合。
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公开(公告)号：US20120273105A1
公开(公告)日：2012-11-01
申请号：US13497329
申请日：2010-09-21
IPC分类号： B60C11/117 , B60C11/11
CPC分类号： B60C11/0311 , B60C11/0309 , B60C11/032 , B60C11/11 , B60C11/1281 , B60C11/13 , B60C2011/133
摘要： A winter tyre with improved traction on snow surfaces; the tyre has a tread with a raised pattern defined by a number of longitudinal and transverse grooves which form at least one longitudinal row of blocks projecting radially from a base surface of the tread. Each block has two longitudinal lateral surfaces bounding two corresponding longitudinal grooves, and two transverse lateral surfaces bounding two corresponding transverse grooves. At least one of the blocks has lateral channels, each of which is formed on the lateral surface of a corresponding block, extends from the base surface of the tread to a top surface of the block, and is designed to impede radial spin-out of snow trapped inside the lateral channel.
摘要翻译： 冬季轮胎，具有改善的雪面牵引力; 轮胎具有由多个纵向和横向槽限定的凸起图案的胎面，其形成从胎面的基面径向伸出的至少一个纵向排的块。 每个块具有两个纵向侧表面，其两个对应的纵向槽和两个横向横向表面，两个横向横向表面限定两个对应的横向槽。 至少一个块具有横向通道，每个通道形成在相应块的侧表面上，从胎面的基面延伸到块的顶表面，并被设计成阻止径向旋出 侧面通道内积雪。
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公开(公告)号：US20110224629A1
公开(公告)日：2011-09-15
申请号：US13105220
申请日：2011-05-11
申请人： Claude Jolly , Alessandro Martini
发明人： Claude Jolly , Alessandro Martini
CPC分类号： A61M31/002 , A61F11/00 , A61M31/00
摘要： A drug delivery device for the inner ear is described. A drug delivery member for the inner ear without any stimulation electrodes has an intra-cochlear portion that penetrates into the inner ear of the patient and contains a drug eluting polymer material having at least one therapeutic drug which is released over time in a therapeutically effective amount into fluid in the inner ear of the patient. An extra-cochlear portion of the drug delivery member resides in the middle ear of a patient and completely occludes where the intra-cochlear portion penetrates into the inner ear. An anchor rod is within the intra-cochlear portion of the drug delivery member and adapted to extend out into the middle ear, ending in a retrieval knob for pulling the drug delivery member out of the cochlea.
摘要翻译： 描述了用于内耳的药物递送装置。 用于没有任何刺激电极的内耳的药物递送部件具有渗透到患者的内耳中的耳蜗内部分，并且含有具有至少一种治疗药物的药物洗脱聚合物材料，其以治疗有效量随时间释放 进入患者内耳中的流体。 药物递送部件的非耳蜗部分位于患者的中耳中，并且在耳蜗内部渗入内耳内完全闭塞。 锚杆在药物递送构件的耳蜗内部分内并且适于延伸到中耳中，终止于用于将药物递送构件拉出耳蜗的取出旋钮。
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公开(公告)号：US06673805B2
公开(公告)日：2004-01-06
申请号：US10225607
申请日：2002-08-22
申请人： Sara Lauria , Alessandro Martini , Cristina Ciocca
发明人： Sara Lauria , Alessandro Martini , Cristina Ciocca
IPC分类号： A61K3144
CPC分类号： A61K31/555 , A61K9/0019 , A61K31/519 , A61K47/12
摘要： The present invention relates to novel stable solution formulations comprising oxaliplatin alone or in combination with irinotecan (CPT-11), an effective stabilizing amount of lactic acid and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method for manufacturing such formulations ready for administration and their use in the antitumor therapy are also within the scope of the invention.
摘要翻译： 本发明涉及包含奥沙利铂单独或与伊立替康（CPT-11），有效稳定量的乳酸和/或其药学上可接受的盐和药学上可接受的载体组合的新型稳定溶液制剂。 制备这种准备用于给药的制剂及其在抗肿瘤治疗中的用途的方法也在本发明的范围内。
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7.发明授权Formulations for parenteral use of estramustine phosphate and sulfoalkyl ether cyclodextrins 失效胃肠外使用雌激素磷酸盐和磺烷基醚环糊精的制剂公开(公告)号：US06730664B1
公开(公告)日：2004-05-04
申请号：US10070416
申请日：2002-03-15
IPC分类号： A61K31724
CPC分类号： A61K9/0019 , A61K31/661 , A61K45/06 , A61K47/40 , A61K2300/00
摘要： A pharmaceutical formulation which comprises a parenterally acceptable carrier or diluent, estramustine phosphate and a sulfoalkyl ether cyclodextrin. The formulation can be administered according to a combined chemotherapy regimen in association with one or more chemotherapeutic agents. The formulation also enables estramustin phosphate to be administered with no side effects at the site of injection.
摘要翻译： 一种药物制剂，其包含肠胃外可接受的载体或稀释剂，雌莫司汀磷酸盐和磺基烷基醚环糊精。 该制剂可以根据与一种或多种化学治疗剂联合的联合化疗方案施用。 该制剂还能够在注射部位施用没有副作用的磷酸雌莫司汀。
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公开(公告)号：US06569452B1
公开(公告)日：2003-05-27
申请号：US09857188
申请日：2001-06-20
IPC分类号： A61K948
CPC分类号： A61K9/4866 , A61K9/4816 , A61K31/4745 , Y10S514/962
摘要： An oral pharmaceutical formulation, which comprises, in a hydroxypropylmethylcellulose capsule, a camptothecin analogue dispersed or solubilized in a semi-solid matrix of a polyethyleneglycol with a molecular weight ranging from 400 to 20000.
摘要翻译： 一种口服药物制剂，其在羟丙基甲基纤维素胶囊中包含分散或溶解在分子量为400至20000的聚乙二醇的半固体基质中的喜树碱类似物。
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公开(公告)号：US06476068B1
公开(公告)日：2002-11-05
申请号：US10010122
申请日：2001-12-06
申请人： Sara Lauria , Alessandro Martini , Cristina Ciocca
发明人： Sara Lauria , Alessandro Martini , Cristina Ciocca
IPC分类号： A61K3128
CPC分类号： A61K31/555 , A61K9/0019 , A61K31/519 , A61K47/12
摘要： The present invention relates to novel stable solution formulations comprising oxaliplatin, an effective stabilizing amount of lactic acid and/or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method for manufacturing such formulations ready for administration and their use in the antitumor therapy are also within the scope of the invention.
摘要翻译： 本发明涉及包含奥沙利铂，有效稳定量的乳酸和/或其药学上可接受的盐和药学上可接受的载体的新型稳定溶液制剂。 制备这种准备用于给药的制剂及其在抗肿瘤治疗中的用途的方法也在本发明的范围内。
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公开(公告)号：US5126333A
公开(公告)日：1992-06-30
申请号：US561577
申请日：1990-08-02
CPC分类号： B82Y5/00 , A61K47/40 , A61K47/48969
摘要： A pharmaceutical composition comprising a drug and a dehydrated cyclodextrin having improved dissolution properties, and the process for the preparation thereof.
摘要翻译： 包含具有改善的溶解性质的药物和脱水环糊精的药物组合物及其制备方法。
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