利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

29 条记录 (耗时 0.047 秒)

    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
    8.
    发明授权
    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 有权
    氨基吲唑衍生物作为药物和药物组合物，包括它们

    公开(公告)号：US07166629B2

    公开(公告)日：2007-01-23

    申请号：US10654703

    申请日：2003-09-04

    申请人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    发明人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney

    IPC分类号： A61K31/416 ,  C07D231/56

    CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

    摘要： The present invention relates to novel derivatives of general formula (I) in which R3 is a (1–6C)alkyl, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, aryl or heteroaryl fused to a (1–10C)cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5 and R6 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1–6C)alkyl, (1–6C)alkoxy, aryl, aryl(1–6C)alkyl, heteroaryl, heteroaryl(1–6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl.

    摘要翻译： 本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或杂芳基 （1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（-NH）NR1 激进; R 5和R 6彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，COOH，C（O）OR 8， -OC（O）R8，NR8R9，NHC（O）R8，C（O）NR8R9，NHC（S）R8，C（S）NR8R9，SR8，S（O） R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2 -O （1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，链烯基，炔基，金刚烷基 或多环烷基。

    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them
    10.
    发明授权
    Aminoindazole derivatives as medicaments and pharmaceutical compositions including them 失效
    氨基吲唑衍生物作为药物和药物组合物，包括它们

    公开(公告)号：US07407981B2

    公开(公告)日：2008-08-05

    申请号：US11683452

    申请日：2007-03-08

    申请人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney ,  Gilles Tiraboschi

    发明人： Dominique Lesuisse ,  Gilles Dutruc-Rosset ,  Franck Halley ,  Didier Babin ,  Thomas Rooney ,  Gilles Tiraboschi

    IPC分类号： A61K31/415 ,  C07D231/00

    CPC分类号： C07D231/56 ,  A61K31/416 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12

    摘要： The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl, heterocycle, heterocycloalkyl, cycloalkyl, adamantyl, polycycloalkyl, alkenyl, alkynyl, CONR1R2, COOR1, SO2R1, C(═NH)R1 or C(═NH)NR1 radical; R5, R6 and R7 are, independently of one another, chosen from the following radicals: halogen, CN, NO2, NH2, OH, OR8, COOH, C(O)OR8, —O—C(O)R8, NR8R9, NHC(O)R8, C(O)NR8R9, NHC(S)R8, C(S)NR8R9, SR8, S(O)R8, SO2R8, NHSO2R8, SO2NR8R9, —O—SO2R8, —SO2—O—R8, trifluoromethyl, trifluoromethoxy, (1-6C)alkyl, (1-6C)alkoxy, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, heterocycle, cycloalkyl, alkenyl, alkynyl, adamantyl or polycycloalkyl, to treat a disease selected from the group consisting of: neurodegenerative diseases, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovaries syndrome, syndrome X, immunodeficiency and cancer.

    摘要翻译： 本发明涉及通式（I）的新型衍生物，其中R3是（1-6C）烷基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，芳基或 与（1-10C）环烷基，杂环，杂环烷基，环烷基，金刚烷基，多环烷基，烯基，炔基，CONR1R2，COOR1，SO2R1，C（-NH）R1或C（ - NH）NR1基; R 5，R 6和R 7彼此独立地选自以下基团：卤素，CN，NO 2，NH 2，OH，OR 8，COOH，C（ O）OR 8，-OC（O）R 8，NR 8 R 9，NHC（O）R 8，C（O）NR 8 R 9，NHC（S）R 8，C（S）NR 8 R 9，SR 8，S（O）R 8，SO 2 R 8，NHSO 2 R 8，SO 2 NR 8 R 9，-O-SO 2 R 8，-SO 2， （1-6C）烷氧基，芳基，芳基（1-6C）烷基，杂芳基，杂芳基（1-6C）烷基，杂环，环烷基，烯基 ，炔基，金刚烷基或多环烷基，以治疗选自以下的疾病：神经变性疾病，中风，颅脑和脊髓创伤和周围神经病变，肥胖症，代谢疾病，II型糖尿病，原发性高血压，动脉粥样硬化心血管疾病，多囊卵巢综合征 ，综合征X，免疫缺陷和癌症。