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1.发明授权Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效环状尿素衍生物，其制备方法及其作为激酶抑制剂的药物用途公开(公告)号：US07759379B2
公开(公告)日：2010-07-20
申请号：US11627518
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard
IPC分类号： C07D239/02 , A61K31/505 , A61P43/00
CPC分类号： C07D403/04
摘要： The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R1，R2，L1，X，R3，A，R4，R4'，R4“，R4”'，R5，Y和L2如本文所定义， 作为蛋白激酶抑制剂的用途，以及治疗包括其施用的疾病的方法。
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2.发明申请Heterocycle-Substituted Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors 审中-公开杂环取代的环状尿素衍生物，其制备方法及其药物用途作为激酶抑制剂公开(公告)号：US20070259891A1
公开(公告)日：2007-11-08
申请号：US11627505
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Jean-Luc Malleron
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Jean-Luc Malleron
IPC分类号： A61K31/4439 , A61K31/4709 , A61K31/506 , A61P11/06 , A61P17/00 , A61P21/00 , A61P3/00 , A61P35/00 , A61P37/08 , A61P9/00 , C07D215/00 , C07D401/02 , C07D401/14
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The disclosure relates to compounds of formula (I): wherein Y, Y1, Yo, R1, R2, R2′, p, R3, R3′, A, B and Y2 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
摘要翻译： 本公开涉及式（I）的化合物：其中Y，Y 1，Y 1，R 1，R 2，R 2，p ，R 3，R 3'，A，B和Y 2具有本说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白质的用途 激酶抑制剂。
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3.发明申请Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors 失效循环脲衍生物，其制备方法及其药物用途作为激酶抑制剂公开(公告)号：US20080004300A1
公开(公告)日：2008-01-03
申请号：US11627518
申请日：2007-01-26
申请人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Herve Bouchard
发明人： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Herve Bouchard
IPC分类号： A61K31/505 , A61P43/00 , C07D239/02
CPC分类号： C07D403/04
摘要： The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R 1，R 2，L 1，X，R 3，A，R 4，R 4， R 4，R 4，R 5，Y和L 2如本文所定义，其盐和前药，用作蛋白激酶 抑制剂，以及治疗疾病的方法，包括给药。
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