公开(公告)号：US20130066195A1

公开(公告)日：2013-03-14

申请号：US13604111

申请日：2012-09-05

申请人： D. Laksen SIRIMANNE ,  Natalie V. FAWZI ,  Douglas S. SUTTON ,  Gail S. LEBOVIC ,  Stanley R. CONSTON ,  Peter M. WISLON ,  Anne B. MORRISSEY ,  Mary Elizabeth BUSH

发明人： D. Laksen SIRIMANNE ,  Natalie V. FAWZI ,  Douglas S. SUTTON ,  Gail S. LEBOVIC ,  Stanley R. CONSTON ,  Peter M. WISLON ,  Anne B. MORRISSEY ,  Mary Elizabeth BUSH

IPC分类号： A61B6/12 ,  A61B8/00

CPC分类号： A61B8/481 ,  A61B90/39 ,  A61B2090/3908 ,  A61B2090/3987 ,  A61K49/006 ,  A61K49/222

摘要： A subcutaneous cavity marking device percutaneously implantable in breast tissue during a biopsy procedure. The marking device including at least two implantable bodies, one made from a first material and another made from a second material wherein the first and second materials are different materials and the at least two implantable bodies are adapted to be inserted into a subcutaneous cavity created by removal of tissue. The at least two implantable bodies are detectable via non-invasive techniques as tissue cavity markers and at least one of the at least two detectable bodies is an electronic chip connected to the other of the at least two implantable bodies.

摘要翻译： 皮下腔标记装置可在活组织检查过程中经皮植入乳腺组织。 所述标记装置包括至少两个可植入体，一个由第一材料制成，另一个由第二材料制成，其中所述第一和第二材料是不同的材料，并且所述至少两个可植入体适于插入由 去除组织。 所述至少两个可植入体可通过非侵入性技术检测为组织腔标记，并且所述至少两个可检测体中的至少一个是连接至所述至少两个可植入体中的另一个的电子芯片。

公开(公告)号：US09669113B1

公开(公告)日：2017-06-06

申请号：US09869282

申请日：1999-12-23

申请人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

发明人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

IPC分类号： A61B6/00 ,  A61K49/00 ,  A61B90/00 ,  A61B17/00

CPC分类号： A61K49/006 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00539 ,  A61B2017/00898 ,  A61B2090/3912 ,  A61B2090/3925 ,  A61B2090/3962 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995 ,  A61K49/0409 ,  A61K49/222

摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

公开(公告)号：US09492570B2

公开(公告)日：2016-11-15

申请号：US12777710

申请日：2010-05-11

申请人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

发明人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

IPC分类号： A61B6/00 ,  A61K49/00 ,  A61B17/00

CPC分类号： A61K49/006 ,  A61B90/39 ,  A61B2017/00539 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995

摘要： Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

摘要翻译： 公开了腔和前哨淋巴结标记装置，标记递送装置和方法。 更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。 公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。 组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。 该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。 还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置， 对患者的至少创伤和毒性。 组合物和方法可用于标记活检腔，以及标记前哨淋巴结。 标记方法还可以将所描述的特征与标记装置和递送装置组合。

公开(公告)号：US20100234726A1

公开(公告)日：2010-09-16

申请号：US12777710

申请日：2010-05-11

申请人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

发明人： D. Laksen Sirimanne ,  Natalie V. Fawzi ,  Douglas S. Sutton ,  Gail S. Lebovic ,  Stanley R. Conston ,  Peter M. Wilson ,  Anne B. Morrissey ,  Mary Elizabeth Bush

IPC分类号： A61B5/05

CPC分类号： A61K49/006 ,  A61B90/39 ,  A61B2017/00539 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61B2090/3987 ,  A61B2090/3995

摘要： Cavity and sentinel lymph node marking 412 devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

摘要翻译： 公开了腔和前哨淋巴结标记412装置，标记递送装置和方法。 更具体地说，在插入体中时，腔标记装置和方法使得能够通过放射照相，乳房X线照相术，回声或其它非侵入性成像技术确定腔的中心，取向和周边。 公开了用于在哺乳动物体内定位前哨淋巴结的组合物和方法，以确定癌细胞是否已扩散到其上。 组合物优选是由载体流体和某种类型的造影剂组成的流体组合物; 或者，造影剂本身可以是流体，因此不需要单独的载体流体。 该组合物能够（1）沉积在病变中或周围，并且迁移到相关的前哨淋巴结中并累积在相关的前哨淋巴结中，以及（2）通过任何数量的无创技术的远程检测。 还公开了一种用于通过以下步骤远程检测前哨节点的位置的方法：（1）在病变中或周围沉积可远程检测的流体，以便迁移到相关联的前哨节点并累积在相关联的哨兵节点中;以及（2）远程检测该节点的位置， 对患者的至少创伤和毒性。 组合物和方法可用于标记活检腔，以及标记前哨淋巴结。 标记方法还可以将所描述的特征与标记装置和递送装置组合。