公开(公告)号：US07867985B2

公开(公告)日：2011-01-11

申请号：US10853611

申请日：2004-05-25

申请人： Julie-Anne Mason Burdick ,  Martine Laberge ,  Gary Lickfield

发明人： Julie-Anne Mason Burdick ,  Martine Laberge ,  Gary Lickfield

IPC分类号： A61K31/721 ,  C08B37/02

CPC分类号： A61L27/50 ,  A61K31/683 ,  A61K31/721 ,  A61L27/00 ,  A61L27/28 ,  A61L2400/10 ,  A61L2430/24 ,  C08L5/02

摘要： Fluid compositions and methods for lubrication of mammalian joints are disclosed, including both natural and artificial fluids. Synovial fluid acts to lubricate the bearing surfaces of bones and bone-like structures which are held in frictional contact within biological joints. Such fluids may be used to treat arthritic, injured, and diseased joints. Synovial fluid containing a dextran-based hydrogel with lipids provides enhanced rheological and tribological properties of such a fluid. Phospholipids are particularly useful in dextran-based compositions for synovial fluid. One phospholipid that can be used advantageously in synovial fluid is dipalmitoyl phosphatidylcholine (DPPC).

摘要翻译： 公开了用于哺乳动物关节润滑的流体组合物和方法，包括天然和人造液体。 滑液用于润滑在生物关节内保持摩擦接触的骨骼和骨骼结构的支撑表面。 这种流体可用于治疗关节炎，受伤和患病的关节。 含有基于葡聚糖的水凝胶与脂质的滑液提供了这种流体的增强的流变学和摩擦学性质。 磷脂在用于滑液的基于葡聚糖的组合物中特别有用。 可在滑液中有利使用的一种磷脂是二棕榈酰磷脂酰胆碱（DPPC）。

公开(公告)号：US20050054043A1

公开(公告)日：2005-03-10

申请号：US10887711

申请日：2004-07-08

申请人： Walter Funk ,  Ross MacGillivray ,  Anne Mason ,  Robert Woodworth

发明人： Walter Funk ,  Ross MacGillivray ,  Anne Mason ,  Robert Woodworth

IPC分类号： A61K38/00 ,  C07K14/79 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/705 ,  C07K14/78

CPC分类号： C07K14/79 ,  A61K38/00

摘要： Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functional form by stable eukaryotic cell lines such as baby hamster kidney cells transformed with an expression vector encoding the recombinant molecule. The recombinant transferrins can be used in metal chelation therapy to bind and clear excess toxic metals in patients suffering from metal overloads or as tissue culture medium supplements or replacements.

摘要翻译： 描述了具有改变的金属结合或其它性质的重组转铁蛋白，非糖基化重组转铁蛋白，转铁蛋白半分子和突变体转运蛋白。 重组转铁蛋白分子以稳定的真核细胞系如用编码重组分子的表达载体转化的幼仓鼠肾细胞以功能形式表达。 重组转移蛋白可用于金属螯合治疗，以结合和清除患有金属超负荷或组织培养基补充剂或替代物的患者中的过量有毒金属。

公开(公告)号：US06800298B1

公开(公告)日：2004-10-05

申请号：US09569009

申请日：2000-05-11

申请人： Julie-Anne Mason Burdick ,  Martine Laberge ,  Gary Lickfield

发明人： Julie-Anne Mason Burdick ,  Martine Laberge ,  Gary Lickfield

IPC分类号： A61K916

CPC分类号： A61L27/50 ,  A61K31/683 ,  A61K31/721 ,  A61L27/00 ,  A61L27/28 ,  A61L2400/10 ,  A61L2430/24 ,  C08L5/02

摘要： Fluid compositions and methods for lubrication of mammalian joints are disclosed, including both natural and artificial fluids. Synovial fluid acts to lubricate the bearing surfaces of bones and bone-like structures which are held in frictional contact within biological joints. Such fluids may be used to treat arthritic, injured, and diseased joints. Synovial fluid containing a dextran-based hydrogel with lipids provides enhanced rheological and tribological properties of such a fluid. Phospholipids are particularly useful in dextran-based compositions for synovial fluid. One phospholipid that can be used advantageously in synovial fluid is dipalmitoyl phosphatidylcholine (DPPC).

摘要翻译： 公开了用于哺乳动物关节润滑的流体组合物和方法，包括天然和人造液体。 滑液用于润滑在生物关节内保持摩擦接触的骨骼和骨骼结构的支撑表面。 这种流体可用于治疗关节炎，受伤和患病的关节。 含有基于葡聚糖的水凝胶与脂质的滑液提供了这种流体的增强的流变学和摩擦学性质。 磷脂在用于滑液的基于葡聚糖的组合物中特别有用。 可在滑液中有利使用的一种磷脂是二棕榈酰磷脂酰胆碱（DPPC）。